Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study

BMC Gastroenterology

Volumn 13, Issue 1, 2013, Pages

  Kuramoto, Takanori ^a   Umegaki, Eiji ^a   Nouda, Sadaharu ^a   Narabayashi, Ken ^a   Kojima, Yuichi ^a   Yoda, Yukiko ^a   Ishida, Kumi ^a   Kawakami, Ken ^a   Abe, Yosuke ^a   Takeuchi, Toshihisa ^a   Inoue, Takuya ^a   Murano, Mitsuyuki ^a   Tokioka, Satoshi ^a   Higuchi, Kazuhide ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Irsogladine; NSAIDs; Omeprazole; Small intestinal injury

Indexed keywords

CALGRANULIN; IRSOGLADINE MALEATE; OMEPRAZOLE;

ADULT; ARTICLE; CAPSULE ENDOSCOPY; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG INDUCED DISEASE; ESOPHAGITIS; ESOPHAGOGASTRODUODENOSCOPY; FECES LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; INTESTINE INJURY; MALE; NORMAL HUMAN; OCCULT BLOOD; PEPTIC ULCER; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; DICLOFENAC; ENDOSCOPY, GASTROINTESTINAL; ESOPHAGITIS; FECES; FEMALE; HUMANS; INTESTINAL MUCOSA; INTESTINE, SMALL; LEUKOCYTE L1 ANTIGEN COMPLEX; MALE; OCCULT BLOOD; OMEPRAZOLE; PEPTIC ULCER; TRIAZINES; YOUNG ADULT;

EID: 84877902209     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-13-85     Document Type: Article

References (20)

1. Allison MC, Howatson AG, Torrance CJ, Lee FD, Russell RI. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. N Engl J Med 1992, 327:749-754. 10.1056/NEJM199209103271101, 1501650.
2. Kameda N, Higuchi K, Shiba M, Machida H, Okazaki H, Yamagami H, Tanigawa T, Watanabe K, Watanabe T, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T. A prospective, single-blind trial comparing wireless capsule endoscopy and double-balloon enteroscopy in patients with obscure gastrointestinal bleeding. J Gastroenterol 2008, 43:434-440. 10.1007/s00535-008-2182-9, 18600387.
3. Graham DY, Opekun AR, Willingham FF, Qureshi WA. Visible small-intestinal mucosal injury in chronic NSAID users. Clin Gastroenterol Hepatol 2005, 3:55-59. 10.1016/S1542-3565(04)00603-2, 15645405.
4. Goldstein JL, Eisen GM, Lewis B, Gralnek IM, Zlotnick S, Fort JG. Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol 2005, 3:133-141. 10.1016/S1542-3565(04)00619-6, 15704047.
5. Higuchi K, Umegaki E, Watanabe T, Yoda Y, Morita E, Murano M, Tokioka S, Arakawa T. Present status and strategy of NSAIDs-induced small bowel injury. J Gastroenterol 2009, 44:879-888. 10.1007/s00535-009-0102-2, 19568687.
6. Ueda F, Kyoi T, Mimura K, Kimura K, Yamamoto M. Intercellular communication in cultured rabbit gastric epithelial cells. Jpn J Pharmacol 1991, 57:321-328. 10.1254/jjp.57.321, 1667533.
7. Yoda Y, Takeuchi K, Kato S, Amagase K, Umegaki E, Tokioka S, Higuchi K. Search for prophylactic drugs against NSAID-induced small intestinal lesions in rats. Gastroenterology 2008, 134(Suppl 1):A-528.
8. Niwa Y, Nakamura M, Ohmiya N, Maeda O, Ando T, Itoh A, Hirooka Y, Goto H. Efficacy of rebamipide for diclofenac-induced small-intestinal mucosal injuries in healthy subjects: a prospective, randomized, double-blinded, placebo-controlled, cross-over study. J Gastroenterol 2008, 43:270-276. 10.1007/s00535-007-2155-4, 18458842.
9. Fujimori S, Seo T, Gudis K, Ehara A, Kobayashi T, Mitsui K, Yonezawa M, Tanaka S, Tatsuguchi A, Sakamoto C. Prevention of nonsteroidal anti-inflammatory drug-induced small-intestinal injury by prostaglandin: a pilot randomized controlled trial evaluated by capsule endoscopy. Gastrointest Endosc 2009, 69:1339-1346. 10.1016/j.gie.2008.08.017, 19243767.
10. Fujimori S, Takahashi Y, Gudis K, Seo T, Ehara A, Kobayashi T, Mitsui K, Yonezawa M, Tanaka S, Tatsuguchi A, Sakamoto C. Rebamipide has the potential to reduce the intensity of NSAID-induced small intestinal injury: a double-blind, randomized, controlled trial evaluated by capsule endoscopy. J Gastroenterol 2011, 46:57-64. 10.1007/s00535-010-0332-3, 20924615.
11. Nouda S, Morita E, Murano M, Imoto A, Kuramoto T, Inoue T, Murano N, Toshina K, Umegaki E, Higuchi K. Usefulness of polyethylene glycol solution with dimethylpolysiloxanes for bowel preparation before capsule endoscopy. J Gastroenterol Hepatol 2010, 25:70-74. 10.1111/j.1440-1746.2009.05968.x, 19793169.
12. Lanza FL, Graham DY, Davis RE, Rack MF. Endoscopic comparison of cimetidine and sucralfate for prevention of naproxen-induced acute gastroduodenal injury. Effect of scoring method. Dig Dis Sci 1990, 35:1494-1499. 10.1007/BF01540567, 2253535.
13. Langhorst J, Elsenbruch S, Mueller T, Rueffer A, Spahn G, Michalsen A, Dobos GJ. Comparison of 4 neutrophil-derived proteins in feces as indicators of disease activity in ulcerative colitis. Inflamm Bowel Dis 2005, 11:1085-1091. 10.1097/01.MIB.0000187980.08686.18, 16306771.
14. Tøn H, Brandsnes, Dale S, Holtlund J, Skuibina E, Schjønsby H, Johne B. Improved assay for fecal calprotectin. Clin Chim Acta 2000, 292:41-54. 10.1016/S0009-8981(99)00206-5, 10686275.
15. Sato M, Manabe N, Hata J, Ishii M, Kamada T, Kusunoki H, Shiotani A, Haruma K. Effect of irsogladine maleate on NSAID-induced reduction of gastric mucosal blood flow in anesthetized dogs. Digestion 2009, 79:73-78. 10.1159/000206823, 19270456.
16. Kyoi T, Noda K, Oka M, Ukai Y. Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. Life Sci 2004, 76:71-83. 10.1016/j.lfs.2004.06.016, 15501481.
17. Morita H, Katsuno T, Hoshimoto A, Hatakeyama K, Suzuki Y, Saito Y. Irsogladine, an activator of gap-junctional intercellular communication, suppresses paracellular permeability of human intestinal epithelial cell monolayers through up-regulation of claudin-4. Gastroenterology 2006, 130(Suppl 2):241.
18. Watanabe T, Sugimori S, Kameda N, Machida H, Okazaki H, Tanigawa T, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Higuchi K, Arakawa T. Small bowel injury by low-dose enteric-coated aspirin and treatment with misoprostol: a pilot study. Clin Gastroenterol Hepatol 2008, 6:1279-1282. 10.1016/j.cgh.2008.06.021, 18995219.
19. Hiraishi H, Haruma K, Miwa H, Goto H. Clinical trial: irsogladine maleate, a mucosal protective drug, accelerates gastric ulcer healing after treatment for eradication of Helicobacter pylori infection - the results of a multicentre, double-blind, randomized clinical trial (IMPACT study). Aliment Pharmacol Ther 2010, 31:824-833.
20. Wallace JL, Syer S, Denou E, de Palma G, Vong L, McKnight W, Jury J, Bolla M, Bercik P, Collins SM, Verdu E, Ongini E. Proton pump inhibitors exacerbate NSAID-induced small intestinal injury by inducing dysbiosis. Gastroenterology 2011, 141:1314-1322. 10.1053/j.gastro.2011.06.075, 21745447.