Hematopoietic stem cells and HIV infection

Journal of Infectious Diseases

Volumn 207, Issue 12, 2013, Pages 1790-1792

  Pace, Matthew ^a   O'Doherty, Una ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

hematopoietic stem cells; HIV infection

Indexed keywords

ANTIRETROVIRUS AGENT; CD133 ANTIGEN; CD4 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; GLYCOPROTEIN GP 120; VIRUS ENVELOPE PROTEIN;

EDITORIAL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VIRAL TROPISM; VIRUS CARRIER; VIRUS LOAD;

HEMATOPOIETIC STEM CELLS; HIV INFECTION;

ANTI-RETROVIRAL AGENTS; ANTIGENS, CD; GENOME, VIRAL; GLYCOPROTEINS; HEMATOPOIETIC STEM CELLS; HIV INFECTIONS; HIV-1; HUMANS; PEPTIDES;

EID: 84877939410     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jit120     Document Type: Editorial

References (13)

1. Bailey JR, Sedaghat AR, Kieffer T, et al. Residual human immunodeficiency virus type 1 viremia in some patients on antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells. J Virol 2006; 80:6441-57.
2. Brennan TP, Woods JO, Sedaghat AR, Sili-ciano JD, Siliciano RF, Wilke CO. Analysis of human immunodeficiency virus type 1 viremia and provirus in resting CD4+ T cells reveals a novel source of residual viremia in patients on antiretroviral therapy. J Virol 2009; 83:8470-81.
3. Richman DD, Margolis DM, Delaney M, Greene WC, Hazuda D, Pomerantz RJ. The challenge of finding a cure for HIV infection. Science 2009; 323:1304-7.
4. McNamara LA, Collins KL. Hematopoietic stem/precursor cells as HIV reservoirs. Curr Opin HIVAIDS 2011; 6:43-8.
5. Durand CM, Ghiaur G, Siliciano JD, et al. HIV-1 DNA is detected in bone marrow populations containing CD4+ T cells but is not found in purified CD34+ hematopoietic progenitor cells in most patients on antiretro-viral therapy. J Infect Dis 2012; 205:1014-8.
6. Josefsson L, Eriksson S, Sinclair E, et al. He-matopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA. J Infect Dis 2012; 206:28-34.
7. + hematopoietic progenitor cells harbor HIV genomes in a subset of optimally treated people with long-term viral suppression. J Infect Dis 2013. In this issue.
8. Carter CC, Onafuwa-Nuga A, McNamara LA, et al. HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs. Nat Med 2010; 16:446-51.
9. Carter CC, McNamara LA, Onafuwa-Nuga A, et al. HIV-1 utilizes the CXCR4 chemo-kine receptor to infect multipotent hemato-poietic stem and progenitor cells. Cell Host Microbe 2011; 9:223-34.
10. Louache F, Debili N, Marandin A, Coulom-bel L, Vainchenker W. Expression of CD4 by human hematopoietic progenitors. Blood 1994; 84:3344-55.
11. Kabat D, Kozak SL, Wehrly K, Chesebro B. Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1. J Virol 1994; 68:2570-7.
12. Murray JM, McBride K, Boesecke C, et al. Integrated HIV DNA accumulates prior to treatment while episomal HIV DNA records ongoing transmission afterwards. AIDS 2012; 26:543-50.
13. Notta F, Doulatov S, Laurenti E, Poeppl A, Jurisica I, Dick JE. Isolation of single human hematopoietic stem cells capable of longterm multilineage engraftment. Science 2011; 333:218-21.