PPAR-γ and tollip are associated with toll-like receptors in colitis rats

Journal of Immunoassay and Immunochemistry

Volumn 34, Issue 3, 2013, Pages 219-231

  Xu, Ning ^a   Yu, Zhen Hai ^b   Yao, Qing Shou ^b   Wang, Zhi Qiang ^b   Qu, Hong Lin ^b   Sun, Yi ^b   Liu, Jiao ^b   Jin, Chang Zhu ^b  

^a QINGDAO UNIVERSITY   (China)

^b BINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

colitis; NF bp65; PPAR ; TLRs; tollip

Indexed keywords

CELL MEMBRANE PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLLIP PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; CONTROLLED STUDY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LAMINA PROPRIA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCORING SYSTEM;

ANIMALS; COLITIS; GENE EXPRESSION REGULATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TRINITROBENZENESULFONIC ACID;

EID: 84877951715     PISSN: 15321819     EISSN: 15324230     Source Type: Journal    
DOI: 10.1080/15321819.2012.699490     Document Type: Article

References (24)

1. Hanauer, S. B. Inflammatory bowel disease: Epidemiology, pathogenesis, and therapeutic opportunities. Inflamm. Bowel Dis. 2006, 12(Suppl 1), S3-9. Review.
2. Cario, E.; Podolsky, D. K. Intestinal epithelial TOLLerance versus inTOLLerance of commensals. Mol. Immunol. 2005, 42(8), 887-893.
3. Wang, J. H.; Doyle, M.; Manning, B. J.; Di Wu, Q.; Blankson, S.; Redmond, H. P. Induction of bacterial lipoprotein tolerance is associated with suppression of toll-like receptor 2 expression. J. Biol. Chem. 2002, 277(39), 36068-36075.
4. Kumar, H.; Kawai, T.; Akira, S. Toll-like receptors and innate immunity. Biochem. Biophys. Res. Commun. 2009, 388(4), 621-625.
5. Cario, E.; Gerken, G.; Podolsky, D. K. Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function. Gastroenterology 2007, 132(4), 1359-1374.
6. Oshima, N.; Ishihara, S.; Rumi, M. A.; Aziz, M. M.; Mishima, Y.; Kadota, C.; Moriyama, I.; Ishimura, N.; Amano, Y.; Kinoshita, Y. A20 is an early responding negative regulator of toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin. Exp. Immunol. 2010, 159(2), 185-198.
7. Zhang, G.; Ghosh, S. Negative regulation of toll-like receptor-mediated signaling by tollip. J. Biol. Chem. 2002, 277(9), 7059-7065.
8. Song, Z.; Yin, J.; Yao, C.; Sun, Z.; Shao, M.; Zhang, Y.; Tao, Z.; Huang, P.; Tong, C. Variants in the toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han population. Crit. Care. 2011, 15(1), R12.
9. Fitzpatrick, L. R.; Meirelles, K.; Small, J. S.; Puleo, F. J.; Koltun, W. A.; Cooney, R. N. A new model of chronic hapten-induced colitis in young rats. J. Pediatr. Gastroenterol. Nutr. 2010, 50(3), 240-250.
10. Butzner, J. D.; Parmar, R.; Bell, C. J.; Dalal, V. Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat. Gut. 1996, 38(4), 568-573.
11. Akcan, A.; Muhtaroglu, S.; Akgun, H.; Akyildiz, H.; Kucuk, C.; Sozuer, E.; Yurci, A.; Yilmaz, N. Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats. World J. Gastroenterol. 2008, 14(8), 1222-1230.
12. Medzhitov, R.; Preston-Hurlburt, P.; Janeway, C. A. Jr. A human homologue of the drosophila toll protein signals activation of adaptive immunity. Nature 1997, 388(6640), 394-397.
13. Abreu, M. T. Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function. Nat. Rev. Immunol. 2010, 10(2), 131-144.
14. Suzuki, M.; Hisamatsu, T.; Podolsky, D. K. Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of LPS uptake and expression of the intracellular toll-like receptor 4-MD-2 complex. Infect. Immun. 2003, 71(6), 3503-3511.
15. Ungaro, R.; Fukata, M.; Hsu, D.; Hernandez, Y.; Breglio, K.; Chen, A.; Xu, R.; Sotolongo, J.; Espana, C.; Zaias, J.; Elson, G.; Mayer, L.; Kosco-Vilbois, M.; Abreu, M. T. A novel toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Amer. J. Physiol. Gastrointest. Liver Physiol. 2009, 296(6), G1167-1179.
16. Didierlaurent, A.; Brissoni, B.; Velin, D.; Aebi, N.; Tardivel, A.; Kaslin, E.; Sirard, J. C.; Angelov, G.; Tschopp, J.; Burns, K. Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol. Cell Biol. 2006, 26(3), 735-742.
17. Nishimura, M.; Naito, S. Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol. Pharm. Bull. 2005, 28(5), 886-892.
18. Otte, J. M.; Cario, E.; Podolsky, D. K. Mechanisms of cross hyporesponsiveness to toll-like receptor bacterial ligands in intestinal epithelial cells. Gastroenterology 2004, 126(4), 1054-1070.
19. Abreu, M. T.; Arnold, E. T.; Thomas, L. S.; Gonsky, R.; Zhou, Y.; Hu, B.; Arditi, M. TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells. J. Biol. Chem. 2002, 277(23), 20431-20437.
20. Shibolet, O.; Podolsky, D. K. TLRs in the gut. IV. Negative regulation of toll-like receptors and intestinal homeostasis: Addition by subtraction. Amer. J. Physiol. Gastrointest. Liver Physiol. 2007, 292(6), G1469-1473.
21. Steenholdt, C.; Andresen, L.; Pedersen, G.; Hansen, A.; Brynskov, J. Expression and function of toll-like receptor 8 and tollip in colonic epithelial cells from patients with inflammatory bowel disease. Scand. J. Gastroenterol. 2009, 44(2), 195-204.
22. Capelluto, D. G. Tollip: A multitasking protein in innate immunity and protein trafficking. Microbes Infect. 2011, 8(1), 1-8.
23. Adachi, M.; Kurotani, R.; Morimura, K.; Shah, Y.; Sanford, M.; Madison, B. B.; Gumucio, D. L.; Marin, H. E.; Peters, J. M.; Young, H. A.; Gonzalez, F. J. Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease. Gut 2006, 55(8), 1104-1113.
24. Ogawa, S.; Lozach, J.; Benner, C.; Pascual, G.; Tangirala, R. K.; Westin, S.; Hoffmann, A.; Subramaniam, S.; David, M.; Rosenfeld, M. G.; Glass, C. K. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 2005, 122(5), 707-721.