Overexpressions of microRNA-9 and microRNA-200c in human breast cancers are associated with lymph node metastasis

Cancer Biotherapy and Radiopharmaceuticals

Volumn 28, Issue 4, 2013, Pages 283-288

  Wang, Jincai ^a   Zhao, Hong ^a   Tang, Dabei ^a   Wu, Jin ^a   Yao, Guodong ^a   Zhang, Qingyuan ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Breast cancer; E cadherin; Metastasis; microRNA 200c; microRNA 9

Indexed keywords

ESTROGEN RECEPTOR; MICRORNA 200C; MICRORNA 9; PROGESTERONE RECEPTOR; UVOMORULIN; CADHERIN; MICRORNA; MIRN200 MICRORNA, HUMAN; MIRN92 MICRORNA, HUMAN; RNA;

ADULT; ARTICLE; BREAST CANCER; CANCER PATIENT; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BREAST TUMOR; CHEMISTRY; GENE EXPRESSION; GENETICS; METABOLISM; MIDDLE AGED; PAGET NIPPLE DISEASE; PATHOLOGY; SECONDARY;

BREAST NEOPLASMS; CADHERINS; CARCINOMA, DUCTAL, BREAST; FEMALE; GENE EXPRESSION; HUMANS; LYMPHATIC METASTASIS; MICRORNAS; MIDDLE AGED; RNA, NEOPLASM;

EID: 84877844447     PISSN: 10849785     EISSN: 15578852     Source Type: Journal    
DOI: 10.1089/cbr.2012.1293     Document Type: Article

References (20)

1. Jemal A, Bray F, Center M. M, et al. Global cancer statistics. CA Cancer J Clin 2011;61:69.
2. Vincent-Salomon A, Thiery JP. Host microenvironment in breast cancer development: Epithelial-mesenchymal transition in breast cancer development. Breast Cancer Res 2003;5:101.
3. Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005;17:548.
4. Kowalski PJ, Rubin MA, Kleer CG. E-cadherin expression in primary carcinomas of the breast and its distant metastases. Breast Cancer Res 2003;5: R217.
5. Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 2009;10:704.
6. Huang Q, Gumireddy K, Schrier M, et al. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat Cell Biol 2008;10:202.
7. Ma L, Young J, Prabhala H, et al. MiR-9, a MYC/MYCNactivated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010;12:247.
8. Hurteau GJ, Carlson JA, Roos E, et al. Stable expression of miR-200c alone is sufficient to regulate TCF8 (ZEB1) and restore E-cadherin expression. Cell Cycle 2009;8:2064.
9. Bendoraite A, Knouf EC, Garg KS, et al. Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: Evidence supporting a mesothelial-Toepithelial transition. Gynecol Oncol 2010;116:117.
10. Lee JW, Choi CH, Choi JJ, et al. Altered MicroRNA expression in cervical carcinomas. Clin Cancer Res 2008;14:2535.
11. Mueller DW, Rehli M, Bosserhoff AK. miRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanoma. J Invest Dermatol 2009;129:1740.
12. Ma L, Weinberg RA. Micromanagers of malignancy: Role of microRNAs inregulatingmetastasis. TrendsGenet2008;24:448.
13. Onder TT, Gupta PB, Mani SA, et al. Loss of E-Cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res 2008;68:3645.
14. Iorio MV, Ferracin M, Liu CG, et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res 2005;65:7065.
15. Park SM, Gaur AB, Lengyel E, et al. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008;22:894.
16. Hurteau GJ, Carlson JA, Spivack SD, et al. Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of Ecadherin. Cancer Res 2007;67:7972.
17. Cochrane DR, Spoelstra NS, Howe EN, et al. MicroRNA-200c mitigates invasiveness and restores sensitivity to microtubule-Targeting chemotherapeutic agents. Mol Cancer Ther 2009;8:1055.
18. Dykxhoorn DM, Wu Y, Xie H, et al. miR-200 enhances mouse breast cancer cell colonization to form distant metastases. PLoS One 2009;4:e7181.
19. Bockmeyer CL, Christgen M, Muller M, et al. MicroRNA profiles of healthy basal and luminal mammary epithelial cells are distinct and reflected in different breast cancer subtypes. Breast Cancer Res Treat 2011;130:35.
20. Baffa R, Fassan M, Volinia S, et al. MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol 2009;219:214.