The identification of free cysteine residues within antibodies and a potential role for free cysteine residues in covalent aggregation because of agitation stress

Journal of Pharmaceutical Sciences

Volumn 102, Issue 6, 2013, Pages 1701-1711

  Huh, Joon H ^a   White, April J ^a   Brych, Stephen R ^a   Franey, Heather ^a   Matsumura, Masazumi ^a  

^a AMGEN INC   (United States)

Author keywords

Disulfide bonds; Free cysteine; IgG1; IgG2; Mass spectrometry; Protein aggregation; Protein folding; Protein structure; Stability

Indexed keywords

CYSTEINE; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2 ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; COVALENT BOND; DISULFIDE BOND; FLUORESCENCE ANALYSIS; MASS SPECTROMETRY; PROTEIN AGGREGATION; PROTEIN DOMAIN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 84877922131     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23505     Document Type: Article

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