Drug-induced liver injury associated with noni (Morinda citrifolia) juice and phenobarbital

Case Reports in Gastroenterology

Volumn 7, Issue 1, 2013, Pages 19-24

  Mrzljak, Anna ^a,d   Kosuta, Iva ^a   Skrtic, Anita ^b,d   Filipec Kanizaj, Tajana ^a,d   Vrhovac, Radovan ^c  

^a University of Zagreb   (Croatia)

^b University Hospital Merkur   (Croatia)

^c KBC Zagreb   (Croatia)

^d UNIVERSITY OF ZAGREB   (Croatia)

Author keywords

Drug induced liver injury; Herb induced liver injury; Noni juice; Phenobarbital

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CORTICOSTEROID; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; GAMMA GLUTAMYLTRANSFERASE; PHENOBARBITAL; MORINDA CITRIFOLIA EXTRACT;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CASE REPORT; DIET SUPPLEMENTATION; EOSINOPHIL; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GENOTYPE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATORY INFILTRATE; INTERNATIONAL NORMALIZED RATIO; INTRAHEPATIC CHOLESTASIS; LIVER BIOPSY; LIVER CELL DAMAGE; LIVER PROTECTION; LONG TERM EXPOSURE; LYMPHOCYTOSIS; MORINDA CITRIFOLIA; PORTAL VEIN; PRIORITY JOURNAL; TOXIC HEPATITIS; TREATMENT DURATION; ANTICONVULSANT THERAPY; LABORATORY TEST; LIVER FUNCTION TEST; LIVER TOXICITY;

EID: 84877995330     PISSN: None     EISSN: 16620631     Source Type: Journal    
DOI: 10.1159/000343651     Document Type: Article

References (31)

1. Ostapowicz G, Fontana RJ, Schiødt FV, Larson A, Davern TJ, Han SH, McCashland TM, Shakil AO, Hay JE, Hynan L, Crippin JS, Blei AT, Samuel G, Reisch J, Lee WM: U.S. Acute Liver Failure Study Group: Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 2002;137:947-954.
2. Watkins PB, Seeff LB: Drug-induced liver injury: summary of a single topic clinical research conference. Hepatology 2006;43:618-631.
3. Pawlus AD, Kinghorn AD: Review of the ethnobotany, chemistry, biological activity and safety of the botanical dietary supplement Morinda citrifolia (noni). J Pharm Pharmacol 2007;59:1587-1609.
4. McClatchey W: From Polynesian healers to health food stores: changing perspectives of Morinda citrifolia (Rubiaceae). Integr Cancer Ther 2002;1:110-120.
5. Wang MY, Su C: Cancer preventive effect of Morinda citrifolia (noni). Ann N Y Acad Sci 2001;952: 161-168.
6. Wang MY, Anderson G, Nowicki D, Jensen J: Hepatic protection by noni fruit juice against CCl(4)-induced chronic liver damage in female SD rats. Plant Foods Hum Nutr 2008;63:141-145.
7. West BJ, Su CX, Jensen CJ: Hepatotoxicity and subchronic toxicity tests of Morinda citrifolia (noni) fruit. J Toxicol Sci 2009;34:581-585.
8. Millonig G, Stadlmann S, Vogel W: Herbal hepatotoxicity: acute hepatitis caused by a Noni preparation (Morinda citrifolia). Eur J Gastroenterol Hepatol 2005;17:445-447.
9. Yuce B, Gulberg V, Diebold J, Gerbes AL: Hepatitis induced by Noni juice from Morinda citrifolia: a rare cause of hepatotoxicity or the tip of the iceberg? Digestion 2006;73:167-170.
10. Stadlbauer V, Fickert P, Lackner C, Schmerlaib J, Krisper P, Trauner M, Stauber RE: Hepatotoxicity of NONI juice: report of two cases. World J Gastroenterol 2005;11:4758-4760.
11. López-Cepero Andrada JM, Lerma Castilla S, Fernández Olvera MD, Amaya Vidal A: Hepatotoxicity caused by a Noni (Morinda citrifolia) preparation. Rev Esp Enferm Dig 2007;99:179-181.
12. Stadlbauer V, Weiss S, Payer F, Stauber RE: Herbal does not all mean innocuous: the sixth case of hepatotoxicity associated with Morinda citrifolia (noni). Am J Gastroenterol 2008;103:2406-2407.
13. Yu EL, Sivagnanam M, Ellis L, Huang JS: Acute hepatotoxicity after ingestion of Morinda citrifolia (Noni Berry) juice in a 14-year-old boy. J Pediatr Gastroenterol Nutr 2011;52:222-224.
14. Aithal GP, Watkins PB, Andrade RJ, Larrey D, Molokhia M, Takikawa H, Hunt CM, Wilke RA, Avigan M, Kaplowitz N, Bjornsson E, Daly AK: Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther 2011;89:806-815.
15. Sgro C, Clinard F, Ouazir K, Chanay H, Allard C, Guilleminet C, Lenoir C, Lemoine A, Hillon P: Incidence of drug-induced hepatic injuries: a French population-based study. Hepatology 2002;36:451-455.
16. Vuppalanchi R, Liangpunsakul S, Chalasani N: Etiology of new-onset jaundice: how often is it caused by idiosyncratic drug-induced liver injury in the United States? Am J Gastroenterol 2007;102:558-562.
17. Carey EJ, Vargas HE, Douglas DD, Balan V, Byrne TJ, Harrison ME, Rakela J: Inpatient admissions for drug-induced liver injury: results from a single center. Dig Dis Sci 2008;53:1977-1982.
18. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, Janecek E, Domecq C, Greenblatt DJ: A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30: 239-245.
19. Bégaud B, Evreux JC, Jouglard J, Lagier G: Imputation of the unexpected or toxic effects of drugs. Actualization of the method used in France. Therapie 1985;40:111-118.
20. Danan G, Benichou C: Causality assessment of adverse reactions to drugs-I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol 1993;46:1323-1330.
21. Benichou C, Danan G, Flahault A: Causality assessment of adverse reactions to drugs-II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol 1993;46:1331-1336.
22. Maria VA, Victorino RM: Development and validation of a clinical scale for the diagnosis of drug-induced hepatitis. Hepatology 1997;26:664-669.
23. García-Cortés M, Stephens C, Fernández- Castañer A, Lucena MI, Andrade RJ: Causality assessment methods in drug induced liver injury: strengths and weaknesses. J Hepatol 2011;55:683-691.
24. Navarro VJ, Senior JR: Drug-related hepatotoxicity. N Engl J Med 2006;354:731-739.
25. Bissell DM, Gores GJ, Laskin DL, Hoofnagle JH: Drug-induced liver injury: mechanisms and test systems. Hepatology 2001;33:1009-1013.
26. Liu ZX, Kaplowitz N: Immune-mediated drug-induced liver disease. Clin Liver Dis 2002;6:755-774.
27. Björnsson E: Review article: drug-induced liver injury in clinical practice. Aliment Pharmacol Ther 2010;32:3-13.
28. Valente G, Sanges M, Campione S, Bellevicine C, De Franchis G, Sollazzo R, Mattera D, Cimino L, Vecchione R, D'Arienzo A: Herbal hepatotoxicity: a case of difficult interpretation. Eur Rev Med Pharmacol Sci 2010;14:865-870.
29. Potterat O, Hamburger M: Morinda citrifolia (Noni) fruit-phytochemistry, pharmacology, safety. Planta Med 2007;73:191-199.
30. Wang MY, West BJ, Jensen CJ, Nowicki D, Su C, Palu AK, Anderson G: Morinda citrifolia (Noni): a literature review and recent advances in Noni research. Acta Pharmacol Sin 2002;23:1127-1141.
31. Stickel F, Kessebohm K, Weimann R, Seitz HK: Review of liver injury associated with dietary supplements. Liver Int 2011;31:595-605.