18β-Glycyrrhetinic acid from licorice root impairs dendritic cells maturation and Th1 immune responses

Immunopharmacology and Immunotoxicology

Volumn 35, Issue 3, 2013, Pages 329-335

  Kim, Mi Eun ^a   Kim, Hyung Keun ^b   Kim, Dong Hwan ^a   Yoon, Ju Hwa ^a   Lee, Jun Sik ^a  

^a Chosun University   (South Korea)

^b Chonnam National University Medical School   (South Korea)

Author keywords

18 Glycyrrhetinic acid; Cytokines; Dendritic cells; T cells

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; GLYCYRRHETINIC ACID; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 4; LIPOPOLYSACCHARIDE;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CD4+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; FLOW CYTOMETRY; GLYCYRRHIZA; GROWTH INHIBITION; IMMUNE RESPONSE; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TH1 CELL; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; COCULTURE TECHNIQUES; CYTOKINES; DENDRITIC CELLS; ENDOCYTOSIS; FLOW CYTOMETRY; GLYCYRRHETINIC ACID; GLYCYRRHIZA; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PLANT ROOTS; TH1 CELLS;

EID: 84877859369     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2013.768636     Document Type: Article

References (22)

1. Lee HJ, Jeong YI, Lee TH, et al. Rosmarinic acid inhibits indoleamine 2,3-dioxygenase expression in murine dendritic cells. Biochem Pharmacol 2007;73:1412-21
2. Sawant A, Hensel JA, Chanda D, et al. Depletion of plasmacytoid dendritic cells inhibits tumor growth and prevents bone metastasis of breast cancer cells. J Immunol 2012;189:4258-65
3. Carrion J, Scisci E, Miles B, et al. Microbial carriage state of peripheral blood dendritic cells (DCs) in chronic periodontitis influences DC differentiation, atherogenic potential. J Immunol 2012;189:3178-87
4. Joshi N, Duhan V, Lingwal N, et al. Adjuvant properties of thermal component of hyperthermia enhanced transdermal immunization: effect on dendritic cells. PLoS One 2012;7:e32067-e32078
5. Mattsson J, Yrlid U, Stensson A, et al. Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant. J Immunol 2011;187:3641-52
6. Li L, Kim S, Herndon JM, et al. Cross-dressed CD8alphaθ/ CD103θ dendritic cells prime CD8θ T cells following vaccination. Proc Natl Acad Sci USA 2012;109:12716-21
7. Rosenits K, Keppler SJ, Vucikuja S, Aichele P. T cells acquire cell surface determinants of APC via in vivo trogocytosis during viral infections. Eur J Immunol 2010;40:3450-7
8. Reichardt P, Dornbach B, Gunzer M. APC, T cells, and the immune synapse. Curr Top Microbiol Immunol 2010;340:229-49
9. Wetzel SA, Parker DC. MHC transfer from APC to T cells following antigen recognition. Crit Rev Immunol 2006;26:1-21
10. Vlad G, Cortesini R, Suciu-Foca N. License to heal: bidirectional interaction of antigen-specific regulatory T cells and tolerogenic APC. J Immunol 2005;174:5907-14
11. Lee JS, Kim SG, Kim HK. Silibinin polarizes Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells. J Cell Physiol 2007;210:385-97
12. Stenger EO, Turnquist HR, Mapara MY, Thomson AW. Dendritic cells and regulation of graft-versus-host disease and graft-versusleukemia activity. Blood 2012;119:5088-103
13. Zheng D, Cao Q, Lee VW, et al. Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. Kidney Int 2012;81:892-902
14. Rutella S, Locatelli F. Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease. World J Gastroenterol 2011; 17:3761-75
15. Lee JS, Jung ID, Jeong YI, et al. D-pinitol inhibits Th1 polarization via the suppression of dendritic cells. Int Immunopharmacol 2007;7:791-804
16. Kim SI, Jeong YI, Jung ID, et al. p-Coumaric acid inhibits indoleamine 2,3-dioxygenase expression in murine dendritic cells. Int Immunopharmacol 2007;7:805-15
17. Asl MN, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res 2008;22:709-24
18. Kuang P, Zhao W, Su W, et al. 18beta-Glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing hepatic stellate cell-mediated immunosuppression in mice. Int J Cancer 2012; Sep 18 [Epub adead of print]
19. Jeong YJ, Hong SW, Kim JH, et al. Vitamin C-treated murine bone marrow-derived dendritic cells preferentially drive naive T cells into Th1 cells by increased IL-12 secretions. Cell Immunol 2011;266:192-9
20. Lipscomb MW, Chen L, Taylor JL, et al. Ectopic T-bet expression licenses dendritic cells for IL-12-independent priming of type 1 T cells in vitro. J Immunol 2009;183:7250-8
21. Soares H, Waechter H, Glaichenhaus N, et al. A subset of dendritic cells induces CD4θ T cells to produce IFN-gamma by an IL-12- independent but CD70-dependent mechanism in vivo. J Exp Med 2007;204:1095-106
22. Miro F, Nobile C, Blanchard N, et al. T cell-dependent activation of dendritic cells requires IL-12 and IFN-gamma signaling in T cells. J Immunol 2006;177:3625-34