Commentary on research of bone morphogenetic protein discussed in review article: Genetic advances in the regeneration of the intervertebral disc

Surgical Neurology International

Volumn 4, Issue SUPPL.2, 2013, Pages

  Epstein, Nancy ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b WINTHROP UNIVERSITY HOSPITAL   (United States)

Author keywords

Animal laboratory studies; bone morphogenetic protein; clinical; infuse; intervertebral disc; regeneration; spinal surgery

Indexed keywords

COLLAGEN TYPE 1; INFUSE; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT OSTEOGENIC PROTEIN 1; UNCLASSIFIED DRUG;

ANTERIOR SPINE FUSION; APOPTOSIS; BONE REGENERATION; CELL PROLIFERATION; CERVICAL SPINE; CHONDROGENESIS; DRUG APPROVAL; DRUG EFFICACY; DRUG RESEARCH; DRUG SAFETY; FOOD AND DRUG ADMINISTRATION; FUSION DEVICE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTERVERTEBRAL DISK; LUMBAR SPINE; MEDICAL RESEARCH; NONHUMAN; OFF LABEL DRUG USE; ORTHOPEDIC SURGICAL EQUIPMENT; PEROPERATIVE COMPLICATION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RISK ASSESSMENT; SPINE DISEASE; THORACIC SPINE;

EID: 84877934164     PISSN: None     EISSN: 21527806     Source Type: Journal    
DOI: 10.4103/2152-7806.109452     Document Type: Review

References (7)

1. Huang B, Zhuang Y, Li CQ, Liu LT, Zhou Y. Regeneration of the intervertebral disc with nucleus pulposus cell-seeded collagen II/hyaluronan/chondroitin-6-sulfate tri-copolymer constructs in a rabbit disc degeneration model. Spine (Phila Pa 1976) 2011;36:2252-9.
2. Kim DJ, Moon SH, Kim H, Kwon UH, Park MS, Han KJ, et al. Bone morphogenetic protein-2 facilitates expression of chondrogenic, not osteogenic, phenotype of human intervertebral disc cells. Spine (Phila Pa 1976) 2003;28:2679-84.
3. Maerz T, Harry Herkowitz H, Kevin Baker K. Review article: Molecular and genetic advances in the regeneration of the intervertebral disc. Surgical Neurology International: Spine Supplement 2013. [In press]
4. McCanless JD, Cole JA, Slack SM, Bumgardner JD, Zamora PO, Haggard WO. Modeling nucleus pulposus regeneration in vitro: Mesenchymal stem cells, alginate beads, hypoxia, bone morphogenetic protein-2, and synthetic peptide B2A. Spine (Phila Pa 1976) 2011;36:2275-85.
5. Walsh AJ, Bradford DS, Lotz JC. In vivo growth factor treatment of degenerated intervertebral discs. Spine (Phila Pa 1976) 2004;29:156-63.
6. Wang H, Kroeber M, Hanke M, Ries R, Schmid C, Poller W, et al. Release of active and depot GDF-5 after adenovirus-mediated overexpression stimulates rabbit and human intervertebral disc cells. J Mol Med (Berl) 2004;82:126-34.
7. Watts C. Off-label use of rhBMP-2. Surg Neurol Int 2011;2:4.