Analysis of functional pathways altered after mild traumatic brain injury

Journal of Neurotrauma

Volumn 30, Issue 9, 2013, Pages 752-764

  Redell, John B ^a   Moore, Anthony N ^a   Grill, Raymond J ^a   Johnson, Daniel ^a   Zhao, Jing ^a   Liu, Yin ^a   Dash, Pramod K ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Bioinformatics; GFAP; IL 1 ; MIP 1 ; Neuroinflammation; UCHL1

Indexed keywords

CHEMOKINE; CXCL1 CHEMOKINE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOINFORMATICS; BRAIN BLOOD VESSEL; BRAIN CORTEX; BRAIN FUNCTION; COMPARATIVE STUDY; CONTROLLED STUDY; FLUID PERCUSSION INJURY; GENE EXPRESSION; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MICROARRAY ANALYSIS; MICROGLIA; MILD CONTROLLED CORTICAL IMPACT; NONHUMAN; PROTEIN LOCALIZATION; RAT; RNA PROBE; STRESS; TRAUMATIC BRAIN INJURY;

ANIMALS; BLOTTING, WESTERN; BRAIN; BRAIN CONCUSSION; CHEMOKINES; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TRANSCRIPTOME;

EID: 84877848201     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2012.2437     Document Type: Article

References (58)

1. Jager, T.E., Weiss, H.B., Coben, J.H., and Pepe, P.E. (2000). Traumatic brain injuries evaluated in U.S. emergency departments, 1992-1994. Acad. Emerg. Med. 7, 134-140. (Pubitemid 30084644)
2. Sosin, D.M., Sniezek, J.E., and Thurman, D.J. (1996). Incidence of mild and moderate brain injury in the United States, 1991. Brain Inj. 10, 47-54. (Pubitemid 26093550)
3. Hoge, C.W., McGurk, D., Thomas, J.L., Cox, A.L., Engel, C.C., and Castro, C.A. (2008). Mild traumatic brain injury in U.S. soldiers returning from Iraq. N. Engl. J. Med. 358, 453-463. (Pubitemid 351185801)
4. Schneiderman, A.I., Braver, E.R., and Kang, H.K. (2008). Understanding sequelae of injury mechanisms and mild traumatic brain injury incurred during the conflicts in Iraq and Afghanistan: Persistent postconcussive symptoms and posttraumatic stress disorder. Am. J. Epidemiol. 167, 1446-1452.
5. Bryant, R.A., and Harvey, A.G. (1999). The influence of traumatic brain injury on acute stress disorder and post-traumatic stress disorder following motor vehicle accidents. Brain Inj. 13, 15-22. (Pubitemid 29043315)
6. Creamer, M., O'Donnell, M.L., and Pattison, P. (2005). Amnesia, traumatic brain injury, and posttraumatic stress disorder: A methodological inquiry. Behav. Res. Ther. 43, 1383-1389. (Pubitemid 41116280)
7. d'Hemecourt, P. (2011). Subacute symptoms of sports-related concussion: Outpatient management and return to play. Clin. Sports Med. 30, 63-72, viii.
8. Ruff, R.M. (2011). Mild traumatic brain injury and neural recovery: Rethinking the debate. NeuroRehabilitation 28, 167-180.
9. Sherer, M., Yablon, S.A., and Nakase-Richardson, R. (2009). Patterns of recovery of posttraumatic confusional state in neurorehabilitation admissions after traumatic brain injury. Arch. Phys. Med. Rehabil. 90, 1749-1754.
10. Alves, W., Macciocchi, S.N., and Barth, J.T. (1993). Postconcussive symptoms after uncomplicated mild head injury. J. Head Trauma Rehabil. 8, 48-59. (Pubitemid 23270994)
11. Carroll, L.J., Cassidy, J.D., Peloso, P.M., Borg, J., von, Holst, H., Holm, L., Paniak, C., and Pepin, M. (2004). Prognosis for mild traumatic brain injury: Results of the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury. J. Rehabil. Med. Suppl. 43, 84-105. (Pubitemid 38268224)
12. Hessen, E., Nestvold, K., and Anderson, V. (2007). Neuropsychological function 23 years after mild traumatic brain injury: A comparison of outcome after paediatric and adult head injuries. Brain Inj. 21, 963-979. (Pubitemid 47338062)
13. Holm, L., Cassidy, J.D., Carroll, L.J., and Borg, J. (2005). Summary of the WHO Collaborating Centre for Neurotrauma Task Force on Mild Traumatic Brain Injury. J. Rehabil. Med. 37, 137-141. (Pubitemid 40775151)
14. Rimel, R.W., Giordani, B., Barth, J.T., Boll, T.J., and Jane, J.A. (1981). Disability caused by minor head injury. Neurosurgery 9, 221-228. (Pubitemid 11061166)
15. Vanderploeg, R.D., Curtiss, G., Luis, C.A., and Salazar, A.M. (2007). Long-term morbidities following self-reported mild traumatic brain injury. J. Clin. Exp. Neuropsychol. 29, 585-598. (Pubitemid 47254604)
16. Andriessen, T.M., Jacobs, B., and Vos, P.E. (2010). Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury. J. Cell Mol. Med. 14, 2381-2392.
17. Farkas, O., and Povlishock, J.T. (2007). Cellular and subcellular change evoked by diffuse traumatic brain injury: A complex web of change extending far beyond focal damage. Prog. Brain Res. 161, 43-59. (Pubitemid 47018312)
18. Gennarelli, T.A. (1996). The spectrum of traumatic axonal injury. Neuropathol. Appl. Neurobiol. 22, 509-513. (Pubitemid 27023364)
19. Morganti-Kossmann, M.C., Yan, E., and Bye, N (2010). Animal models of traumatic brain injury: Is there an optimal model to reproduce human brain injury in the laboratory? Injury 41, S10- S13.
20. Saatman, K.E., Duhaime, A.C., Bullock, R., Maas, A.I., Valadka, A., and Manley, G.T. (2008). Classification of traumatic brain injury for targeted therapies. J. Neurotrauma 25, 719-738.
21. Smith, D.H., Chen, X.H., Xu, B.N., McIntosh, T.K., Gennarelli, T.A., and Meaney, D.F. (1997). Characterization of diffuse axonal pathology and selective hippocampal damage following inertial brain trauma in the pig. J. Neuropathol. Exp. Neurol. 56, 822-834. (Pubitemid 27280193)
22. Gurkoff, G.G., Giza, C.C., and Hovda, D.A. (2006). Lateral fluid percussion injury in the developing rat causes an acute, mild behavioral dysfunction in the absence of significant cell death. Brain Res. 1077, 24-36.
23. Schultz, B.A., Cifu, D.X., McNamee, S., Nichols, M., and Carne, W. (2011). Assessment and treatment of common persistent sequelae following blast induced mild traumatic brain injury. NeuroRehabilitation 28, 309-320.
24. Yu, S., Kaneko, Y., Bae, E., Stahl, C.E., Wang, Y., van, Loveren, H., Sanberg, P.R., and Borlongan, C.V. (2009). Severity of controlled cortical impact traumatic brain injury in rats and mice dictates degree of behavioral deficits. Brain Res. 1287, 157-163.
25. Dixon, C.E., Lyeth, B.G., Povlishock, J.T., Findling, R.L., Hamm, R.J., Marmarou, A., Young, H.F., and Hayes, R.L. (1987). A fluid percussion model of experimental brain injury in the rat. J. Neurosurg. 67, 110-119. (Pubitemid 17085024)
26. Kelley, B.J., Farkas, O., Lifshitz, J., and Povlishock, J.T. (2006). Traumatic axonal injury in the perisomatic domain triggers ultrarapid secondary axotomy and Wallerian degeneration. Exp. Neurol. 198, 350-360.
27. Hicks, R.R., Martin, V.B., Zhang, L., and Seroogy, K.B. (1999). Mild experimental brain injury differentially alters the expression of neurotrophin and neurotrophin receptor mRNAs in the hippocampus. Exp. Neurol. 160, 469-478.
28. Phillips, L.L., and Belardo, E.T. (1992). Expression of c-fos in the hippocampus following mild and moderate fluid percussion brain injury. J Neurotrauma 9, 323-333. (Pubitemid 23031057)
29. Raghupathi, R., and McIntosh, T.K. (1996). Regionally and temporally distinct patterns of induction of c-fos, c-jun, and junB mRNAs following experimental brain injury in the rat. Brain Res. Mol. Brain Res. 37, 134-144. (Pubitemid 26147983)
30. Dixon, C.E., Clifton, G.L., Lighthall, J.W., Yaghmai, A.A., and Hayes, R.L. (1991). A controlled cortical impact model of traumatic brain injury in the rat. J. Neurosci. Methods 39, 253-262.
31. Redell, J.B., Zhao, J., and Dash, P.K. (2011). Altered expression of miRNA-21 and its targets in the hippocampus after traumatic brain injury. J. Neurosci. Res. 89, 212-221.
32. Cherian, L., Robertson, C.S., Contant, C.F., Jr., and Bryan, R.M., Jr. (1994). Lateral cortical impact injury in rats: Cerebrovascular effects of varying depth of cortical deformation and impact velocity. J. Neurotrauma 11, 573-585. (Pubitemid 24347279)
33. Colgan, N.C., Cronin, M.M., Gobbo, O.L., O'Mara, S.M., O'Connor, W.T., and Gilchrist, M.D. (2010). Quantitative MRI analysis of brain volume changes due to controlled cortical impact. J. Neurotrauma 27, 1265-1274.
34. Golding, E.M., Robertson, C.S., Fitch, J.C., Goodman, J.C., and Bryan, R.M., Jr. (2003). Segmental vascular resistance after mild controlled cortical impact injury in the rat. J. Cereb. Blood Flow Metab. 23, 210-218. (Pubitemid 36188459)
35. Benjamini, Y., and Hochberg, Y. (1995). Controlling the false discovery rate: A practical and powerful approach to multiple testing. J. R. Stat. Soc. Ser. B 57, 289-300.
36. Berardini, T.Z., Li, D., Huala, E., Bridges, S., Burgess, S., McCarthy, F., and Gene Ontology Consortium. (2010). The Gene Ontology in 2010: Extensions and refinements. Nucleic Acids Res. 38, D331- D335.
37. Carbon, S., Ireland, A., Mungall, C.J., Shu, S., Marshall, B., and Lewis, S. (2009). AmiGO: Online access to ontology and annotation data. Bioinformatics 25, 288-289.
38. Hallam, T.M., Floyd, C.L., Folkerts, M.M., Lee, L.L., Gong, Q.Z., Lyeth, B.G., Muizelaar, J.P., and Berman, R.F. (2004). Comparison of behavioral deficits and acute neuronal degeneration in rat lateral fluid percussion and weight-drop brain injury models. J. Neurotrauma 21, 521-539. (Pubitemid 38656750)
39. Hamm, R.J. (2001). Neurobehavioral assessment of outcome following traumatic brain injury in rats: An evaluation of selected measures. J. Neurotrauma 18, 1207-1216. (Pubitemid 33062544)
40. Morehead, M., Bartus, R.T., Dean, R.L., Miotke, J.A., Murphy, S., Sall, J., and Goldman, H. (1994). Histopathologic consequences of moderate concussion in an animal model: Correlations with duration of unconsciousness. J. Neurotrauma 11, 657-667.
41. Spain, A., Daumas, S., Lifshitz, J., Rhodes, J., Andrews, P.J., Horsburgh, K., and Fowler, J.H. (2010). Mild fluid percussion injury in mice produces evolving selective axonal pathology and cognitive deficits relevant to human brain injury. J Neurotrauma 27, 1429-1438.
42. Helmy, A., Carpenter, K.L., Menon, D.K., Pickard, J.D., and Hutchinson, P.J. (2011). The cytokine response to human traumatic brain injury: Temporal profiles and evidence for cerebral parenchymal production. J. Cereb. Blood Flow Metab. 31, 658-670.
43. Ziebell, J.M., and Morganti-Kossmann, M.C. (2010). Involvement of pro- and anti-inflammatory cytokines and chemokines in the pathophysiology of traumatic brain injury. Neurotherapeutics 7, 22-30.
44. Giulian, D., Baker, T.J., Shih, L.C., and Lachman, L.B. (1986). Interleukin 1 of the central nervous system is produced by ameboid microglia. J. Exp. Med. 164, 594-604. (Pubitemid 16050703)
45. Zhang, W., Smith, C., Howlett, C., and Stanimirovic, D. (2000). Inflammatory activation of human brain endothelial cells by hypoxic astrocytes in vitro is mediated by IL-1beta. J. Cereb. Blood Flow Metab. 20, 967-978. (Pubitemid 30413680)
46. Chui, R. and Dorovini-Zis, K. (2010). Regulation of CCL2 and CCL3 expression in human brain endothelial cells by cytokines and lipopolysaccharide. J. Neuroinflammation 7, 1.
47. Lu, J., Goh, S.J., Tng, P.Y., Deng, Y.Y., Ling, E.A., and Moochhala, S. (2009). Systemic inflammatory response following acute traumatic brain injury. Front Biosci. 14, 3795-3813.
48. Kinoshita, K., Chatzipanteli, K., Vitarbo, E., Truettner, J.S., Alonso, O.F., and Dietrich, W.D. (2002). Interleukin-1beta messenger ribonucleic acid and protein levels after fluid-percussion brain injury in rats: Importance of injury severity and brain temperature. Neurosurgery 51, 195-203. (Pubitemid 36331114)
49. Rothwell, N. (2003). Interleukin-1 and neuronal injury: Mechanisms, modification, and therapeutic potential. Brain Behav. Immun. 17, 152-157. (Pubitemid 36434364)
50. Israelsson, C., Bengtsson, H., Kylberg, A., Kullander, K., Lewen, A., Hillered, L., and Ebendal, T. (2008). Distinct cellular patterns of upregulated chemokine expression supporting a prominent inflammatory role in traumatic brain injury. J. Neurotrauma 25, 959-974.
51. Israelsson, C., Wang, Y., Kylberg, A., Pick, C.G., Hoffer, B.J., and Ebendal, T. (2009). Closed head injury in a mouse model results in molecular changes indicating inflammatory responses. J. Neurotrauma 26, 1307-1314.
52. Morganti-Kossmann, M.C., Satgunaseelan, L., Bye, N., and Kossmann, T. (2007). Modulation of immune response by head injury. Injury 38, 1392-1400. (Pubitemid 350192405)
53. Rall, J.M., Matzilevich, D.A., and Dash, P.K. (2003). Comparative analysis of mRNA levels in the frontal cortex and the hippocampus in the basal state and in response to experimental brain injury. Neuropathol. Appl. Neurobiol. 29, 118-131. (Pubitemid 36408330)
54. Dash, P.K., Zhao, J., Hergenroeder, G., and Moore, A.N. (2010). Biomarkers for the diagnosis, prognosis, and evaluation of treatment efficacy for traumatic brain injury. Neurotherapeutics 7, 100-114.
55. Mondello, S., Jeromin, A., Buki, A., Bullock, R., Czeiter, E., Kovacs, N., Barzo, P., Schmid, K., Tortella, F., Wang, K.K., and Hayes, R.L. (2012). Glial neuronal ratio: A novel index for differentiating injury type in patients with severe traumatic brain injury. J. Neurotrauma 29, 1096-1104.
56. Kane, M.J., Angoa-Perez, M., Briggs, D.I., Viano, D.C., Kreipke, C.W., and Kuhn, D.M. (2012). A mouse model of human repetitive mild traumatic brain injury. J. Neurosci. Methods 203, 41-49.
57. Metting, Z., Wilczak, N., Rodiger, L.A., Schaaf, J.M., and van der Naalt, J. (2012). GFAP and S100B in the acute phase of mild traumatic brain injury. Neurology 78, 1428-1433.
58. Berger, R.P., Hayes, R.L., Richichi, R., Beers, S.R., and Wang, K.K. (2012). Serum concentrations of ubiquitin C-terminal hydrolase-L1 and alphaII-spectrin breakdown product 145 kDa correlate with outcome after pediatric TBI. J. Neurotrauma 29, 162-167.