메뉴 건너뛰기




Volumn 195, Issue 10, 2013, Pages 2244-2254

A mutant with aberrant extracellular LcrV-YscF interactions fails to form pores and translocate yop effector proteins but retains the ability to trigger yop secretion in response to host cell contact

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; LCRV PROTEIN; MUTANT PROTEIN; TRANSLOCON; UNCLASSIFIED DRUG; YOP EFFECTOR PROTEIN; YSCF PROTEIN;

EID: 84877983552     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.02011-12     Document Type: Article
Times cited : (12)

References (48)
  • 1
    • 43449122166 scopus 로고    scopus 로고
    • The type III secretion system tip complex and translocon
    • Mueller CA, Broz P, Cornelis GR. 2008. The type III secretion system tip complex and translocon. Mol. Microbiol. 68:1085-1095.
    • (2008) Mol. Microbiol. , vol.68 , pp. 1085-1095
    • Mueller, C.A.1    Broz, P.2    Cornelis, G.R.3
  • 2
    • 0034816137 scopus 로고    scopus 로고
    • Plague and other human infections caused by Yersinia species
    • Putzker M, Sauer H, Sobe D. 2001. Plague and other human infections caused by Yersinia species. Clin. Lab. 47:453-466.
    • (2001) Clin. Lab. , vol.47 , pp. 453-466
    • Putzker, M.1    Sauer, H.2    Sobe, D.3
  • 3
    • 33749341240 scopus 로고    scopus 로고
    • Current trends in plague research: from genomics to virulence
    • Huang XZ, Nikolich MP, Lindler LE. 2006. Current trends in plague research: from genomics to virulence. Clin. Med. Res. 4:189-199.
    • (2006) Clin. Med. Res. , vol.4 , pp. 189-199
    • Huang, X.Z.1    Nikolich, M.P.2    Lindler, L.E.3
  • 5
    • 77957145681 scopus 로고    scopus 로고
    • The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection
    • Durand EA, Maldonado-Arocho FJ, Castillo C, Walsh RL, Mecsas J. 2010. The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection. Cell Microbiol. 12: 1064-1082.
    • (2010) Cell Microbiol. , vol.12 , pp. 1064-1082
    • Durand, E.A.1    Maldonado-Arocho, F.J.2    Castillo, C.3    Walsh, R.L.4    Mecsas, J.5
  • 7
    • 70049090384 scopus 로고    scopus 로고
    • Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model
    • doi:10.1371/journal.ppat.1000551
    • Koberle M, Klein-Gunther A, Schutz M, Fritz M, Berchtold S, Tolosa E, Autenrieth IB, Bohn E. 2009. Yersinia enterocolitica targets cells of the innate and adaptive immune system by injection of Yops in a mouse infection model. PLoS Pathog. 5:e1000551. doi:10.1371/journal.ppat.1000551.
    • (2009) PLoS Pathog. , vol.5
    • Koberle, M.1    Klein-Gunther, A.2    Schutz, M.3    Fritz, M.4    Berchtold, S.5    Tolosa, E.6    Autenrieth, I.B.7    Bohn, E.8
  • 8
    • 33750110911 scopus 로고    scopus 로고
    • The type III secretion injectisome
    • Cornelis GR. 2006. The type III secretion injectisome. Nat. Rev. Microbiol. 4:811-825.
    • (2006) Nat. Rev. Microbiol. , vol.4 , pp. 811-825
    • Cornelis, G.R.1
  • 13
    • 53049091586 scopus 로고    scopus 로고
    • Oligomerization of PcrV and LcrV, protective antigens of Pseudomonas aeruginosa and Yersinia pestis
    • Gebus C, Faudry E, Bohn YS, Elsen S, Attree I. 2008. Oligomerization of PcrV and LcrV, protective antigens of Pseudomonas aeruginosa and Yersinia pestis. J. Biol. Chem. 283:23940-23949.
    • (2008) J. Biol. Chem. , vol.283 , pp. 23940-23949
    • Gebus, C.1    Faudry, E.2    Bohn, Y.S.3    Elsen, S.4    Attree, I.5
  • 16
    • 0029031698 scopus 로고
    • + response, and virulence of Yersinia pestis
    • + response, and virulence of Yersinia pestis. J. Bacteriol. 177:2530-2542.
    • (1995) J. Bacteriol. , vol.177 , pp. 2530-2542
    • Skrzypek, E.1    Straley, S.C.2
  • 17
    • 0029908022 scopus 로고    scopus 로고
    • The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity
    • Hakansson S, Schesser K, Persson C, Galyov EE, Rosqvist R, Homble F, Wolf-Watz H. 1996. The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity. EMBO J. 15:5812-5823.
    • (1996) EMBO J. , vol.15 , pp. 5812-5823
    • Hakansson, S.1    Schesser, K.2    Persson, C.3    Galyov, E.E.4    Rosqvist, R.5    Homble, F.6    Wolf-Watz, H.7
  • 19
    • 0029421061 scopus 로고
    • Translocation of the Yersinia YopE and YopH virulence proteins into target cells is mediated by YopB and YopD
    • Rosqvist R, Persson C, Hakansson S, Nordfeldt R, Wolf-Watz H. 1995. Translocation of the Yersinia YopE and YopH virulence proteins into target cells is mediated by YopB and YopD. Contrib. Microbiol. Immunol. 13:230-234.
    • (1995) Contrib. Microbiol. Immunol. , vol.13 , pp. 230-234
    • Rosqvist, R.1    Persson, C.2    Hakansson, S.3    Nordfeldt, R.4    Wolf-Watz, H.5
  • 21
    • 84934438078 scopus 로고    scopus 로고
    • Roles of YopN, LcrG and LcrV in controlling Yops secretion by Yersinia pestis
    • Hamad MA. Nilles ML. 2007. Roles of YopN, LcrG and LcrV in controlling Yops secretion by Yersinia pestis. Adv. Exp. Med. Biol. 603:225-234.
    • (2007) Adv. Exp. Med. Biol. , vol.603 , pp. 225-234
    • Hamad, M.A.1    Nilles, M.L.2
  • 22
    • 84855824363 scopus 로고    scopus 로고
    • Translocators YopB and YopD from Yersinia enterocolitica form a multimeric integral membrane complex in eukaryotic cell membranes
    • Montagner C, Arquint C, Cornelis GR. 2011. Translocators YopB and YopD from Yersinia enterocolitica form a multimeric integral membrane complex in eukaryotic cell membranes. J. Bacteriol. 193:6923-6928.
    • (2011) J. Bacteriol. , vol.193 , pp. 6923-6928
    • Montagner, C.1    Arquint, C.2    Cornelis, G.R.3
  • 23
    • 0242321266 scopus 로고    scopus 로고
    • Genetic analysis of the formation of the Ysc-Yop translocation pore in macrophages by Yersinia enterocolitica: role of LcrV, YscF and YopN
    • Marenne MN, Journet L, Mota LJ, Cornelis GR. 2003. Genetic analysis of the formation of the Ysc-Yop translocation pore in macrophages by Yersinia enterocolitica: role of LcrV, YscF and YopN. Microb. Pathog. 35: 243-258.
    • (2003) Microb. Pathog. , vol.35 , pp. 243-258
    • Marenne, M.N.1    Journet, L.2    Mota, L.J.3    Cornelis, G.R.4
  • 24
    • 0033485823 scopus 로고    scopus 로고
    • Yersinia enterocolitica type III secretion-translocation system: channel formation by secreted Yops
    • Tardy F, Homble F, Neyt C, Wattiez R, Cornelis GR, Ruysschaert JM, Cabiaux V. 1999. Yersinia enterocolitica type III secretion-translocation system: channel formation by secreted Yops. EMBO J. 18:6793-6799.
    • (1999) EMBO J. , vol.18 , pp. 6793-6799
    • Tardy, F.1    Homble, F.2    Neyt, C.3    Wattiez, R.4    Cornelis, G.R.5    Ruysschaert, J.M.6    Cabiaux, V.7
  • 26
    • 0034711266 scopus 로고    scopus 로고
    • LcrV, a substrate for Yersinia enterocolitica type III secretion, is required for toxin targeting into the cytosol of HeLa cells
    • Lee VT, Tam C, Schneewind O. 2000. LcrV, a substrate for Yersinia enterocolitica type III secretion, is required for toxin targeting into the cytosol of HeLa cells. J. Biol. Chem. 275:36869-36875.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36869-36875
    • Lee, V.T.1    Tam, C.2    Schneewind, O.3
  • 27
    • 22244476683 scopus 로고    scopus 로고
    • Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranes
    • Goure J, Broz P, Attree O, Cornelis GR, Attree I. 2005. Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranes. J. Infect. Dis. 192:218-225.
    • (2005) J. Infect. Dis. , vol.192 , pp. 218-225
    • Goure, J.1    Broz, P.2    Attree, O.3    Cornelis, G.R.4    Attree, I.5
  • 28
    • 0035836714 scopus 로고    scopus 로고
    • Polymerization of a single protein of the pathogen Yersinia enterocolitica into needles punctures eukaryotic cells
    • Hoiczyk E, Blobel G. 2001. Polymerization of a single protein of the pathogen Yersinia enterocolitica into needles punctures eukaryotic cells. Proc. Natl. Acad. Sci. U. S. A. 98:4669-4674.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 4669-4674
    • Hoiczyk, E.1    Blobel, G.2
  • 29
    • 33845938871 scopus 로고    scopus 로고
    • Mutations in the Yersinia pseudotuberculosis type III secretion system needle protein, YscF, that specifically abrogate effector translocation into host cells
    • Davis AJ, Mecsas J. 2007. Mutations in the Yersinia pseudotuberculosis type III secretion system needle protein, YscF, that specifically abrogate effector translocation into host cells. J. Bacteriol. 189:83-97.
    • (2007) J. Bacteriol. , vol.189 , pp. 83-97
    • Davis, A.J.1    Mecsas, J.2
  • 30
    • 25144451293 scopus 로고    scopus 로고
    • The Yersinia pestis type III secretion needle plays a role in the regulation of Yop secretion
    • Torruellas J, Jackson MW, Pennock JW, Plano GV. 2005. The Yersinia pestis type III secretion needle plays a role in the regulation of Yop secretion. Mol. Microbiol. 57:1719-1733.
    • (2005) Mol. Microbiol. , vol.57 , pp. 1719-1733
    • Torruellas, J.1    Jackson, M.W.2    Pennock, J.W.3    Plano, G.V.4
  • 31
    • 0022629859 scopus 로고
    • + in Yersinia pestis include structural genes for outer membrane proteins
    • + in Yersinia pestis include structural genes for outer membrane proteins. Infect. Immun. 51:445-454.
    • (1986) Infect. Immun. , vol.51 , pp. 445-454
    • Straley, S.C.1    Bowmer, W.S.2
  • 32
    • 0141557633 scopus 로고    scopus 로고
    • The ability to replicate in macrophages is conserved between Yersinia pestis and Yersinia pseudotuberculosis
    • Pujol C, Bliska JB. 2003. The ability to replicate in macrophages is conserved between Yersinia pestis and Yersinia pseudotuberculosis. Infect. Immun. 71:5892-5899.
    • (2003) Infect. Immun. , vol.71 , pp. 5892-5899
    • Pujol, C.1    Bliska, J.B.2
  • 33
    • 33846029503 scopus 로고    scopus 로고
    • Intranasal inoculation of mice with Yersinia pseudotuberculosis causes a lethal lung infection that is dependent on Yersinia outer proteins and PhoP
    • Fisher ML, Castillo C, Mecsas J. 2007. Intranasal inoculation of mice with Yersinia pseudotuberculosis causes a lethal lung infection that is dependent on Yersinia outer proteins and PhoP. Infect. Immun. 75:429-442.
    • (2007) Infect. Immun. , vol.75 , pp. 429-442
    • Fisher, M.L.1    Castillo, C.2    Mecsas, J.3
  • 34
    • 0043267521 scopus 로고    scopus 로고
    • Requirement of the Yersinia pseudotuberculosis effectors YopH and YopE in colonization and persistence in intestinal and lymph tissues
    • Logsdon LK, Mecsas J. 2003. Requirement of the Yersinia pseudotuberculosis effectors YopH and YopE in colonization and persistence in intestinal and lymph tissues. Infect. Immun. 71:4595-4607.
    • (2003) Infect. Immun. , vol.71 , pp. 4595-4607
    • Logsdon, L.K.1    Mecsas, J.2
  • 35
    • 0026411101 scopus 로고
    • Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector
    • Donnenberg MS, Kaper JB. 1991. Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector. Infect. Immun. 59:4310-4317.
    • (1991) Infect. Immun. , vol.59 , pp. 4310-4317
    • Donnenberg, M.S.1    Kaper, J.B.2
  • 36
    • 0023777735 scopus 로고
    • Tightly regulated tac promoter vectors useful for the expression of unfused and fused proteins in Escherichia coli
    • Amann E, Ochs B, Abel KJ. 1988. Tightly regulated tac promoter vectors useful for the expression of unfused and fused proteins in Escherichia coli. Gene. 69:301-315.
    • (1988) Gene. , vol.69 , pp. 301-315
    • Amann, E.1    Ochs, B.2    Abel, K.J.3
  • 37
    • 77950228938 scopus 로고    scopus 로고
    • A dominant-negative needle mutant blocks type III secretion of early but not late substrates in Yersinia
    • Davis AJ, Diaz DA, Mecsas J. 2010. A dominant-negative needle mutant blocks type III secretion of early but not late substrates in Yersinia. Mol. Microbiol. 76:236-259.
    • (2010) Mol. Microbiol. , vol.76 , pp. 236-259
    • Davis, A.J.1    Diaz, D.A.2    Mecsas, J.3
  • 38
    • 77955410498 scopus 로고    scopus 로고
    • Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis
    • Harmon DE, Davis AJ, Castillo C, Mecsas J. 2010. Identification and characterization of small-molecule inhibitors of Yop translocation in Yersinia pseudotuberculosis. Antimicrob. Agents Chemother. 54:3241-3254.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 3241-3254
    • Harmon, D.E.1    Davis, A.J.2    Castillo, C.3    Mecsas, J.4
  • 39
    • 0033861270 scopus 로고    scopus 로고
    • The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence
    • Black DS, Bliska JB. 2000. The RhoGAP activity of the Yersinia pseudotuberculosis cytotoxin YopE is required for antiphagocytic function and virulence. Mol. Microbiol. 37:515-527.
    • (2000) Mol. Microbiol. , vol.37 , pp. 515-527
    • Black, D.S.1    Bliska, J.B.2
  • 41
    • 0031885218 scopus 로고    scopus 로고
    • The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD
    • Sarker MR, Neyt C, Stainier I, Cornelis GR. 1998. The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and YopD. J. Bacteriol. 180:1207-1214.
    • (1998) J. Bacteriol. , vol.180 , pp. 1207-1214
    • Sarker, M.R.1    Neyt, C.2    Stainier, I.3    Cornelis, G.R.4
  • 42
    • 77955495219 scopus 로고    scopus 로고
    • YopD self-assembly and binding to LcrV facilitate type III secretion activity by Yersinia pseudotuberculosis
    • Costa TR, Edqvist PJ, Broms JE, Ahlund MK, Forsberg A, Francis MS. 2010. YopD self-assembly and binding to LcrV facilitate type III secretion activity by Yersinia pseudotuberculosis. J. Biol. Chem. 285:25269-25284.
    • (2010) J. Biol. Chem. , vol.285 , pp. 25269-25284
    • Costa, T.R.1    Edqvist, P.J.2    Broms, J.E.3    Ahlund, M.K.4    Forsberg, A.5    Francis, M.S.6
  • 44
    • 30044445766 scopus 로고    scopus 로고
    • The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus
    • Kenjale R, Wilson J, Zenk SF, Saurya S, Picking WL, Picking WD, Blocker A. 2005. The needle component of the type III secreton of Shigella regulates the activity of the secretion apparatus. J. Biol. Chem. 280:42929-42937.
    • (2005) J. Biol. Chem. , vol.280 , pp. 42929-42937
    • Kenjale, R.1    Wilson, J.2    Zenk, S.F.3    Saurya, S.4    Picking, W.L.5    Picking, W.D.6    Blocker, A.7
  • 45
    • 78751584742 scopus 로고    scopus 로고
    • In silico comparison of Yersinia pestis and Yersinia pseudotuberculosis transcriptomes reveals a higher expression level of crucial virulence determinants in the plague bacillus
    • Chauvaux S, Dillies MA, Marceau M, Rosso ML, Rousseau S, Moszer I, Simonet M, Carniel E. 2011. In silico comparison of Yersinia pestis and Yersinia pseudotuberculosis transcriptomes reveals a higher expression level of crucial virulence determinants in the plague bacillus. Int. J. Med. Microbiol. 301:105-116.
    • (2011) Int. J. Med. Microbiol. , vol.301 , pp. 105-116
    • Chauvaux, S.1    Dillies, M.A.2    Marceau, M.3    Rosso, M.L.4    Rousseau, S.5    Moszer, I.6    Simonet, M.7    Carniel, E.8
  • 47
    • 77950231693 scopus 로고    scopus 로고
    • The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding
    • Roehrich AD, Martinez-Argudo I, Johnson S, Blocker AJ, Veenendaal AK. 2010. The extreme C terminus of Shigella flexneri IpaB is required for regulation of type III secretion, needle tip composition, and binding. Infect. Immun. 78:1682-1691.
    • (2010) Infect. Immun. , vol.78 , pp. 1682-1691
    • Roehrich, A.D.1    Martinez-Argudo, I.2    Johnson, S.3    Blocker, A.J.4    Veenendaal, A.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.