A naturally occurring single amino acid substitution in human TRIM5α linker region affects its anti-HIV type 1 activity and susceptibility to HIV type 1 infection

AIDS Research and Human Retroviruses

Volumn 29, Issue 6, 2013, Pages 919-924

  Nakayama, Emi E ^a   Nakajima, Toshiaki ^b   Kaur, Gurvinder ^c   Mimaya, Jun Ich ^d   Terunuma, Hiroshi ^e   Mehra, Narinder ^c   Kimura, Akinori ^b   Shioda, Tatsuo ^a  

^a OSAKA UNIVERSITY   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^d SHIZUOKA CHILDREN'S HOSPITAL   (Japan)

^e Biotherapy Institute of Japan   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CAPSID PROTEIN; GLYCINE; TRIPARTITE MOTIF PROTEIN 5;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; INDIAN; INFECTION SENSITIVITY; JAPANESE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS ATTENUATION; VIRUS REPLICATION;

AMINO ACID SUBSTITUTION; ANIMALS; BLOTTING, WESTERN; CARRIER PROTEINS; CLONING, MOLECULAR; CONTINENTAL POPULATION GROUPS; DISEASE SUSCEPTIBILITY; EXONS; GENOTYPE; HIV INFECTIONS; HIV-1; HUMANS; MACACA MULATTA; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84877870411     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2012.0369     Document Type: Article

References (33)

1. Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, and Sodroski J: The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys. Nature 2004;427:848-853
2. Stremlau M, Perron M, Lee M, et al.: Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor. Proc Natl Acad Sci USA 2006;103: 5514-5519
3. Perron MJ, Stremlau M, Song B, Ulm W, Mulligan RC, and Sodroski J: TRIM5alpha mediates the postentry block to Ntropic murine leukemia viruses in human cells. Proc Natl Acad Sci USA 2004;101:11827-11832
4. Yap MW, Nisole S, Lynch C, and Stoye JP: Trim5alpha protein restricts both HIV-1 and murine leukemia virus. Proc Natl Acad Sci USA 2004;101:10786-10791
5. Perez-Caballero D, Hatziioannou T, Yang A, Cowan S, and Bieniasz PD: Human tripartite motif 5alpha domains responsible for retrovirus restriction activity and specificity. J Virol 2005;79:8969-8978
6. Sawyer SL, Wu LI, Emerman M, and Malik HS: Positive selection of primate TRIM5alpha identifies a critical speciesspecific retroviral restriction domain. Proc Natl Acad Sci USA 2005;102:2832-2837
7. Stremlau M, Perron M, Welikala S, and Sodroski J: Speciesspecific variation in the B30.2(SPRY) domain of TRIM5alpha determines the potency of human immunodeficiency virus restriction. J Virol 2005;79:3139-3145
8. Yap MW, Nisole S, and Stoye JP: A single amino acid change in the SPRY domain of human Trim5alpha leads to HIV-1 restriction. Curr Biol 2005;15:73-78
9. Nakayama EE, Miyoshi H, Nagai Y, and Shioda T: A specific region of 37 amino acid residues in the SPRY (B30.2) domain of African green monkey TRIM5alpha determines speciesspecific restriction of simian immunodeficiency virus SIVmac infection. J Virol 2005;79:8870-8877
10. Kono K, Song H, Shingai Y, Shioda T, and Nakayama EE: Comparison of anti-viral activity of rhesus monkey and cynomolgus monkey TRIM5alphas against human immunodeficiency virus type 2 infection. Virology 2008;373: 447-456
11. Perron MJ, Stremlau M, and Sodroski J: Two surfaceexposed elements of the B30.2/SPRY domain as potency determinants of N-Tropic murine leukemia virus restriction by human TRIM5alpha. J Virol 2006;80:5631-5636
12. O'Brien SJ and Nelson GW: Human genes that limit AIDS. Nat Genet 2004;36:565-574
13. Shioda T and Nakayama EE: Human genetic polymorphisms affecting HIV-1 diseases. Int J Hematol 2006;84:12-17
14. Javanbakht H, An P, Gold B, et al.: Effects of human TRIM5alpha polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection. Virology 2006;354:15-27
15. Price H, Lacap P, Tuff J, et al.: A TRIM5alpha exon 2 polymorphism is associated with protection from HIV-1 infection in the Pumwani sex worker cohort. AIDS 2010;24: 1813-1821
16. Sawyer SL, Wu LI, Akey JM, Emerman M, and Malik HS: High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans. Curr Biol 2006;16:95-100
17. Speelmon EC, Livingston-Rosanoff D, Li SS, et al.: Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection. J Virol 2006;80:2463-2471
18. Goldschmidt V, Bleiber G, May M, Martinez R, Ortiz M, and Telenti A: Role of common human TRIM5alpha variants in HIV-1 disease progression. Retrovirology 2006;3:54
19. van Manen D, Rits MA, Beugeling C, van Dort K, Schuitemaker H, and Kootstra NA: The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection. PLoS Pathog 2008;4:e18
20. Nakayama EE, Carpentier W, Costagliola D, et al.: Wild type and H43Y variant of human TRIM5alpha show similar antihuman immunodeficiency virus type 1 activity both in vivo and in vitro. Immunogenetics 2007;59:511-515
21. Nakajima T, Nakayama EE, Kaur G, et al.: Impact of novel TRIM5alpha variants, Gly110Arg and G176del, on the anti-HIV-1 activity and the susceptibility to HIV-1 infection. AIDS 2009;23:2091-2100
22. Song H, Nakayama EE, Yokoyama M, Sato H, Levy JA, and Shioda T: A single amino acid of the human immunodeficiency virus type 2 capsid affects its replication in the presence of cynomolgus monkey and human TRIM5alphas. J Virol 2007;81:7280-7285
23. Nakayama EE, Tanaka Y, Nagai Y, Iwamoto A, and Shioda T: A CCR2-V64I polymorphism affects stability of CCR2A isoform. AIDS 2004;18:729-738
24. Miyoshi H, Takahashi M, Gage FH, and Verma IM: Stable and efficient gene transfer into the retina using an HIVbased lentiviral vector. Proc Natl Acad Sci USA 1997;94: 10319-10323
25. Miyoshi H, Blomer U, Takahashi M, Gage FH, and Verma IM: Development of a self-inactivating lentivirus vector. J Virol 1998;72:8150-8157
26. Kuroishi A, Bozek K, Shioda T, and Nakayama EE: A single amino acid substitution of the human immunodeficiency virus type 1 capsid protein affects viral sensitivity to TRIM5 alpha. Retrovirology 2010;7:58
27. Miyamoto T, Nakayama EE, Yokoyama M, et al.: The carboxyl-Terminus of human immunodeficiency virus type 2 circulating recombinant form 01-AB capsid protein affects sensitivity to human TRIM5alpha. PLoS One 2012;7:e47757
28. Munkanta M, Terunuma H, Takahashi M, et al.: HLA-B polymorphism in Japanese HIV-1-infected long-Term surviving hemophiliacs. Viral Immunol 2005;18:500-505
29. Nakajima T, Ohtani H, Naruse T, et al.: Copy number variations of CCL3L1 and long-Term prognosis of HIV-1 infection in asymptomatic HIV-infected Japanese with hemophilia. Immunogenetics 2007;59:793-798
30. Maegawa H, Nakayama EE, Kuroishi A, and Shioda T: Silencing of tripartite motif protein (TRIM) 5alpha mediated anti-HIV-1 activity by truncated mutant of TRIM5alpha. J Virol Methods 2008;151:249-256
31. Chou PY and Fasman GD: Prediction of the secondary structure of proteins from their amino acid sequence. Adv Enzymol Relat Areas Mol Biol 1978;47:45-48
32. Akagi T, Ohtsuki Y, Shiraishi Y, and Miyoshi I: Transformation of human fetal thymus and spleen lymphocytes by human T-cell leukemia virus type I. Acta Med Okayama 1985;39:155-159
33. Harada S, Koyanagi Y, and Yamamoto N: Infection of HTLV-III/LAV in HTLV-I-carrying cells MT-2 and MT-4 and application in a plaque assay. Science 1985;229:563-566