Effects of Pharmacists' Interventions on Appropriateness of Prescribing and Evaluation of the Instruments' (MAI, STOPP and STARTs') Ability to Predict Hospitalization-Analyses from a Randomized Controlled Trial

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Gillespie, Ulrika ^a   Alassaad, Anna ^a   Hammarlund Udenaes, Margareta ^a   Mörlin, Claes ^a   Henrohn, Dan ^a,b   Bertilsson, Maria ^c   Melhus, Håkan ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b MEDICAL PRODUCTS AGENCY   (Sweden)

^c UPPSALA CLINICAL RESEARCH CENTER   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HOSPITAL READMISSION; HOSPITAL UTILIZATION; HOSPITALIZATION; HUMAN; INAPPROPRIATE PRESCRIBING; MAJOR CLINICAL STUDY; MALE; MEDICATION APPROPRIATNESS INDEX; MEDICATION ERROR; PHARMACIST; PRESCRIPTION; RANDOMIZED CONTROLLED TRIAL (TOPIC); SCORING SYSTEM; SCREENING TOOL OF OLDER PERSON PRESCRIPTION; SCREENING TOOL TO ALERT DOCTOR TO RIGHT TREATMENT; CLINICAL PRACTICE; ELDERLY CARE; MEDICATION THERAPY MANAGEMENT; PREVENTION AND CONTROL; RANDOMIZED CONTROLLED TRIAL; STANDARDS; STATISTICS AND NUMERICAL DATA; VERY ELDERLY;

AGED, 80 AND OVER; HEALTH SERVICES FOR THE AGED; HOSPITALIZATION; HUMANS; INAPPROPRIATE PRESCRIBING; MEDICATION ERRORS; MEDICATION THERAPY MANAGEMENT; PHARMACISTS; PHYSICIAN'S PRACTICE PATTERNS;

EID: 84877863132     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0062401     Document Type: Article

References (42)

1. Simonson W, Feinberg JL, (2005) Medication-related problems in the elderly: defining the issues and identifying solutions. Drugs Aging 22: 559-69.
2. Gurwitz JH, Rochon P, (2002) Improving the quality of medication use in elderly patients: a not-so-simple prescription. Arch Intern Med 162: 1670-2.
3. Hanlon JT, Schmader KE, Ruby CM, Weinberger M, (2001) Suboptimal prescribing in older inpatients and outpatients. J Am Geriatr Soc 49: 200-9.
4. Gurwitz JH, Soumerai SB, Avorn J, (1990) Improving medication prescribing and utilization in the nursing home. J Am Geriatr Soc 38: 542-52.
5. Spinewine A, Fialová D, Byrne S, (2012) The role of the pharmacist in optimizing pharmacotherapy in older people. Drugs Aging 29: 495-510.
6. Gillespie U, Alassaad A, Henrohn D, Garmo H, Hammarlund-Udenaes M, et al. (2009) A comprehensive pharmacist intervention to reduce morbidity in patients 80 years or older: a randomized controlled trial. Arch Intern Med 169: 894-900.
7. Schnipper JL, Kirwin JL, Cotugno MC, Wahlstrom SA, Brown BA, et al. (2006) Role of pharmacist counseling in preventing adverse drug events after hospitalization. Arch Intern Med 166: 565-71.
8. Leape LL, Cullen DJ, Clapp MD, Burdick E, Demonaco HJ, et al. (1999) Pharmacist participation on physician rounds and adverse drug events in the intensive care unit. JAMA 282: 267-70.
9. Scullin C, Scott MG, Hogg A, McElnay JC, (2007) An innovative approach to integrated medicines management. J Eval Clin Pract 13: 781-8.
10. Spinewine A, Schmader KE, Barber N, Hughes C, Lapane KL, et al. (2007) Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet 370: 173-84.
11. Pronovost PJ, Nolan T, Zeger S, Miller M, Rubin H, (2004) How can clinicians measure safety and quality in acute care? Lancet 363: 1061-7.
12. Beers MH, Ouslander JG, Rollingher I, Reuben DB, Brooks J, et al. (1991) Explicit criteria for determining inappropriate medication use in nursing home residents. UCLA Division of Geriatric Medicine. Arch Intern Med 151: 1825-32.
13. Beers MH, (1997) Explicit criteria for determining potentially inappropriate medication use by the elderly. An update. Arch Intern 157: 1531-6.
14. Fick DM, Cooper JW, Wade WE, Waller JL, Maclean JR, et al. (2003) Updating the Beers criteria for potentially inappropriate medication use in older adults: results of a US consensus panel of experts. Arch Intern Med 163: 2716-24.
15. American Geriatrics Society (2012) updated Beers Criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 60: 616-31.
16. Lau DT, Kasper JD, Potter DEB, Lyles A, Bennett RG, (2005) Hospitalization and death associated with potentially inappropriate medication prescriptions among elderly nursing home residents. Arch Intern Med 165: 68-74.
17. Ruggiero C, Dell'Aquila G, Gasperini B, Onder G, Lattanzio F, et al. (2010) Potentially inappropriate drug prescriptions and risk of hospitalization among older, Italian, nursing home residents: the ULISSE project. Drugs Aging 27: 747-58.
18. Gallagher PF, Barry PJ, Ryan C, Hartigan I, O'Mahony D, (2008) Inappropriate prescribing in an acutely ill population of elderly patients as determined by Beers' Criteria. Age Ageing 37: 96-101.
19. Pozzi C, Lapi F, Mazzaglia G, Inzitari M, Boncinelli M, et al. (2010) Is suboptimal prescribing a risk factor for poor health outcomes in community-dwelling elders? The ICARe Dicomano study. Pharmacoepidemiol Drug Saf 19: 954-60.
20. Barnett K, McCowan C, Evans JMM, Gillespie ND, Davey PG, et al. (2011) Prevalence and outcomes of use of potentially inappropriate medicines in older people: cohort study stratified by residence in nursing home or in the community. BMJ Qual Saf 20: 275-81.
21. Gallagher P, Ryan C, Byrne S, Kennedy J, O'Mahony D, (2008) STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther 46: 72-83.
22. Gallagher P, Baeyens J-P, Topinkova E, Madlova P, Cherubini A, et al. (2009) Inter-rater reliability of STOPP (Screening Tool of Older Persons' Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment) criteria amongst physicians in six European countries. Age Ageing 38: 603-6.
23. Barry PJ, Gallagher P, Ryan C, O'mahony D, (2007) START (screening tool to alert doctors to the right treatment)-an evidence-based screening tool to detect prescribing omissions in elderly patients. Age Ageing 36: 632-8.
24. Hamilton H, Gallagher P, Ryan C, Byrne S, O'Mahony D, (2011) Potentially inappropriate medications defined by STOPP criteria and the risk of adverse drug events in older hospitalized patients. Arch Intern Med 171: 1013-9.
25. Dalleur O, Spinewine A, Henrard S, Losseau C, Speybroeck N, et al. (2012) Inappropriate prescribing and related hospital admissions in frail older persons according to the STOPP and START criteria. Drugs Aging 29: 829-37.
26. Gallagher PF, O'Connor MN, O'Mahony D, (2011) Prevention of potentially inappropriate prescribing for elderly patients: a randomized controlled trial using STOPP/START criteria. Clin Pharmacol Ther 89: 845-54.
27. Hanlon JT, Schmader KE, Samsa GP, Weinberger M, Uttech KM, et al. (1992) A method for assessing drug therapy appropriateness. J Clin Epidemiol 45: 1045-51.
28. Samsa GP, Hanlon JT, Schmader KE, Weinberger M, Clipp EC, et al. (1994) A summated score for the medication appropriateness index: development and assessment of clinimetric properties including content validity. J Clin Epidemiol 47: 891-6.
29. Hellström LM, Bondesson A, Höglund P, Midlöv P, Holmdahl L, et al. (2011) Impact of the Lund Integrated Medicines Management (LIMM) model on medication appropriateness and drug-related hospital revisits. Eur J Clin Pharmacol 67: 741-52.
30. Spinewine A, Swine C, Dhillon S, Lambert P, Nachega JB, et al. (2007) Effect of a collaborative approach on the quality of prescribing for geriatric inpatients: a randomized, controlled trial. J Am Geriatr Soc 55: 658-65.
31. Hanlon JT, Weinberger M, Samsa GP, Schmader KE, Uttech KM, et al. (1996) A randomized, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy. Am J Med 100: 428-37.
32. Burnett KM, Scott MG, Fleming GF, Clark CM, McElnay JC, et al. (2009) Effects of an integrated medicines management program on medication appropriateness in hospitalized patients. Am J Health Syst Pharm 66: 854-9.
33. Steinman MA, Rosenthal GE, Landefeld CS, Bertenthal D, Sen S, et al. (2007) Conflicts and concordance between measures of medication prescribing quality. Med Care 45: 95-9.
34. Luo R, Scullin C, Mullan AMP, Scott MG, McElnay JC, (2012) Comparison of tools for the assessment of inappropriate prescribing in hospitalized older people. J Eval Clin Pract 18: 1196-202.
35. Patterson SM, Hughes C, Kerse N, Cardwell CR, Bradley MC, (2012) Interventions to improve the appropriate use of polypharmacy for older people. Cochrane Database Syst Rev 2012;5: CD008165.
36. Koch GG, Amara IA, Davis GW, Gillings DB, (1982) A review of some statistical methods for covariance analysis of categorical data. Biometrics 38: 563-95.
37. Stokes M., Davis CG, Koch GG (2000) Categorical data analysis using the SAS® system. Second edition. Cary, NC: SAS Institute Inc. 2000;.
38. Crotty M, Rowett D, Spurling L, Giles LC, Phillips PA, (2004) Does the addition of a pharmacist transition coordinator improve evidence-based medication management and health outcomes in older adults moving from the hospital to a long-term care facility? Results of a randomized, controlled trial. Am J Geriatr Pharmacother 2: 257-64.
39. Gallagher P, O'Mahony D, (2008) STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions): application to acutely ill elderly patients and comparison with Beers' criteria. Age Ageing 37: 673-9.
40. Mainz J, (2003) Developing evidence-based clinical indicators: a state of the art methods primer. Int J Qual Health Care 15 Suppl 1: i5-11.
41. Rubin HR, Pronovost P, Diette GB, (2001) From a process of care to a measure: the development and testing of a quality indicator. Int J Qual Health Care 13: 489-96.
42. Bonnet-Zamponi D, D' Arailh L, Konrat C, Delpierre S, Lieberherr D, et al. (2013) Drug-Related Readmissions to Medical Units of Older Adults Discharged from Acute Geriatric Units: Results of the Optimization of Medication in AGEd Multicenter Randomized Controlled Trial. J Am Geriatr Soc 61: 113-21.