Influence of the probiotic Streptococcus salivarius strain M18 on indices of dental health in children: A randomized double-blind, placebo-controlled trial

Journal of Medical Microbiology

Volumn 62, Issue PART6, 2013, Pages 875-884

  Burton, Jeremy P ^a,b   Drummond, Bernadette K ^c   Chilcott, Chris N ^a   Tagg, John R ^a   Thomson, W Murray ^a   Hale, John D F ^a   Wescombe, Philip A ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICARIES AGENT; PLACEBO; PROBIOTIC AGENT;

ARTICLE; BACTERIAL COLONIZATION; BACTERIAL COUNT; BETA HEMOLYTIC STREPTOCOCCUS; CANDIDA; CELL CULTURE; CHILD; CONTROLLED STUDY; DENTAL CARIES; DENTAL HEALTH; DOUBLE BLIND PROCEDURE; DRUG SAFETY; FEMALE; HUMAN; LACTOBACILLUS; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PATIENT COMPLIANCE; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SALIVA; SCHOOL CHILD; STREPTOCOCCUS MUTANS; STREPTOCOCCUS SALIVARIUS; TOOTH PLAQUE; UNSPECIFIED SIDE EFFECT;

CHILD; CHILD, PRESCHOOL; COLONY COUNT, MICROBIAL; DENTAL CARIES; DENTAL PLAQUE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; LACTOBACILLUS; MALE; MOUTH; PROBIOTICS; SALIVA; STREPTOCOCCUS; STREPTOCOCCUS MUTANS; TREATMENT OUTCOME; VIRIDANS STREPTOCOCCI;

EID: 84877861247     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/jmm.0.056663-0     Document Type: Article

References (37)

1. Adam, E., Jindal, M., Seney, S., Summers, K., Hamilton, D. W., Hatibovic-Kofman, S. & Cadieux, P. A. (2011). Streptococcus salivarius K12 and M18 probiotics reduce periodontal pathogen-induced inflammation. In IADR/AADR/CADR 89th General Session and Exhibition, 16-19 March 2011, San Diego, CA, USA. Paper no. 150126.
2. Bagramian, R. A., Garcia-Godoy, F. & Volpe, A. R. (2009). The global increase in dental caries. A pending public health crisis. Am J Dent 22, 3-8.
3. Broadbent, J. M., Thomson, W. M., Boyens, J. V. & Poulton, R. (2011). Dental plaque and oral health during the first 32 years of life. J Am Dent Assoc 142, 415-426.
4. Burton, J. P., Chilcott, C. N., Moore, C. J., Speiser, G. & Tagg, J. R. (2006a). A preliminary study of the effect of probiotic Streptococcus salivarius K12 on oral malodour parameters. J Appl Microbiol 100, 754-764.
5. Burton, J. P., Wescombe, P. A., Moore, C. J., Chilcott, C. N. & Tagg, J. R. (2006b). Safety assessment of the oral cavity probiotic Streptococcus salivarius K12. Appl Environ Microbiol 72, 3050-3053.
6. Burton, J. P., Wescombe, P. A., Cadieux, P. A. & Tagg, J. R. (2011a). Beneficial microbes for the oral cavity: time to harness the oral streptococci? Benef Microbes 2, 93-101.
7. Burton, J. P., Cowley, S., Simon, R. R., McKinney, J., Wescombe, P. A. & Tagg, J. R. (2011b). Evaluation of safety and human tolerance of the oral probiotic Streptococcus salivarius K12: a randomized, placebocontrolled, double-blind study. Food Chem Toxicol 49, 2356-2364.
8. Caglar, E., Sandalli, N., Twetman, S., Kavaloglu, S., Ergeneli, S. & Selvi, S. (2005). Effect of yogurt with Bifidobacterium DN-173 010 on salivary mutans streptococci and lactobacilli in young adults. Acta Odontol Scand 63, 317-320.
9. Chen, Y. Y., Clancy, K. A. & Burne, R. A. (1996). Streptococcus salivarius urease: genetic and biochemical characterization and expression in a dental plaque streptococcus. Infect Immun 64, 585-592.
10. Chilcott, C. N. & Tagg, J. R. (2007). Antimicrobial composition. US Patent 7226590.
11. Dierksen, K. P. & Tagg, J. (2000). The influence of indigenous bacteriocin-producing Streptococcus salivarius on the acquisition of Streptococcus pyogenes by primary school children in Dunedin, New Zealand. In Streptococci and Streptococcal Diseases Entering the New Millenium, pp. 81-85. Edited by D. R. Martin & J. R. Tagg. Auckland: Securacopy.
12. Dierksen, K. P., Ragland, N. L. & Tagg, J. R. (2000). A new alkaline pH-adjusted medium enhances detection of β-hemolytic streptococci by minimizing bacterial interference due to Streptococcus salivarius. J Clin Microbiol 38, 643-650.
13. Fisher, M. A., Borgnakke, W. S. & Taylor, G. W. (2010). Periodontal disease as a risk marker in coronary heart disease and chronic kidney disease. Curr Opin Nephrol Hypertens 19, 519-526.
14. Greene, J. C. & Vermillion, J. R. (1964). The simplified oral hygiene index. J Am Dent Assoc 68, 7-13.
15. Guglielmetti, S., Taverniti, V., Minuzzo, M., Arioli, S., Stuknyte, M., Karp, M. & Mora, D. (2010). Oral bacteria as potential probiotics for the pharyngeal mucosa. Appl Environ Microbiol 76, 3948-3958.
16. Heng, N. C., Haji-Ishak, N. S., Kalyan, A., Wong, A. Y., Lovric, M., Bridson, J. M., Artamonova, J., Stanton, J. A., Wescombe, P. A. & other authors (2011). Genome sequence of the bacteriocinproducing oral probiotic Streptococcus salivarius strain M18. J Bacteriol 193, 6402-6403.
17. Hillman, J. D., Dzuback, A. L. & Andrews, S. W. (1987). Colonization of the human oral cavity by a Streptococcus mutans mutant producing increased bacteriocin. J Dent Res 66, 1092-1094.
18. Hillman, J. D., Duncan, M. J. & Stashenko, K. P. (1990). Cloning and expression of the gene encoding the fructose-1,6-diphosphatedependent L-(+)-lactate dehydrogenase of Streptococcus mutans. Infect Immun 58, 1290-1295.
19. Hillman, J. D., Novák, J., Sagura, E., Gutierrez, J. A., Brooks, T. A., Crowley, P. J., Hess, M., Azizi, A., Leung, K. & other authors (1998). Genetic and biochemical analysis of mutacin 1140, a lantibiotic from Streptococcus mutans. Infect Immun 66, 2743-2749.
20. Horz, H. P., Meinelt, A., Houben, B. & Conrads, G. (2007). Distribution and persistence of probiotic Streptococcus salivarius K12 in the human oral cavity as determined by real-time quantitative polymerase chain reaction. Oral Microbiol Immunol 22, 126-130.
21. Kanasi, E., Dewhirst, F. E., Chalmers, N. I., Kent, R., Jr, Moore, A., Hughes, C. V., Pradhan, N., Loo, C. Y. & Tanner, A. C. (2010). Clonal analysis of the microbiota of severe early childhood caries. Caries Res 44, 485-497.
22. Li, Y. H., Chen, Y. Y. & Burne, R. A. (2000). Regulation of urease gene expression by Streptococcus salivarius growing in biofilms. Environ Microbiol 2, 169-177.
23. Loe, H. & Silness, J. (1963). Periodontal disease in pregnancy. I. Prevalence and severity. Acta Odontol Scand 21, 533-551.
24. Marsh, P. D. (2003). Are dental diseases examples of ecological catastrophes? Microbiology 149, 279-294.
25. Nascimento, M. M., Gordan, V. V., Garvan, C. W., Browngardt, C. M. & Burne, R. A. (2009). Correlations of oral bacterial arginine and urea catabolism with caries experience. Oral Microbiol Immunol 24, 89-95.
26. Näse, L., Hatakka, K., Savilahti, E., Saxelin, M., Pönkä, A., Poussa, T., Korpela, R. & Meurman, J. H. (2001). Effect of long-term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries Res 35, 412-420.
27. Ohnishi, Y., Kubo, S., Ono, Y., Nozaki, M., Gonda, Y., Okano, H., Matsuya, T., Matsushiro, A. & Morita, T. (1995). Cloning and sequencing of the gene coding for dextranase from Streptococcus salivarius. Gene 156, 93-96.
28. Seymour, G. J. & Gemmell, E. (2001). Cytokines in periodontal disease: where to from here? Acta Odontol Scand 59, 167-173.
29. Tagg, J. R. & Bannister, L. V. (1979). "Fingerprinting" β-haemolytic streptococci by their production of and sensitivity to bacteriocine-like inhibitors. J Med Microbiol 12, 397-411.
30. Tanzer, J. M., Kurasz, A. B. & Clive, J. (1985a). Inhibition of ecological emergence of mutans streptococci naturally transmitted between rats and consequent caries inhibition by Streptococcus salivarius TOVE-R infection. Infect Immun 49, 76-83.
31. Tanzer, J. M., Kurasz, A. B. & Clive, J. (1985b). Competitive displacement of mutans streptococci and inhibition of tooth decay by Streptococcus salivarius TOVE-R. Infect Immun 48, 44-50.
32. Teughels, W., Newman, M. G., Coucke, W., Haffajee, A. D., Van Der Mei, H. C., Haake, S. K., Schepers, E., Cassiman, J. J., Van Eldere, J. & other authors (2007). Guiding periodontal pocket recolonization: a proof of concept. J Dent Res 86, 1078-1082.
33. Van Palenstein Helderman, W. H., Ijsseldijk, M. & Huis in't Veld, J. H. (1983). A selective medium for the two major subgroups of the bacterium Streptococcus mutans isolated from human dental plaque and saliva. Arch Oral Biol 28, 599-603.
34. Wescombe, P. A., Burton, J. P., Cadieux, P. A., Klesse, N. A., Hyink, O., Heng, N. C., Chilcott, C. N., Reid, G. & Tagg, J. R. (2006). Megaplasmids encode differing combinations of lantibiotics in Streptococcus salivarius. Antonie van Leeuwenhoek 90, 269-280.
35. Wescombe, P. A., Heng, N. C., Burton, J. P., Chilcott, C. N. & Tagg, J. R. (2009). Streptococcal bacteriocins and the case for Streptococcus salivarius as model oral probiotics. Future Microbiol 4, 819- 835.
36. Wescombe, P. A., Upton, M., Renault, P., Wirawan, R. E., Power, D., Burton, J. P., Chilcott, C. N. & Tagg, J. R. (2011). Salivaricin 9, a new lantibiotic produced by Streptococcus salivarius. Microbiology 157, 1290-1299.
37. Zarco, M. F., Vess, T. J. & Ginsburg, G. S. (2012). The oral microbiome in health and disease and the potential impact on personalized dental medicine. Oral Dis 18, 109-120.