메뉴 건너뛰기




Volumn 12, Issue 10, 2013, Pages 1487-1491

Understanding impediments to cellular conversion to pluripotency by assessing the earliest events in ectopic transcription factor binding to the genome

Author keywords

c Myc; Chromatin; H3K9me3; Heterochromatin; Klf4; Oct4; Pioneer factors; Pluripotency; Reprogramming; Sox2

Indexed keywords

MYC PROTEIN; TRANSCRIPTION FACTOR; HETEROCHROMATIN; KRUPPEL LIKE FACTOR; KRUPPEL LIKE FACTOR 4; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN BINDING; TRANSCRIPTION FACTOR SOX;

EID: 84877963618     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.24663     Document Type: Review
Times cited : (13)

References (41)
  • 1
    • 0023663888 scopus 로고
    • Expression of a single transfected cDNA converts fibroblasts to myoblasts
    • PMID:3690668
    • Davis RL, Weintraub H, Lassar AB. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 1987; 51:987-1000; PMID:3690668; http://dx.doi.org/10.1016/0092-8674(87)90585-X
    • (1987) Cell , vol.51 , pp. 987-1000
    • Davis, R.L.1    Weintraub, H.2    Lassar, A.B.3
  • 2
    • 71449125977 scopus 로고    scopus 로고
    • Forcing cells to change lineages
    • PMID:19956253
    • Graf T, Enver T. Forcing cells to change lineages. Nature 2009; 462:587-94; PMID:19956253; http://dx.doi.org/10.1038/nature08533
    • (2009) Nature , vol.462 , pp. 587-594
    • Graf, T.1    Enver, T.2
  • 3
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • PMID:16904174
    • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126:663-76; PMID:16904174; http://dx.doi.org/10.1016/j.cell.2006.07.024
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 4
    • 84868202020 scopus 로고    scopus 로고
    • Epigenetic obstacles encountered by transcription factors: reprogramming against all odds
    • PMID:22922161
    • Gifford CA, Meissner A. Epigenetic obstacles encountered by transcription factors: reprogramming against all odds. Curr Opin Genet Dev 2012; 22:409-15; PMID:22922161; http://dx.doi.org/10.1016/j.gde.2012.08.002
    • (2012) Curr Opin Genet Dev , vol.22 , pp. 409-415
    • Gifford, C.A.1    Meissner, A.2
  • 5
    • 84870058502 scopus 로고    scopus 로고
    • Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome
    • PMID:23159369
    • Soufi A, Donahue G, Zaret KS. Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome. Cell 2012; 151:994-1004; PMID:23159369; http://dx.doi.org/10.1016/j.cell.2012.09.045
    • (2012) Cell , vol.151 , pp. 994-1004
    • Soufi, A.1    Donahue, G.2    Zaret, K.S.3
  • 6
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • PMID:18035408
    • Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131:861-72; PMID:18035408; http://dx.doi.org/10.1016/j.cell. 2007.11.019
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6
  • 7
    • 50849144675 scopus 로고    scopus 로고
    • A drug-inducible system for direct reprogramming of human somatic cells to pluripotency
    • PMID:18786421
    • Hockemeyer D, Soldner F, Cook EG, Gao Q, Mitalipova M, Jaenisch R. A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell 2008; 3:346-53; PMID:18786421; http://dx.doi.org/ 10.1016/j.stem.2008.08.014
    • (2008) Cell Stem Cell , vol.3 , pp. 346-353
    • Hockemeyer, D.1    Soldner, F.2    Cook, E.G.3    Gao, Q.4    Mitalipova, M.5    Jaenisch, R.6
  • 8
    • 58249085824 scopus 로고    scopus 로고
    • Role of the murine reprogramming factors in the induction of pluripotency
    • PMID:19167336
    • Sridharan R, Tchieu J, Mason MJ, Yachechko R, Kuoy E, Horvath S, et al. Role of the murine reprogramming factors in the induction of pluripotency. Cell 2009; 136:364-77; PMID:19167336; http://dx.doi.org/10.1016/j.cell.2009.01.001
    • (2009) Cell , vol.136 , pp. 364-377
    • Sridharan, R.1    Tchieu, J.2    Mason, M.J.3    Yachechko, R.4    Kuoy, E.5    Horvath, S.6
  • 9
    • 25144525014 scopus 로고    scopus 로고
    • Core transcriptional regulatory circuitry in human embryonic stem cells
    • PMID:16153702
    • Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005; 122:947-56; PMID:16153702; http://dx.doi.org/10.1016/j.cell.2005.08.020
    • (2005) Cell , vol.122 , pp. 947-956
    • Boyer, L.A.1    Lee, T.I.2    Cole, M.F.3    Johnstone, S.E.4    Levine, S.S.5    Zucker, J.P.6
  • 10
    • 44649117905 scopus 로고    scopus 로고
    • Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
    • PMID:18555785
    • Chen X, Xu H, Yuan P, Fang F, Huss M, Vega VB, et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008; 133:1106-17; PMID:18555785; http://dx.doi.org/10.1016/j. cell.2008.04.043
    • (2008) Cell , vol.133 , pp. 1106-1117
    • Chen, X.1    Xu, H.2    Yuan, P.3    Fang, F.4    Huss, M.5    Vega, V.B.6
  • 11
    • 40749104852 scopus 로고    scopus 로고
    • An extended transcriptional network for pluripotency of embryonic stem cells
    • PMID:18358816
    • Kim J, Chu J, Shen X, Wang J, Orkin SH. An extended transcriptional network for pluripotency of embryonic stem cells. Cell 2008; 132:1049-61; PMID:18358816; http://dx.doi.org/10.1016/j.cell.2008.02.039
    • (2008) Cell , vol.132 , pp. 1049-1061
    • Kim, J.1    Chu, J.2    Shen, X.3    Wang, J.4    Orkin, S.H.5
  • 12
    • 77957757417 scopus 로고    scopus 로고
    • A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs
    • PMID:20946988
    • Kim J, Woo AJ, Chu J, Snow JW, Fujiwara Y, Kim CG, et al. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 2010; 143:313-24; PMID:20946988; http://dx.doi.org/10.1016/j. cell.2010.09.010
    • (2010) Cell , vol.143 , pp. 313-324
    • Kim, J.1    Woo, A.J.2    Chu, J.3    Snow, J.W.4    Fujiwara, Y.5    Kim, C.G.6
  • 13
    • 79958292714 scopus 로고    scopus 로고
    • Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
    • PMID:21654807
    • Maekawa M, Yamaguchi K, Nakamura T, Shibukawa R, Kodanaka I, Ichisaka T, et al. Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1. Nature 2011; 474:225-9; PMID:21654807; http://dx.doi.org/10.1038/nature10106
    • (2011) Nature , vol.474 , pp. 225-229
    • Maekawa, M.1    Yamaguchi, K.2    Nakamura, T.3    Shibukawa, R.4    Kodanaka, I.5    Ichisaka, T.6
  • 14
    • 79953881831 scopus 로고    scopus 로고
    • Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency
    • PMID:21474102
    • Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, et al. Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell 2011; 8:376-88; PMID:21474102; http://dx.doi.org/ 10.1016/j.stem.2011.03.001
    • (2011) Cell Stem Cell , vol.8 , pp. 376-388
    • Anokye-Danso, F.1    Trivedi, C.M.2    Juhr, D.3    Gupta, M.4    Cui, Z.5    Tian, Y.6
  • 15
    • 77957551870 scopus 로고    scopus 로고
    • A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
    • PMID:20621050
    • Li R, Liang J, Ni S, Zhou T, Qing X, Li H, et al. A mesenchymal-to- epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 2010; 7:51-63; PMID:20621050; http://dx.doi.org/10.1016/j.stem.2010.04.014
    • (2010) Cell Stem Cell , vol.7 , pp. 51-63
    • Li, R.1    Liang, J.2    Ni, S.3    Zhou, T.4    Qing, X.5    Li, H.6
  • 16
    • 80455144479 scopus 로고    scopus 로고
    • Pioneer transcription factors: Establishing competence for gene expression
    • PMID:22056668
    • Zaret KS, Carroll JS. Pioneer transcription factors: establishing competence for gene expression. Genes Dev 2011; 25:2227-41; PMID:22056668; http://dx.doi.org/10.1101/gad.176826.111
    • (2011) Genes Dev , vol.25 , pp. 2227-2241
    • Zaret, K.S.1    Carroll, J.S.2
  • 17
    • 83255188897 scopus 로고    scopus 로고
    • Polycomb-repressed genes have permissive enhancers that initiate reprogramming
    • PMID:22153073
    • Taberlay PC, Kelly TK, Liu CC, You JS, De Carvalho DD, Miranda TB, et al. Polycomb-repressed genes have permissive enhancers that initiate reprogramming. Cell 2011; 147:1283-94; PMID:22153073; http://dx.doi.org/10.1016/j.cell.2011. 10.040
    • (2011) Cell , vol.147 , pp. 1283-1294
    • Taberlay, P.C.1    Kelly, T.K.2    Liu, C.C.3    You, J.S.4    De Carvalho, D.D.5    Miranda, T.B.6
  • 18
    • 84875609093 scopus 로고    scopus 로고
    • A central role for TFIID in the pluripotent transcription circuitry
    • PMID:23503660
    • Pijnappel WW, Esch D, Baltissen MP, Wu G, Mischerikow N, Bergsma AJ, et al. A central role for TFIID in the pluripotent transcription circuitry. Nature 2013; 495:516-9; PMID:23503660; http://dx.doi.org/10.1038/nature11970
    • (2013) Nature , vol.495 , pp. 516-519
    • Pijnappel, W.W.1    Esch, D.2    Baltissen, M.P.3    Wu, G.4    Mischerikow, N.5    Bergsma, A.J.6
  • 19
    • 84867021989 scopus 로고    scopus 로고
    • Transcriptional amplification in tumor cells with elevated c-Myc
    • PMID:23021215
    • Lin CY, Lovén J, Rahl PB, Paranal RM, Burge CB, Bradner JE, et al. Transcriptional amplification in tumor cells with elevated c-Myc. Cell 2012; 151:56-67; PMID:23021215; http://dx.doi.org/10.1016/j.cell.2012.08.026
    • (2012) Cell , vol.151 , pp. 56-67
    • Lin, C.Y.1    Lovén, J.2    Rahl, P.B.3    Paranal, R.M.4    Burge, C.B.5    Bradner, J.E.6
  • 20
    • 84867010006 scopus 로고    scopus 로고
    • c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells
    • PMID:23021216
    • Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W, et al. c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell 2012; 151:68-79; PMID:23021216; http://dx.doi.org/10.1016/j.cell.2012.08.033
    • (2012) Cell , vol.151 , pp. 68-79
    • Nie, Z.1    Hu, G.2    Wei, G.3    Cui, K.4    Yamane, A.5    Resch, W.6
  • 21
    • 69349100179 scopus 로고    scopus 로고
    • Suppression of induced pluripotent stem cell generation by the p53-p21 pathway
    • PMID:19668191
    • Hong H, Takahashi K, Ichisaka T, Aoi T, Kanagawa O, Nakagawa M, et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009; 460:1132-5; PMID:19668191; http://dx.doi.org/10.1038/nature08235
    • (2009) Nature , vol.460 , pp. 1132-1135
    • Hong, H.1    Takahashi, K.2    Ichisaka, T.3    Aoi, T.4    Kanagawa, O.5    Nakagawa, M.6
  • 22
    • 69349100455 scopus 로고    scopus 로고
    • Linking the p53 tumour suppressor pathway to somatic cell reprogramming
    • PMID:19668186
    • Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A, et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 2009; 460:1140-4; PMID:19668186; http://dx.doi.org/10.1038/nature08311
    • (2009) Nature , vol.460 , pp. 1140-1144
    • Kawamura, T.1    Suzuki, J.2    Wang, Y.V.3    Menendez, S.4    Morera, L.B.5    Raya, A.6
  • 23
    • 69349098273 scopus 로고    scopus 로고
    • Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
    • PMID:19668190
    • Utikal J, Polo JM, Stadtfeld M, Maherali N, Kulalert W, Walsh RM, et al. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 2009; 460:1145-8; PMID:19668190; http://dx.doi.org/10.1038/ nature08285
    • (2009) Nature , vol.460 , pp. 1145-1148
    • Utikal, J.1    Polo, J.M.2    Stadtfeld, M.3    Maherali, N.4    Kulalert, W.5    Walsh, R.M.6
  • 24
    • 78650996389 scopus 로고    scopus 로고
    • Reprogramming factor expression initiates widespread targeted chromatin remodeling
    • PMID:21211784
    • Koche RP, Smith ZD, Adli M, Gu H, Ku M, Gnirke A, et al. Reprogramming factor expression initiates widespread targeted chromatin remodeling. Cell Stem Cell 2011; 8:96-105; PMID:21211784; http://dx.doi.org/10.1016/j.stem.2010.12.001
    • (2011) Cell Stem Cell , vol.8 , pp. 96-105
    • Koche, R.P.1    Smith, Z.D.2    Adli, M.3    Gu, H.4    Ku, M.5    Gnirke, A.6
  • 25
    • 84865112255 scopus 로고    scopus 로고
    • The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming
    • PMID:22801502
    • Mansour AA, Gafni O, Weinberger L, Zviran A, Ayyash M, Rais Y, et al. The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature 2012; 488:409-13; PMID:22801502; http://dx.doi.org/10.1038/nature11272
    • (2012) Nature , vol.488 , pp. 409-413
    • Mansour, A.A.1    Gafni, O.2    Weinberger, L.3    Zviran, A.4    Ayyash, M.5    Rais, Y.6
  • 26
    • 59149083658 scopus 로고    scopus 로고
    • Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells
    • PMID:19151716
    • Wen B, Wu H, Shinkai Y, Irizarry RA, Feinberg AP. Large histone H3 lysine 9 dimethylated chromatin blocks distinguish differentiated from embryonic stem cells. Nat Genet 2009; 41:246-50; PMID:19151716; http://dx.doi.org/10.1038/ng. 297
    • (2009) Nat Genet , vol.41 , pp. 246-250
    • Wen, B.1    Wu, H.2    Shinkai, Y.3    Irizarry, R.A.4    Feinberg, A.P.5
  • 27
    • 84864297655 scopus 로고    scopus 로고
    • Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation
    • PMID:22795131
    • Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S, et al. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Mol Cell 2012; 47:203-14; PMID:22795131; http://dx.doi.org/10.1016/j.molcel.2012.06.010
    • (2012) Mol Cell , vol.47 , pp. 203-214
    • Chandra, T.1    Kirschner, K.2    Thuret, J.Y.3    Pope, B.D.4    Ryba, T.5    Newman, S.6
  • 28
    • 45149084413 scopus 로고    scopus 로고
    • Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
    • PMID:18463634
    • Guelen L, Pagie L, Brasset E, Meuleman W, Faza MB, Talhout W, et al. Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions. Nature 2008; 453:948-51; PMID:18463634; http://dx.doi.org/10.1038/ nature06947
    • (2008) Nature , vol.453 , pp. 948-951
    • Guelen, L.1    Pagie, L.2    Brasset, E.3    Meuleman, W.4    Faza, M.B.5    Talhout, W.6
  • 29
    • 79952264847 scopus 로고    scopus 로고
    • Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
    • PMID:21289626
    • Lister R, Pelizzola M, Kida YS, Hawkins RD, Nery JR, Hon G, et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature 2011; 471:68-73; PMID:21289626; http://dx.doi.org/10.1038/ nature09798
    • (2011) Nature , vol.471 , pp. 68-73
    • Lister, R.1    Pelizzola, M.2    Kida, Y.S.3    Hawkins, R.D.4    Nery, J.R.5    Hon, G.6
  • 30
    • 79955583542 scopus 로고    scopus 로고
    • Mapping and analysis of chromatin state dynamics in nine human cell types
    • PMID:21441907
    • Ernst J, Kheradpour P, Mikkelsen TS, Shoresh N, Ward LD, Epstein CB, et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 2011; 473:43-9; PMID:21441907; http://dx.doi.org/10.1038/nature09906
    • (2011) Nature , vol.473 , pp. 43-49
    • Ernst, J.1    Kheradpour, P.2    Mikkelsen, T.S.3    Shoresh, N.4    Ward, L.D.5    Epstein, C.B.6
  • 31
    • 84873310426 scopus 로고    scopus 로고
    • Genome-wide chromatin state transitions associated with developmental and environmental cues
    • PMID:23333102
    • Zhu J, Adli M, Zou JY, Verstappen G, Coyne M, Zhang X, et al. Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell 2013; 152:642-54; PMID:23333102; http://dx.doi.org/10.1016/j.cell. 2012.12.033
    • (2013) Cell , vol.152 , pp. 642-654
    • Zhu, J.1    Adli, M.2    Zou, J.Y.3    Verstappen, G.4    Coyne, M.5    Zhang, X.6
  • 32
    • 84863724616 scopus 로고    scopus 로고
    • An epigenetic silencing pathway controlling T helper 2 cell lineage commitment
    • PMID:22763435
    • Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, et al. An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature 2012; 487:249-53; PMID:22763435; http://dx.doi.org/10.1038/nature11173
    • (2012) Nature , vol.487 , pp. 249-253
    • Allan, R.S.1    Zueva, E.2    Cammas, F.3    Schreiber, H.A.4    Masson, V.5    Belz, G.T.6
  • 33
    • 84872572800 scopus 로고    scopus 로고
    • Developmentally regulated subnuclear genome reorganization restricts neural progenitor competence in Drosophila
    • PMID:23332748
    • Kohwi M, Lupton JR, Lai SL, Miller MR, Doe CQ. Developmentally regulated subnuclear genome reorganization restricts neural progenitor competence in Drosophila. Cell 2013; 152:97-108; PMID:23332748; http://dx.doi.org/10.1016/j. cell.2012.11.049
    • (2013) Cell , vol.152 , pp. 97-108
    • Kohwi, M.1    Lupton, J.R.2    Lai, S.L.3    Miller, M.R.4    Doe, C.Q.5
  • 34
    • 84859218238 scopus 로고    scopus 로고
    • Chromatin-modifying enzymes as modulators of reprogramming
    • PMID:22388813
    • Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature 2012; 483:598-602; PMID:22388813; http://dx.doi.org/10.1038/nature10953
    • (2012) Nature , vol.483 , pp. 598-602
    • Onder, T.T.1    Kara, N.2    Cherry, A.3    Sinha, A.U.4    Zhu, N.5    Bernt, K.M.6
  • 35
    • 84871990064 scopus 로고    scopus 로고
    • H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs
    • PMID:23202127
    • Chen J, Liu H, Liu J, Qi J, Wei B, Yang J, et al. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet 2013; 45:34-42; PMID:23202127; http://dx.doi.org/10.1038/ng.2491
    • (2013) Nat Genet , vol.45 , pp. 34-42
    • Chen, J.1    Liu, H.2    Liu, J.3    Qi, J.4    Wei, B.5    Yang, J.6
  • 36
    • 84866369892 scopus 로고    scopus 로고
    • Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase
    • PMID:22980981
    • Buganim Y, Faddah DA, Cheng AW, Itskovich E, Markoulaki S, Ganz K, et al. Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 2012; 150:1209-22; PMID:22980981; http://dx.doi.org/10.1016/j.cell.2012.08.023
    • (2012) Cell , vol.150 , pp. 1209-1222
    • Buganim, Y.1    Faddah, D.A.2    Cheng, A.W.3    Itskovich, E.4    Markoulaki, S.5    Ganz, K.6
  • 37
    • 71449109765 scopus 로고    scopus 로고
    • Direct cell reprogramming is a stochastic process amenable to acceleration
    • PMID:19898493
    • Hanna J, Saha K, Pando B, van Zon J, Lengner CJ, Creyghton MP, et al. Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 2009; 462:595-601; PMID:19898493; http://dx.doi.org/10.1038/nature08592
    • (2009) Nature , vol.462 , pp. 595-601
    • Hanna, J.1    Saha, K.2    Pando, B.3    Van Zon, J.4    Lengner, C.J.5    Creyghton, M.P.6
  • 38
    • 78149465975 scopus 로고    scopus 로고
    • A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity
    • PMID:20953172
    • Chia NY, Chan YS, Feng B, Lu X, Orlov YL, Moreau D, et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity. Nature 2010; 468:316-20; PMID:20953172; http://dx.doi.org/10.1038/nature09531
    • (2010) Nature , vol.468 , pp. 316-320
    • Chia, N.Y.1    Chan, Y.S.2    Feng, B.3    Lu, X.4    Orlov, Y.L.5    Moreau, D.6
  • 39
    • 76949089719 scopus 로고    scopus 로고
    • Dppa2 knock-down-induced differentiation and repressed proliferation of mouse embryonic stem cells
    • PMID:19846433
    • Du J, Chen T, Zou X, Xiong B, Lu G. Dppa2 knock-down-induced differentiation and repressed proliferation of mouse embryonic stem cells. J Biochem 2010; 147:265-71; PMID:19846433; http://dx.doi.org/10.1093/jb/mvp161
    • (2010) J Biochem , vol.147 , pp. 265-271
    • Du, J.1    Chen, T.2    Zou, X.3    Xiong, B.4    Lu, G.5
  • 40
    • 46449094276 scopus 로고    scopus 로고
    • Dissecting direct reprogramming through integrative genomic analysis
    • PMID:18509334
    • Mikkelsen TS, Hanna J, Zhang X, Ku M, Wernig M, Schorderet P, et al. Dissecting direct reprogramming through integrative genomic analysis. Nature 2008; 454:49-55; PMID:18509334; http://dx.doi.org/10.1038/nature07056
    • (2008) Nature , vol.454 , pp. 49-55
    • Mikkelsen, T.S.1    Hanna, J.2    Zhang, X.3    Ku, M.4    Wernig, M.5    Schorderet, P.6
  • 41
    • 84865486793 scopus 로고    scopus 로고
    • Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2
    • PMID:22902501
    • Doege CA, Inoue K, Yamashita T, Rhee DB, Travis S, Fujita R, et al. Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature 2012; 488:652-5; PMID:22902501; http://dx.doi.org/10.1038/ nature11333
    • (2012) Nature , vol.488 , pp. 652-655
    • Doege, C.A.1    Inoue, K.2    Yamashita, T.3    Rhee, D.B.4    Travis, S.5    Fujita, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.