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Volumn 8, Issue 5, 2013, Pages

FGFR4 Role in Epithelial-Mesenchymal Transition and Its Therapeutic Value in Colorectal Cancer

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 4; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN TYROSINE KINASE; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN;

EID: 84877831896     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063695     Document Type: Article
Times cited : (52)

References (54)
  • 1
    • 0037337599 scopus 로고    scopus 로고
    • Fibroblast growth factors and their receptors in urological cancers: basic research and clinical implications
    • Cronauer MV, Schulz WA, Seifert HH, Ackermann R, Burchardt M, (2003) Fibroblast growth factors and their receptors in urological cancers: basic research and clinical implications. Eur Urol 43: 309-319.
    • (2003) Eur Urol , vol.43 , pp. 309-319
    • Cronauer, M.V.1    Schulz, W.A.2    Seifert, H.H.3    Ackermann, R.4    Burchardt, M.5
  • 2
  • 4
    • 4644223140 scopus 로고    scopus 로고
    • The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression
    • Wang J, Stockton DW, Ittmann M, (2004) The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression. Clin Cancer Res 10: 6169-6178.
    • (2004) Clin Cancer Res , vol.10 , pp. 6169-6178
    • Wang, J.1    Stockton, D.W.2    Ittmann, M.3
  • 5
    • 33644632444 scopus 로고    scopus 로고
    • Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway
    • Zhao P, Caretti G, Mitchell S, McKeehan WL, Boskey AL, et al. (2006) Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway. J Biol Chem 281: 429-438.
    • (2006) J Biol Chem , vol.281 , pp. 429-438
    • Zhao, P.1    Caretti, G.2    Mitchell, S.3    McKeehan, W.L.4    Boskey, A.L.5
  • 6
    • 84859415553 scopus 로고    scopus 로고
    • Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer
    • Brooks AN, Kilgour E, Smith PD, (2012) Molecular pathways: fibroblast growth factor signaling: a new therapeutic opportunity in cancer. Clin Cancer Res 18: 1855-1862.
    • (2012) Clin Cancer Res , vol.18 , pp. 1855-1862
    • Brooks, A.N.1    Kilgour, E.2    Smith, P.D.3
  • 7
    • 71049185005 scopus 로고    scopus 로고
    • Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays
    • Babel I, Barderas R, Diaz-Uriarte R, Martinez-Torrecuadrada JL, Sanchez-Carbayo M, et al. (2009) Identification of tumor-associated autoantigens for the diagnosis of colorectal cancer in serum using high density protein microarrays. Mol Cell Proteomics 8: 2382-2395.
    • (2009) Mol Cell Proteomics , vol.8 , pp. 2382-2395
    • Babel, I.1    Barderas, R.2    Diaz-Uriarte, R.3    Martinez-Torrecuadrada, J.L.4    Sanchez-Carbayo, M.5
  • 8
    • 84864113921 scopus 로고    scopus 로고
    • An optimized predictor panel for colorectal cancer diagnosis based on the combination of tumor-associated antigens obtained from protein and phage microarrays
    • Barderas R, Babel I, Diaz-Uriarte R, Moreno V, Suarez A, et al. (2012) An optimized predictor panel for colorectal cancer diagnosis based on the combination of tumor-associated antigens obtained from protein and phage microarrays. J Proteomics 75: 4647-4655.
    • (2012) J Proteomics , vol.75 , pp. 4647-4655
    • Barderas, R.1    Babel, I.2    Diaz-Uriarte, R.3    Moreno, V.4    Suarez, A.5
  • 9
    • 0036468871 scopus 로고    scopus 로고
    • Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele
    • Bange J, Prechtl D, Cheburkin Y, Specht K, Harbeck N, et al. (2002) Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. Cancer Res 62: 840-847.
    • (2002) Cancer Res , vol.62 , pp. 840-847
    • Bange, J.1    Prechtl, D.2    Cheburkin, Y.3    Specht, K.4    Harbeck, N.5
  • 11
    • 0036144332 scopus 로고    scopus 로고
    • Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis
    • Ezzat S, Zheng L, Zhu XF, Wu GE, Asa SL, (2002) Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis. J Clin Invest 109: 69-78.
    • (2002) J Clin Invest , vol.109 , pp. 69-78
    • Ezzat, S.1    Zheng, L.2    Zhu, X.F.3    Wu, G.E.4    Asa, S.L.5
  • 12
    • 56949101730 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention
    • Ho HK, Pok S, Streit S, Ruhe JE, Hart S, et al. (2009) Fibroblast growth factor receptor 4 regulates proliferation, anti-apoptosis and alpha-fetoprotein secretion during hepatocellular carcinoma progression and represents a potential target for therapeutic intervention. J Hepatol 50: 118-127.
    • (2009) J Hepatol , vol.50 , pp. 118-127
    • Ho, H.K.1    Pok, S.2    Streit, S.3    Ruhe, J.E.4    Hart, S.5
  • 13
    • 34548434816 scopus 로고    scopus 로고
    • Selective over-expression of fibroblast growth factor receptors 1 and 4 in clinical prostate cancer
    • Sahadevan K, Darby S, Leung HY, Mathers ME, Robson CN, et al. (2007) Selective over-expression of fibroblast growth factor receptors 1 and 4 in clinical prostate cancer. J Pathol 213: 82-90.
    • (2007) J Pathol , vol.213 , pp. 82-90
    • Sahadevan, K.1    Darby, S.2    Leung, H.Y.3    Mathers, M.E.4    Robson, C.N.5
  • 14
    • 78650211213 scopus 로고    scopus 로고
    • Loss of heterozygosity and DNA methylation affect germline fibroblast growth factor receptor 4 polymorphism to direct allelic selection in breast cancer
    • Zhu X, Zheng L, Asa SL, Ezzat S, (2010) Loss of heterozygosity and DNA methylation affect germline fibroblast growth factor receptor 4 polymorphism to direct allelic selection in breast cancer. Am J Pathol 177: 2860-2869.
    • (2010) Am J Pathol , vol.177 , pp. 2860-2869
    • Zhu, X.1    Zheng, L.2    Asa, S.L.3    Ezzat, S.4
  • 15
    • 84869221046 scopus 로고    scopus 로고
    • Differential effects of polymorphic alleles of FGF receptor 4 on colon cancer growth and metastasis
    • Heinzle C, Gsur A, Hunjadi M, Erdem Z, Gauglhofer C, et al. (2012) Differential effects of polymorphic alleles of FGF receptor 4 on colon cancer growth and metastasis. Cancer Res 72: 5767-5777.
    • (2012) Cancer Res , vol.72 , pp. 5767-5777
    • Heinzle, C.1    Gsur, A.2    Hunjadi, M.3    Erdem, Z.4    Gauglhofer, C.5
  • 16
    • 24744451851 scopus 로고    scopus 로고
    • FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer
    • Spinola M, Leoni VP, Tanuma J, Pettinicchio A, Frattini M, et al. (2005) FGFR4 Gly388Arg polymorphism and prognosis of breast and colorectal cancer. Oncol Rep 14: 415-419.
    • (2005) Oncol Rep , vol.14 , pp. 415-419
    • Spinola, M.1    Leoni, V.P.2    Tanuma, J.3    Pettinicchio, A.4    Frattini, M.5
  • 17
    • 70449450426 scopus 로고    scopus 로고
    • Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models
    • Taylor JGt, Cheuk AT, Tsang PS, Chung JY, Song YK, et al. (2009) Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J Clin Invest 119: 3395-3407.
    • (2009) J Clin Invest , vol.119 , pp. 3395-3407
    • Taylor, J.G.1    Cheuk, A.T.2    Tsang, P.S.3    Chung, J.Y.4    Song, Y.K.5
  • 18
    • 33644686223 scopus 로고    scopus 로고
    • Functional FGFR4 Gly388Arg polymorphism predicts prognosis in lung adenocarcinoma patients
    • Spinola M, Leoni V, Pignatiello C, Conti B, Ravagnani F, et al. (2005) Functional FGFR4 Gly388Arg polymorphism predicts prognosis in lung adenocarcinoma patients. J Clin Oncol 23: 7307-7311.
    • (2005) J Clin Oncol , vol.23 , pp. 7307-7311
    • Spinola, M.1    Leoni, V.2    Pignatiello, C.3    Conti, B.4    Ravagnani, F.5
  • 19
    • 54549094903 scopus 로고    scopus 로고
    • Somatic mutations affect key pathways in lung adenocarcinoma
    • Ding L, Getz G, Wheeler DA, Mardis ER, McLellan MD, et al. (2008) Somatic mutations affect key pathways in lung adenocarcinoma. Nature 455: 1069-1075.
    • (2008) Nature , vol.455 , pp. 1069-1075
    • Ding, L.1    Getz, G.2    Wheeler, D.A.3    Mardis, E.R.4    McLellan, M.D.5
  • 21
    • 20044381123 scopus 로고    scopus 로고
    • A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer
    • Stephens P, Edkins S, Davies H, Greenman C, Cox C, et al. (2005) A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nat Genet 37: 590-592.
    • (2005) Nat Genet , vol.37 , pp. 590-592
    • Stephens, P.1    Edkins, S.2    Davies, H.3    Greenman, C.4    Cox, C.5
  • 22
    • 48249118837 scopus 로고    scopus 로고
    • Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression
    • Wang J, Yu W, Cai Y, Ren C, Ittmann MM, (2008) Altered fibroblast growth factor receptor 4 stability promotes prostate cancer progression. Neoplasia 10: 847-856.
    • (2008) Neoplasia , vol.10 , pp. 847-856
    • Wang, J.1    Yu, W.2    Cai, Y.3    Ren, C.4    Ittmann, M.M.5
  • 23
    • 3142726255 scopus 로고    scopus 로고
    • Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma
    • Streit S, Bange J, Fichtner A, Ihrler S, Issing W, et al. (2004) Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma. Int J Cancer 111: 213-217.
    • (2004) Int J Cancer , vol.111 , pp. 213-217
    • Streit, S.1    Bange, J.2    Fichtner, A.3    Ihrler, S.4    Issing, W.5
  • 24
    • 0032822672 scopus 로고    scopus 로고
    • FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4
    • Xie MH, Holcomb I, Deuel B, Dowd P, Huang A, et al. (1999) FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine 11: 729-735.
    • (1999) Cytokine , vol.11 , pp. 729-735
    • Xie, M.H.1    Holcomb, I.2    Deuel, B.3    Dowd, P.4    Huang, A.5
  • 26
    • 0036086285 scopus 로고    scopus 로고
    • A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice
    • Nicholes K, Guillet S, Tomlinson E, Hillan K, Wright B, et al. (2002) A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. Am J Pathol 160: 2295-2307.
    • (2002) Am J Pathol , vol.160 , pp. 2295-2307
    • Nicholes, K.1    Guillet, S.2    Tomlinson, E.3    Hillan, K.4    Wright, B.5
  • 27
    • 37849029159 scopus 로고    scopus 로고
    • Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models
    • Desnoyers LR, Pai R, Ferrando RE, Hotzel K, Le T, et al. (2008) Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. Oncogene 27: 85-97.
    • (2008) Oncogene , vol.27 , pp. 85-97
    • Desnoyers, L.R.1    Pai, R.2    Ferrando, R.E.3    Hotzel, K.4    Le, T.5
  • 28
    • 84863338708 scopus 로고    scopus 로고
    • Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB
    • Yang C, Jin C, Li X, Wang F, McKeehan WL, et al. (2012) Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PLoS One 7: e33870.
    • (2012) PLoS One , vol.7
    • Yang, C.1    Jin, C.2    Li, X.3    Wang, F.4    McKeehan, W.L.5
  • 29
    • 0029047806 scopus 로고
    • Chromosomal markers associated with metastasis in two colon cancer cell lines established from the same patient
    • Gagos S, Hopwood VL, Iliopoulos D, Kostakis A, Karayannakos P, et al. (1995) Chromosomal markers associated with metastasis in two colon cancer cell lines established from the same patient. Anticancer Res 15: 369-378.
    • (1995) Anticancer Res , vol.15 , pp. 369-378
    • Gagos, S.1    Hopwood, V.L.2    Iliopoulos, D.3    Kostakis, A.4    Karayannakos, P.5
  • 31
    • 0023917842 scopus 로고
    • In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice
    • Morikawa K, Walker SM, Jessup JM, Fidler IJ, (1988) In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice. Cancer Res 48: 1943-1948.
    • (1988) Cancer Res , vol.48 , pp. 1943-1948
    • Morikawa, K.1    Walker, S.M.2    Jessup, J.M.3    Fidler, I.J.4
  • 32
    • 0024272364 scopus 로고
    • Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice
    • Morikawa K, Walker SM, Nakajima M, Pathak S, Jessup JM, et al. (1988) Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice. Cancer Res 48: 6863-6871.
    • (1988) Cancer Res , vol.48 , pp. 6863-6871
    • Morikawa, K.1    Walker, S.M.2    Nakajima, M.3    Pathak, S.4    Jessup, J.M.5
  • 33
    • 1942456800 scopus 로고    scopus 로고
    • Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma
    • Trudel S, Ely S, Farooqi Y, Affer M, Robbiani DF, et al. (2004) Inhibition of fibroblast growth factor receptor 3 induces differentiation and apoptosis in t(4;14) myeloma. Blood 103: 3521-3528.
    • (2004) Blood , vol.103 , pp. 3521-3528
    • Trudel, S.1    Ely, S.2    Farooqi, Y.3    Affer, M.4    Robbiani, D.F.5
  • 34
    • 21044443128 scopus 로고    scopus 로고
    • In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models
    • Lee SH, Lopes de Menezes D, Vora J, Harris A, Ye H, et al. (2005) In vivo target modulation and biological activity of CHIR-258, a multitargeted growth factor receptor kinase inhibitor, in colon cancer models. Clin Cancer Res 11: 3633-3641.
    • (2005) Clin Cancer Res , vol.11 , pp. 3633-3641
    • Lee, S.H.1    Lopes de Menezes, D.2    Vora, J.3    Harris, A.4    Ye, H.5
  • 35
    • 84861894074 scopus 로고    scopus 로고
    • High Expression of IL-13 Receptor alpha2 in Colorectal Cancer Is Associated with Invasion, Liver Metastasis, and Poor Prognosis
    • Barderas R, Bartolome RA, Fernandez-Acenero MJ, Torres S, Casal JI, (2012) High Expression of IL-13 Receptor alpha2 in Colorectal Cancer Is Associated with Invasion, Liver Metastasis, and Poor Prognosis. Cancer Res 72: 2780-2790.
    • (2012) Cancer Res , vol.72 , pp. 2780-2790
    • Barderas, R.1    Bartolome, R.A.2    Fernandez-Acenero, M.J.3    Torres, S.4    Casal, J.I.5
  • 36
    • 37049003993 scopus 로고    scopus 로고
    • Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines
    • Ruhe JE, Streit S, Hart S, Wong CH, Specht K, et al. (2007) Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines. Cancer Res 67: 11368-11376.
    • (2007) Cancer Res , vol.67 , pp. 11368-11376
    • Ruhe, J.E.1    Streit, S.2    Hart, S.3    Wong, C.H.4    Specht, K.5
  • 37
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • Scheel C, Eaton EN, Li SH, Chaffer CL, Reinhardt F, et al. (2011) Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell 145: 926-940.
    • (2011) Cell , vol.145 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.3    Chaffer, C.L.4    Reinhardt, F.5
  • 38
    • 71749092731 scopus 로고    scopus 로고
    • A combinatorial approach for the design of complementarity-determining region-derived peptidomimetics with in vitro anti-tumoral activity
    • Timmerman P, Barderas R, Desmet J, Altschuh D, Shochat S, et al. (2009) A combinatorial approach for the design of complementarity-determining region-derived peptidomimetics with in vitro anti-tumoral activity. J Biol Chem 284: 34126-34134.
    • (2009) J Biol Chem , vol.284 , pp. 34126-34134
    • Timmerman, P.1    Barderas, R.2    Desmet, J.3    Altschuh, D.4    Shochat, S.5
  • 41
    • 67649662034 scopus 로고    scopus 로고
    • Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
    • Nan H, Qureshi AA, Hunter DJ, Han J, (2009) Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study. BMC Cancer 9: 172.
    • (2009) BMC Cancer , vol.9 , pp. 172
    • Nan, H.1    Qureshi, A.A.2    Hunter, D.J.3    Han, J.4
  • 42
    • 0035866394 scopus 로고    scopus 로고
    • Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both angiogenesis-dependent and -independent mechanisms
    • Auguste P, Gursel DB, Lemiere S, Reimers D, Cuevas P, et al. (2001) Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both angiogenesis-dependent and-independent mechanisms. Cancer Res 61: 1717-1726.
    • (2001) Cancer Res , vol.61 , pp. 1717-1726
    • Auguste, P.1    Gursel, D.B.2    Lemiere, S.3    Reimers, D.4    Cuevas, P.5
  • 43
    • 24344461320 scopus 로고    scopus 로고
    • Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation
    • Martinez-Torrecuadrada J, Cifuentes G, Lopez-Serra P, Saenz P, Martinez A, et al. (2005) Targeting the extracellular domain of fibroblast growth factor receptor 3 with human single-chain Fv antibodies inhibits bladder carcinoma cell line proliferation. Clin Cancer Res 11: 6280-6290.
    • (2005) Clin Cancer Res , vol.11 , pp. 6280-6290
    • Martinez-Torrecuadrada, J.1    Cifuentes, G.2    Lopez-Serra, P.3    Saenz, P.4    Martinez, A.5
  • 44
    • 42249103255 scopus 로고    scopus 로고
    • Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis
    • Martinez-Torrecuadrada JL, Cheung LH, Lopez-Serra P, Barderas R, Canamero M, et al. (2008) Antitumor activity of fibroblast growth factor receptor 3-specific immunotoxins in a xenograft mouse model of bladder carcinoma is mediated by apoptosis. Mol Cancer Ther 7: 862-873.
    • (2008) Mol Cancer Ther , vol.7 , pp. 862-873
    • Martinez-Torrecuadrada, J.L.1    Cheung, L.H.2    Lopez-Serra, P.3    Barderas, R.4    Canamero, M.5
  • 45
    • 33646555792 scopus 로고    scopus 로고
    • The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells
    • Trudel S, Stewart AK, Rom E, Wei E, Li ZH, et al. (2006) The inhibitory anti-FGFR3 antibody, PRO-001, is cytotoxic to t(4;14) multiple myeloma cells. Blood 107: 4039-4046.
    • (2006) Blood , vol.107 , pp. 4039-4046
    • Trudel, S.1    Stewart, A.K.2    Rom, E.3    Wei, E.4    Li, Z.H.5
  • 46
    • 79955667838 scopus 로고    scopus 로고
    • Targeting mutant fibroblast growth factor receptors in cancer
    • Greulich H, Pollock PM, (2011) Targeting mutant fibroblast growth factor receptors in cancer. Trends Mol Med 17: 283-292.
    • (2011) Trends Mol Med , vol.17 , pp. 283-292
    • Greulich, H.1    Pollock, P.M.2
  • 47
    • 79953170258 scopus 로고    scopus 로고
    • Identification of MST1/STK4 and SULF1 proteins as autoantibody targets for the diagnosis of colorectal cancer by using phage microarrays
    • Babel I, Barderas R, Diaz-Uriarte R, Moreno V, Suarez A, et al. (2011) Identification of MST1/STK4 and SULF1 proteins as autoantibody targets for the diagnosis of colorectal cancer by using phage microarrays. Mol Cell Proteomics.
    • (2011) Mol Cell Proteomics
    • Babel, I.1    Barderas, R.2    Diaz-Uriarte, R.3    Moreno, V.4    Suarez, A.5
  • 48
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA, (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 49
    • 36649025928 scopus 로고    scopus 로고
    • Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition
    • Acevedo VD, Gangula RD, Freeman KW, Li R, Zhang Y, et al. (2007) Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition. Cancer Cell 12: 559-571.
    • (2007) Cancer Cell , vol.12 , pp. 559-571
    • Acevedo, V.D.1    Gangula, R.D.2    Freeman, K.W.3    Li, R.4    Zhang, Y.5
  • 50
    • 84862203852 scopus 로고    scopus 로고
    • FGFR1-Induced Epithelial to Mesenchymal Transition through MAPK/PLCgamma/COX-2-Mediated Mechanisms
    • Tomlinson DC, Baxter EW, Loadman PM, Hull MA, Knowles MA, (2012) FGFR1-Induced Epithelial to Mesenchymal Transition through MAPK/PLCgamma/COX-2-Mediated Mechanisms. PLoS One 7: e38972.
    • (2012) PLoS One , vol.7
    • Tomlinson, D.C.1    Baxter, E.W.2    Loadman, P.M.3    Hull, M.A.4    Knowles, M.A.5
  • 51
    • 33845809125 scopus 로고    scopus 로고
    • Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2
    • Chaffer CL, Brennan JP, Slavin JL, Blick T, Thompson EW, et al. (2006) Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Res 66: 11271-11278.
    • (2006) Cancer Res , vol.66 , pp. 11271-11278
    • Chaffer, C.L.1    Brennan, J.P.2    Slavin, J.L.3    Blick, T.4    Thompson, E.W.5
  • 52
    • 36549064806 scopus 로고    scopus 로고
    • Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias
    • de Frutos CA, Vega S, Manzanares M, Flores JM, Huertas H, et al. (2007) Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. Dev Cell 13: 872-883.
    • (2007) Dev Cell , vol.13 , pp. 872-883
    • de Frutos, C.A.1    Vega, S.2    Manzanares, M.3    Flores, J.M.4    Huertas, H.5
  • 53
    • 15944378835 scopus 로고    scopus 로고
    • CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma
    • Trudel S, Li ZH, Wei E, Wiesmann M, Chang H, et al. (2005) CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma. Blood 105: 2941-2948.
    • (2005) Blood , vol.105 , pp. 2941-2948
    • Trudel, S.1    Li, Z.H.2    Wei, E.3    Wiesmann, M.4    Chang, H.5
  • 54
    • 84866171951 scopus 로고    scopus 로고
    • Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models
    • French DM, Lin BC, Wang M, Adams C, Shek T, et al. (2012) Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models. PLoS One 7: e36713.
    • (2012) PLoS One , vol.7
    • French, D.M.1    Lin, B.C.2    Wang, M.3    Adams, C.4    Shek, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.