Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 20, 2013, Pages 8206-8211

  Mike, Laura A ^a   Dutter, Brendan F ^b   Stauff, Devin L ^a   Moore, Jessica L ^b,c   Vitko, Nicholas P ^d   Aranmolate, Olusegun ^a   Kehl Fie, Thomas E ^a   Sullivan, Sarah ^e   Reid, Paul R ^b   DuBois, Jennifer L ^f   Richardson, Anthony R ^d   Caprioli, Richard M ^b,c   Sulikowski, Gary A ^b,c   Skaar, Eric P ^a,b  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VANDERBILT UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF NOTRE DAME   (United States)

^f SRI INTERNATIONAL   (United States)

Author keywords

Glycolysis; Heme oxygenase; High throughput screen (HTS); Two component system (TCS)

Indexed keywords

HEME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL LOAD; BACTERIAL METABOLISM; BACTERIOSTASIS; CONTROLLED STUDY; CORYNEBACTERIUM DIPHTHERIAE; ENZYMATIC DEGRADATION; FERMENTATION; FIRMICUTES; HEME SYNTHESIS; HIGH THROUGHPUT SCREENING; IMMUNOCOMPETENT CELL; LIVER ABSCESS; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS HAEMOLYTICUS; TRANSPOSON;

GLYCOLYSIS; HEME OXYGENASE; HIGH-THROUGHPUT SCREEN (HTS); TWO-COMPONENT SYSTEM (TCS);

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; FERMENTATION; GENE EXPRESSION REGULATION, BACTERIAL; GLYCOLYSIS; HEME; HEME OXYGENASE (DECYCLIZING); INHIBITORY CONCENTRATION 50; LEUKOCYTES; MASS SPECTROMETRY; MICE; MICROSCOPY, ELECTRON, SCANNING; NAPHTHOLS; PHAGOCYTES; PYRAZOLES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

EID: 84877863886     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303674110     Document Type: Article

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