Clinical Effectiveness of Hymenoptera Venom Immunotherapy: A Prospective Observational Multicenter Study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Ruëff, Franziska ^a   Przybilla, Bernhard ^a   Biló, Maria Beatrice ^b   Müller, Ulrich ^c   Scheipl, Fabian ^d   Seitz, Michael J ^d   Aberer, Werner ^e   Bodzenta Lukaszyk, Anna ^f   Bonifazi, Floriano ^b   Campi, Paolo ^g   Darsow, Ulf ^h   Haeberli, Gabrielle ^c   Hawranek, Thomas ⁱ   Küchenhoff, Helmut ^d   Lang, Roland ⁱ   Quercia, Oliviero ^j   Reider, Norbert ^k   Schmid Grendelmeier, Peter ^l   Severino, Maurizio ^g   Sturm, Gunter Johannes ^e   Treudler, Regina ^m   Wüthrich, Brunello ^l   more..

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b OSPEDALI RIUNITI   (Italy)

^c Spitalnetz Bern   (Switzerland)

^d UNIVERSITY OF MUNICH   (Germany)

^e MEDICAL UNIVERSITY OF GRAZ   (Austria)

^f MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^g SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

^h TECHNICAL UNIVERSITY OF MUNICH   (Germany)

ⁱ PARACELSUS MEDICAL UNIVERSITY   (Austria)

^j Ospedale per gli Infermi di Faenza   (Italy)

^k INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^l UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^m UNIVERSITY HOSPITAL LEIPZIG   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIHISTAMINIC AGENT; BEE VENOM; CORTICOSTEROID; HYMENOPTERA VENOM; TRYPTASE;

ADULT; ARTICLE; BEE STING; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFICACY; DRUG TREATMENT FAILURE; DRUG USE; ENZYME BLOOD LEVEL; FEMALE; HUMAN; IMMUNOTHERAPY; INSECT ALLERGY; MAINTENANCE DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OBSERVATIONAL STUDY; PROSPECTIVE STUDY; RISK FACTOR; SYMPTOM; TREATMENT DURATION; VENOM IMMUNOTHERAPY;

ADULT; ANAPHYLAXIS; ANIMALS; BEE VENOMS; BEES; DESENSITIZATION, IMMUNOLOGIC; FEMALE; HUMANS; INSECT BITES AND STINGS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RISK FACTORS; ROC CURVE; TREATMENT FAILURE; WASP VENOMS; WASPS;

EID: 84877886934     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063233     Document Type: Article

References (35)

1. Ruëff F, Przybilla B, Biló MB, Müller U, Scheipl F, et al. (2009) Predictors of severe systemic anaphylactic reactions in Hymenoptera venom allergy: the importance of baseline serum tryptase. J Allergy Clin Immunol 124: 1047-1054.
2. Valent P, Akin C, Arock M, Brockow K, Butterfield JH, et al. (2012) Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal. Int Arch Allergy Immunol 157: 215-225.
3. Hidvégi B, Nagy E, Szabó T, Temesvári E, Marschalkó M, et al. (2003) Correlation between T-cell and mast cell activity in patients with chronic urticaria. Int Arch Allergy Immunol 132: 177-182.
4. Dugas-Breit S, Schöpf P, Dugas M, Schiffl H, Ruëff F, et al. (2005) Baseline serum levels of mast cell tryptase are raised in hemodialysis patients and associated with severity of pruritus. J Dtsch Dermatol Ges 3: 343-347.
5. Kawakami T, Kitaura J, (2005) Mast cell survival and activation by IgE in the absence of antigen: a consideration of the biologic mechanisms and relevance. J Immunol 175: 4167-4173.
6. Blum S, Gunzinger A, Müller UR, Helbling A, (2011) Influence of total and specific IgE, serum tryptase, and age on severity of allergic reactions to Hymenoptera stings. Allergy 66: 222-228.
7. Ruëff F, Przybilla B, Biló MB, Müller U, Scheipl F, et al. (2010) European Academy of Allergy and Clinical Immunology Interest Group. Predictors of side effects during the buildup phase of venom immunotherapy for Hymenoptera venom allergy: the importance of baseline serum tryptase. J Allergy Clin Immunol 126: 105-111.
8. Golden DB, Moffitt J, Nicklas RA, Freeman T, Graft DF, et al. (2011) Joint Task Force on Practice Parameters; American Academy of Allergy, Asthma & Immunology (AAAAI); American College of Allergy, Asthma & Immunology (ACAAI); Joint Council of Allergy, Asthma and Immunology. Stinging insect hypersensitivity: a practice parameter update 2011. J Allergy Clin Immunol 127: 852-854.
9. Haeberli G, Brönnimann M, Hunziker T, Müller U, (2003) Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy. Clin Exp Allergy 33: 1216-1220.
10. Niedoszytko M, de Monchy J, van Doormaal JJ, Jassem E, Oude Elberink JN, (2009) Mastocytosis and insect venom allergy: diagnosis, safety and efficacy of venom immunotherapy. Allergy 64: 1237-1245.
11. Bonifazi F, Jutel M, Biló BM, Birnbaum J, Müller U, (2005) EAACI Interest Group on Insect Venom Hypersensitivity. Prevention and treatment of hymenoptera venom allergy: guidelines for clinical practice. Allergy 60: 1459-1470.
12. Bonadonna P, Zanotti R, Müller U, (2010) Mastocytosis and insect venom allergy. Curr Opin Allergy Clin Immunol 10: 347-353.
13. Ruëff F, Przybilla B, Müller U, Mosbech H, (1996) The sting challenge test in Hymenoptera venom allergy. Position paper of the Subcommittee on Insect Venom Allergy of the European Academy of Allergology and Clinical Immunology. Allergy 51: 216-225.
14. Przybilla B, Ruëff F, (2010) Hymenoptera venom allergy. J Dtsch Dermatol Ges 8: 114-127.
15. Müller U, Mosbech H, Blaauw P, Dreborg S, Malling HJ, et al. (1991) Emergency treatment of allergic reactions to Hymenoptera stings. Clin Exp Allergy 21: 281-288.
16. Ring J, Meßmer K, (1977) Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet 1: 466-469.
17. Worm M, Edenharter G, Ruëff F, Scherer K, Pföhler C, et al. (2012) Symptom profile and risk factors of anaphylaxis in Central Europe. Allergy 67: 691-698.
18. Wood SN. mgcv: GAMs with GCV/AIC/REML Smoothness Estimation and GAMMs by PQL. Available: http://stat.ethz.ch/R-manual/R-devel/library/mgcv/html/mgcv-package.html. Accessed 2013 Apr 24.
19. Wood SN (2006) Generalized Additive Models: An Introduction with R. Chapman & Hall/CRC.
20. R Development Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. Version 2.14.2; Available: http://www.r-project.org. Accessed 2013 Apr 24.
21. Roca-Pardinas J, Cadarso-Suarez C, Tahoces PG, Lado MJ, (2008) Selecting variables in non-parametric regression models for binary response. An application to the computerized detection of breast cancer. Statistics in Medicine 28: 240-259.
22. Elremeli M, Bulsara Max K, Daniels M, Boyle RJ (2010) Venom immunotherapy for preventing allergic reactions to insect stings. Cochrane Database Syst Rev; DOI: 10.1002/14651858.CD008838.
23. Watanabe AS, Fonseca LA, Galvao CE, Kalil J, Castro FF, (2010) Specific immunotherapy using Hymenoptera venom: systematic review. Sao Paulo Med J 128: 30-37.
24. Ross RN, Nelson HS, Finegold I, (2000) Effectiveness of specific immunotherapy in the treatment of hymenoptera venom hypersensitivity: a meta-analysis. Clin Ther 22: 351-358.
25. Hockenhull J, Elremeli M, Cherry MG, Mahon J, Lai M, et al. (2012) A systematic review of the clinical effectiveness and cost-effectiveness of Pharmalgen® for the treatment of bee and wasp venom allergy. Health Technol Assess; 16: III-IV, 1-110.
26. Lockey RF, Turkeltaub PC, Baird-Warren IA, Olive CA, Olive ES, et al. (1988) The Hymenoptera venom study I, 1979-1982: demographics and history-sting data. J Allergy Clin Immunol 82: 370-381.
27. Solley GO, (2004) Stinging and biting insect allergy: an Australian experience. Ann Allergy Asthma Immunol 93: 532-537.
28. Redelmeier DA, Dickinson VM, (2011) Determining whether a patient is feeling better: pitfalls from the science of human perception. J Gen Intern Med. 26: 900-906.
29. Hassan E (2006) Recall Bias can be a threat to retrospective and prospective research designs. Internet J Epidemiol. The Internet Journal of Epidemiology 3. DOI: 10.5580/2732.
30. Golden DB, Breisch NL, Hamilton RG, Guralnick MW, Greene A, et al. (2006) Clinical and entomological factors influence the outcome of sting challenge studies. J Allergy Clin Immunol 117: 670-675.
31. Krishna MT, Ewan PW, Diwakar L, Durham SR, Frew AJ, et al. (2011) British Society for Allergy and Clinical Immunology. Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines. Clin Exp Allergy 41: 1201-1220.
32. Worm M, Hompes S, (2012) [The registry for severe allergic reactions in German-speaking countries. Recent data and perspectives]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55: 380-384.
33. Goldberg A, Confino-Cohen R, (2010) Bee venom immunotherapy- how early is it effective? Allergy 65: 391-395.
34. Sargur R, Cowley D, Murng S, Wild G, Green K, et al. (2011) Raised tryptase without anaphylaxis or mastocytosis: heterophilic antibody interference in the serum tryptase assay. Clin Exp Immunol 163: 339-345.
35. Van Toorenenbergen AW, van Daele PL, Boonstra JG, (2005) False-elevated serum tryptase assay result caused by heterophilic antibodies. J Allergy Clin Immunol 116: 1159-1160.