Risk interaction of obesity, insulin resistance and hormone-sensitive lipase promoter polymorphisms (LIPE-60 C > G) in the development of fatty liver

BMC Medical Genetics

Volumn 14, Issue 1, 2013, Pages

  Hsiao, Pi Jung ^a,c   Chen, Zhih Cherg ^b   Hung, Wei Wen ^a   Yang, Yi Hsin Connie ^a,c   Lee, Mei Yueh ^a   Huang, Jee Fu ^a,c   Kuo, Kung Kai ^a,c,d  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Hormone sensitive lipase (HSL); Insulin resistance; Metabolic syndrome; Non alcoholic fatty liver disease (NAFLD)

Indexed keywords

GLUCOSE; HORMONE SENSITIVE LIPASE; INSULIN; TRIACYLGLYCEROL;

ACCURACY; ADIPOSE TISSUE; ADULT; ALCOHOL ABUSE; ARTICLE; BODY MASS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE COURSE; ECHOGRAPHY; GENE SEQUENCE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION;

ADULT; CROSS-SECTIONAL STUDIES; ETHANOL; FATTY LIVER; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE INTOLERANCE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RISK FACTORS; STEROL ESTERASE; TRIGLYCERIDES;

EID: 84877862301     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-14-54     Document Type: Article

References (39)

1. Fan JG, Farrell GC. Epidemiology of non-alcoholic fatty liver disease in China. J Hepatol 2009, 50(1):204-210. 10.1016/j.jhep.2008.10.010, 19014878.
2. Fan JG, Saibara T, Chitturi S, Kim BI, Sung JJ, Chutaputti A. What are the risk factors and settings for non-alcoholic fatty liver disease in Asia-Pacific?. J Gastroenterol Hepatol 2007, 22(6):794-800. 10.1111/j.1440-1746.2007.04952.x, 17498218.
3. Ritchie SA, Connell JM. The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metab Cardiovasc Dis 2007, 17(4):319-326. 10.1016/j.numecd.2006.07.005, 17110092.
4. Larter CZ, Chitturi S, Heydet D, Farrell GC. A fresh look at NASH pathogenesis. Part 1: the metabolic movers. J Gastroenterol Hepatol 2010, 25(4):672-690. 10.1111/j.1440-1746.2010.06253.x, 20492324.
5. Hsiao PJ, Kuo KK, Shin SJ, Yang YH, Lin WY, Yang JF, Chiu CC, Chuang WL, Tsai TR, Yu ML. Significant correlations between severe fatty liver and risk factors for metabolic syndrome. J Gastroenterol Hepatol 2007, 22(12):2118-2123. 10.1111/j.1440-1746.2006.04698.x, 18031368.
6. Wang J, Thornton JC, Russell M, Burastero S, Heymsfield S, Pierson RN. Asians have lower body mass index (BMI) but higher percent body fat than do whites: comparisons of anthropometric measurements. Am J Clin Nutr 1994, 60(1):23-28.
7. Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology 2010, 51(2):679-689. 10.1002/hep.23280, 3575093, 20041406.
8. Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest 2008, 118(3):829-838. 10.1172/JCI34275, 2254980, 18317565.
9. Fernandez-Real JM, Menendez JA, Moreno-Navarrete JM, Bluher M, Vazquez-Martin A, Vazquez MJ, Ortega F, Dieguez C, Fruhbeck G, Ricart W. Extracellular fatty acid synthase: a possible surrogate biomarker of insulin resistance. Diabetes 2010, 59(6):1506-1511. 10.2337/db09-1756, 2874712, 20299470.
10. Dorn C, Riener MO, Kirovski G, Saugspier M, Steib K, Weiss TS, Gabele E, Kristiansen G, Hartmann A, Hellerbrand C. Expression of fatty acid synthase in nonalcoholic fatty liver disease. Int J Clin Exp Pathol 2010, 3(5):505-514. 2897101, 20606731.
11. Carmen GY, Victor SM. Signalling mechanisms regulating lipolysis. Cell Signal 2006, 18(4):401-408. 10.1016/j.cellsig.2005.08.009, 16182514.
12. Jaworski K, Sarkadi-Nagy E, Duncan RE, Ahmadian M, Sul HS. Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue. Am J Physiol Gastrointest Liver Physiol 2007, 293(1):G1-G4. 10.1152/ajpgi.00554.2006, 2887286, 17218471.
13. Avramoglu RK, Basciano H, Adeli K. Lipid and lipoprotein dysregulation in insulin resistant states. Clin Chim Acta 2006, 368(1-2):1-19.
14. Girard J, Lafontan M. Impact of visceral adipose tissue on liver metabolism and insulin resistance. Part II: visceral adipose tissue production and liver metabolism. Diabetes Metab 2008, 34(5):439-445. 10.1016/j.diabet.2008.04.002, 18562233.
15. Jocken JW, Langin D, Smit E, Saris WH, Valle C, Hul GB, Holm C, Arner P, Blaak EE. Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state. J Clin Endocrinol Metab 2007, 92(6):2292-2299. 10.1210/jc.2006-1318, 17356053.
16. Moreno-Navarrete JM, Botas P, Valdes S, Ortega FJ, Delgado E, Vazquez-Martin A, Bassols J, Pardo G, Ricart W, Menendez JA. Val1483Ile in FASN gene is linked to central obesity and insulin sensitivity in adult white men. Obesity (Silver Spring) 2009, 17(9):1755-1761.
17. Talmud PJ, Palmen J, Walker M. Identification of genetic variation in the human hormone-sensitive lipase gene and 5′ sequences: homology of 5' sequences with mouse promoter and identification of potential regulatory elements. Biochem Biophys Res Commun 1998, 252(3):661-668. 10.1006/bbrc.1998.9597, 9837763.
18. Talmud PJ, Palmen J, Luan J, Flavell D, Byrne CD, Waterworth DM, Wareham NJ. Variation in the promoter of the human hormone sensitive lipase gene shows gender specific effects on insulin and lipid levels: results from the Ely study. Biochim Biophys Acta 2001, 1537(3):239-244. 10.1016/S0925-4439(01)00076-X, 11731226.
19. Bugianesi E, McCullough AJ, Marchesini G. Insulin resistance: a metabolic pathway to chronic liver disease. Hepatology 2005, 42(5):987-1000. 10.1002/hep.20920, 16250043.
20. Neuschwander-Tetri BA. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology 2010, 52(2):774-788. 10.1002/hep.23719, 20683968.
21. Gastaldelli A, Harrison SA, Belfort-Aguilar R, Hardies LJ, Balas B, Schenker S, Cusi K. Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis. Hepatology 2009, 50(4):1087-1093. 10.1002/hep.23116, 19670459.
22. Mundi MS, Karpyak MV, Koutsari C, Votruba SB, O'Brien PC, Jensen MD. Body fat distribution, adipocyte size, and metabolic characteristics of nondiabetic adults. J Clin Endocrinol Metab 2010, 95(1):67-73. 10.1210/jc.2009-1353, 2805479, 19890025.
23. Kovacs P, Stumvoll M. Fatty acids and insulin resistance in muscle and liver. Best Pract Res Clin Endocrinol Metab 2005, 19(4):625-635. 10.1016/j.beem.2005.07.003, 16311221.
24. Ferre P, Foufelle F. Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab 2010, 12(Suppl 2):83-92.
25. Bruce KD, Hanson MA. The developmental origins, mechanisms, and implications of metabolic syndrome. J Nutr 2010, 140(3):648-652. 10.3945/jn.109.111179, 20107145.
26. Vanni E, Bugianesi E, Kotronen A, De Minicis S, Yki-Jarvinen H, Svegliati-Baroni G. From the metabolic syndrome to NAFLD or vice versa?. Dig Liver Dis 2010, 42(5):320-330. 10.1016/j.dld.2010.01.016, 20207596.
27. Alkhouri N, Tamimi TA, Yerian L, Lopez R, Zein NN, Feldstein AE. The inflamed liver and atherosclerosis: a link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk. Dig Dis Sci 2010, 55(9):2644-2650. 10.1007/s10620-009-1075-y, 19960252.
28. Kotronen A, Vehkavaara S, Seppala-Lindroos A, Bergholm R, Yki-Jarvinen H. Effect of liver fat on insulin clearance. Am J Physiol Endocrinol Metab 2007, 293(6):E1709-E1715. 10.1152/ajpendo.00444.2007, 17895288.
29. Kotronen A, Juurinen L, Tiikkainen M, Vehkavaara S, Yki-Jarvinen H. Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes. Gastroenterology 2008, 135(1):122-130. 10.1053/j.gastro.2008.03.021, 18474251.
30. Scaglione R, Di Chiara T, Cariello T, Licata G. Visceral obesity and metabolic syndrome: two faces of the same medal?. Intern Emerg Med 2010, 5(2):111-119. 10.1007/s11739-009-0332-6, 19998063.
31. Wasada T, Kasahara T, Wada J, Jimba S, Fujimaki R, Nakagami T, Iwamoto Y. Hepatic steatosis rather than visceral adiposity is more closely associated with insulin resistance in the early stage of obesity. Metabolism 2008, 57(7):980-985. 10.1016/j.metabol.2008.02.015, 18555841.
32. Qi L, Shen H, Larson I, Barnard JR, Schaefer EJ, Ordovas JM. Genetic variation at the hormone sensitive lipase: gender-specific association with plasma lipid and glucose concentrations. Clin Genet 2004, 65(2):93-100. 10.1111/j.0009-9163.2004.00196.x, 14984467.
33. Carlsson E, Johansson LE, Strom K, Hoffstedt J, Groop L, Holm C, Ridderstrale M. The hormone-sensitive lipase C-60G promoter polymorphism is associated with increased waist circumference in normal-weight subjects. Int J Obes (Lond) 2006, 30(9):1442-1448.
34. Garenc C, Vohl MC, Bouchard C, Perusse L. LIPE C-60G influences the effects of physical activity on body fat and plasma lipid concentrations: the quebec family study. Hum Genomics 2009, 3(2):157-168. 10.1186/1479-7364-3-2-157, 3525276, 19164092.
35. Talmud PJ, Palmen J, Nicaud V, Tiret L. Association of the hormone sensitive lipase -60C > G variant with fasting insulin levels in healthy young men. Nutr Metab Cardiovasc Dis 2002, 12(4):173-177.
36. Reid BN, Ables GP, Otlivanchik OA, Schoiswohl G, Zechner R, Blaner WS, Goldberg IJ, Schwabe RF, Chua SC, Huang LS. Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis. J Biol Chem 2008, 283(19):13087-13099. 10.1074/jbc.M800533200, 2442319, 18337240.
37. Lafontan M, Langin D. Lipolysis and lipid mobilization in human adipose tissue. Prog Lipid Res 2009, 48(5):275-297. 10.1016/j.plipres.2009.05.001, 19464318.
38. Lampidonis AD, Stravopodis DJ, Voutsinas GE, Messini-Nikolaki N, Stefos GC, Margaritis LH, Argyrokastritis A, Bizelis I, Rogdakis E. Cloning and functional characterization of the 5' regulatory region of ovine Hormone Sensitive Lipase (HSL) gene. Gene 2008, 427(1-2):65-79.
39. Ling C, Groop L. Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 2009, 58(12):2718-2725. 10.2337/db09-1003, 2780862, 19940235.