The vitamin B6 biosynthesis pathway in streptococcus pneumoniae is controlled by pyridoxal 5'-phosphate and the transcription factor PdxR and has an impact on ear infection

Journal of Bacteriology

Volumn 195, Issue 10, 2013, Pages 2187-2196

  Qaidi, Samir El ^a   Yang, Jun ^a   Zhang, Jing Ren ^a,b   Metzger, Dennis W ^a   Bai, Guangchun ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b Tsinghua University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PYRIDOXAL 5 PHOSPHATE; PYRIDOXINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDXR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; BIOSYNTHESIS; CHINCHILLA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EAR INFECTION; FEMALE; GENE EXPRESSION; MIDDLE EAR; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; BACTERIAL PROTEINS; BLOTTING, NORTHERN; BLOTTING, WESTERN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; MICE; MICE, INBRED BALB C; PNEUMOCOCCAL INFECTIONS; PYRIDOXAL PHOSPHATE; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION FACTORS; VITAMIN B 6;

EID: 84877964249     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.00041-13     Document Type: Article

References (40)

1. Eliot AC, Kirsch JF. 2004. Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations. Annu. Rev. Biochem. 73: 383-415.
2. Grogan DW. 1988. Temperature-sensitive murein synthesis in an Escherichia coli pdx mutant and the role of alanine racemase. Arch. Microbiol. 150:363-367.
3. Horrobin DF. 1993. Fatty acid metabolism in health and disease: the role of delta-6-desaturase. Am. J. Clin. Nutr. 57:732S-737S.
4. 6 (pyridoxine) and its derivatives are efficient singlet oxygen quenchers and potential fungal antioxidants. Photochem. Photobiol. 71:129-134.
5. 6 biosynthesis: not that different after all. Biochem. J. 407:1-13.
6. 6 (pyridoxine) and pyridoxal phosphate biosynthesis pathways. J. Mol. Microbiol. Biotechnol. 3:1-20.
7. Mukherjee T, Hanes J, Tews I, Ealick SE, Begley TP. 2011. Pyridoxal phosphate: biosynthesis and catabolism. Biochim. Biophys. Acta 1814: 1585-1596.
8. Lam HM, Winkler ME. 1992. Characterization of the complex pdxH-tyrS operon of Escherichia coli K-12 and pleiotropic phenotypes caused by pdxH insertion mutations. J. Bacteriol. 174:6033-6045.
9. Neuwirth M, Flicker K, Strohmeier M, Tews I, Macheroux P. 2007. Thermodynamic characterization of the protein-protein interaction in the heteromeric Bacillus subtilis pyridoxalphosphate synthase. Biochemistry 46:5131-5139.
10. Strohmeier M, Raschle T, Mazurkiewicz J, Rippe K, Sinning I, Fitzpatrick TB, Tews I. 2006. Structure of a bacterial pyridoxal 5'-phosphate synthase complex. Proc. Natl. Acad. Sci. U. S. A. 103:19284-19289.
11. Wallner S, Neuwirth M, Flicker K, Tews I, Macheroux P. 2009. Dissection of contributions from invariant amino acids to complex formation and catalysis in the heteromeric pyridoxal 5-phosphate synthase complex from Bacillus subtilis. Biochemistry 48:1928-1935.
12. Yang Y, Tsui HC, Man TK, Winkler ME. 1998. Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12. J. Bacteriol. 180:1814-1821.
13. Safo MK, Musayev FN, di Salvo ML, Hunt S, Claude JB, Schirch V. 2006. Crystal structure of pyridoxal kinase from the Escherichia coli pdxK gene: implications for the classification of pyridoxal kinases. J. Bacteriol. 188:4542-4552.
14. di Salvo ML, Safo MK, Musayev FN, Bossa F, Schirch V. 2003. Structure and mechanism of Escherichia coli pyridoxine 5'-phosphate oxidase. Biochim. Biophys. Acta 1647:76-82.
15. Zhao G, Winkler ME. 1995. Kinetic limitation and cellular amount of pyridoxine (pyridoxamine) 5'-phosphate oxidase of Escherichia coli K-12. J. Bacteriol. 177:883-891.
16. 6 is required for full motility and virulence in Helicobacter pylori. mBio 1:e00112. doi:10.1128/mBio.00112-10.
17. 6 biosynthesis is essential for survival and virulence of Mycobacterium tuberculosis. Mol. Microbiol. 78:980-988.
18. Jochmann N, Gotker S, Tauch A. 2011. Positive transcriptional control of the pyridoxal phosphate biosynthesis genes pdxST by the MocR-type regulator PdxR of Corynebacterium glutamicum ATCC 13032. Microbiology 157:77-88.
19. van de Rijn I, Kessler RE. 1980. Growth characteristics of group A streptococci in a new chemically defined medium. Infect. Immun. 27: 444-448.
20. Pozzi G, Masala L, Iannelli F, Manganelli R, Havarstein L, Piccoli L, Simon D, Morrison D. 1996. Competence for genetic transformation in encapsulated strains of Streptococcus pneumoniae: two allelic variants of the peptide pheromone. J. Bacteriol. 178:6087-6090.
21. Chen H, Ma Y, Yang J, O'Brien CJ, Lee SL, Mazurkiewicz JE, Haataja S, Yan JH, Gao GF, Zhang JR. 2008. Genetic requirement for pneumococcal ear infection. PLoS One 3:e2950. doi:10.1371/journal.pone.0002950.
22. Lu L, Ma Y, Zhang JR. 2006. Streptococcus pneumoniae recruits complement factor H through the amino terminus of CbpA. J. Biol. Chem. 281: 15464-15474.
23. Macrina FL, Evans RP, Tobian JA, Hartley DL, Clewell DB, Jones KR. 1983. Novel shuttle plasmid vehicles for Escherichia-Streptococcus transgeneric cloning. Gene 25:145-150.
24. Bai G, Schaak DD, Smith EA, McDonough KA. 2011. Dysregulation of serine biosynthesis contributes to the growth defect of a Mycobacterium tuberculosis crp mutant. Mol. Microbiol. 82:180-198.
25. Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H. 2006. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2:2006-2008.
26. Mt), a cyclic AMP receptor protein-like DNA binding protein. J. Bacteriol. 187:7795-7804.
27. Bai Y, Yang J, Zhou X, Ding X, Eisele LE, Bai G. 2012. Mycobacterium tuberculosis Rv3586 (DacA) is a diadenylate cyclase that converts ATP or ADP into c-di-AMP. PLoS One 7:e35206. doi:10.1371/journal.pone.0035206.
28. Bai G, Gazdik MA, Schaak DD, McDonough KA. 2007. The Mycobacterium bovis BCG cyclic AMP receptor-like protein is a functional DNA binding protein in vitro and in vivo, but its activity differs from that of its M. tuberculosis ortholog, Rv3676. Infect. Immun. 75:5509-5517.
29. Datsenko KA, Wanner BL. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. U. S. A. 97:6640-6645.
30. Lanie JA, Ng WL, Kazmierczak KM, Andrzejewski TM, Davidsen TM, Wayne KJ, Tettelin H, Glass JI, Winkler ME. 2007. Genome sequence of Avery's virulent serotype 2 strain D39 of Streptococcus pneumoniae and comparison with that of unencapsulated laboratory strain R6. J. Bacteriol. 189:38-51.
31. Belitsky BR. 2004. Physical and enzymological interaction of Bacillus subtilis proteins required for de novo pyridoxal 5'-phosphate biosynthesis. J. Bacteriol. 186:1191-1196.
32. Dong YX, Sueda S, Nikawa J, Kondo H. 2004. Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae. Eur. J. Biochem. 271:745-752.
33. 6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights. J. Biol. Chem. 281:3633-3641.
34. 6 biosynthesis in higher plants. Proc. Natl. Acad. Sci. U. S. A. 102:13687-13692.
35. 6 biosynthesis pathway in the human malaria parasite Plasmodium falciparum. J. Biol. Chem. 280:5242-5248.
36. 6 biosynthetic gene of Cercospora nicotianae and pdxJ of Escherichia coli. FEBS Lett. 564:143-146.
37. Raschle T, Speziga D, Kress W, Moccand C, Gehrig P, Amrhein N, Weber-Ban E, Fitzpatrick TB. 2009. Intersubunit cross-talk in pyridoxal 5'-phosphate synthase, coordinated by the C terminus of the synthase subunit. J. Biol. Chem. 284:7706-7718.
38. 6 biosynthesis in Bacillus subtilis. J. Biosci. Bioeng. 93:309-312.
39. Belitsky BR. 2004. Bacillus subtilis GabR, a protein with DNA-binding and aminotransferase domains, is a PLP-dependent transcriptional regulator. J. Mol. Biol. 340:655-664.
40. Avery OT, Macleod CM, McCarty M. 1944. Studies on the chemical nature of the substance inducing transformation of pneumococcal types: induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III. J. Exp. Med. 79:137-158.