Influence of variants in the NPY gene on obesity and metabolic syndrome features in Spanish children

Peptides

Volumn 45, Issue , 2013, Pages 22-27

  Olza, Josune ^a   Gil Campos, Mercedes ^b   Leis, Rosaura ^c   Rupérez, Azahara I ^a   Tojo, Rafael ^c   Cañete, Ramón ^b   Gil, Ángel ^a   Aguilera, Concepción M ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^c Instituto de Salud Carlos III   (Spain)

Author keywords

Children; Metabolic syndrome features; NPY variants; Obesity

Indexed keywords

ADIPOCYTOKINE; BIOLOGICAL MARKER; CHOLESTEROL; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GELATINASE B; GLUCOSE; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NEUROPEPTIDE Y; RESISTIN; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; TRIACYLGLYCEROL;

ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHILD; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MULTICENTER STUDY; OBESITY; PEDIATRICS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; SPAIN; WAIST CIRCUMFERENCE; ADOLESCENT; BLOOD; CARDIOVASCULAR DISEASES; CASE CONTROL STUDY; COMPLICATION; GENETICS; GENOTYPING TECHNIQUE; RISK FACTOR;

ADOLESCENT; BIOLOGICAL MARKERS; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CYTOKINES; FEMALE; GENOTYPING TECHNIQUES; HUMANS; LEPTIN; MALE; METABOLIC SYNDROME X; NEUROPEPTIDE Y; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RESISTIN; RISK FACTORS; SPAIN; TRIGLYCERIDES; WAIST CIRCUMFERENCE;

EID: 84877829892     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2013.04.007     Document Type: Article

References (33)

1. C.J. Billington, J.E. Briggs, M. Grace, and A.S. Levine Effects of intracerebroventricular injection of neuropeptide Y on energy metabolism Am J Physiol 260 1991 R321 R327
2. M.S. Bray, E. Boerwinkle, and C.L. Hanis Sequence variation within the neuropeptide Y gene and obesity in Mexican Americans Obes Res 8 2000 219 226
3. S.P. Brothers, and C. Wahlestedt Therapeutic potential of neuropeptide Y (NPY) receptor ligands EMBO Mol Med 2 2010 429 439
4. E. Bruinstroop, L. Pei, M.T. Ackermans, E. Foppen, E. Foppen, and A.J. Borgers Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL-triglyceride secretion in rats via the sympathetic nervous system Diabetes 61 2012 1043 1050
5. T.J. Cole, M.C. Bellizzi, K.M. Flegal, and W.H. Dietz Establishing a standard definition for child overweight and obesity worldwide: international survey BMJ 320 2000 1240 1243 (Pubitemid 30240471)
6. B. Ding, B. Kull, Z. Liu, S. Mottagui-Tabar, H. Thonberg, and H.F. Gu Human neuropeptide Y signal peptide gain-of-function polymorphism is associated with increased body mass index: possible mode of function Regul Pept 127 2005 45 53 (Pubitemid 40179241)
7. S. Hohmann, A.F. Buchmann, S.H. Witt, M. Rietschel, C. Jennen-Steinmetz, and M.H. Schmidt Increasing association between a neuropeptide Y promoter polymorphism and body mass index during the course of development Pediatr Obes 7 2012 453 460
8. U. Jaakkola, T. Kakko, M. Juonala, T. Lehtimäki, J. Viikari, and A.E. Jääskeläinen Neuropeptide Y polymorphism increases the risk for asthma in overweight subjects; protection from atherosclerosis in asthmatic subjects - the cardiovascular risk in young Finns study Neuropeptides 46 2012 321 328
9. M.K. Karvonen, M. Koulu, U. Pesonen, M.I. Uusitupa, A. Tammi, and J. Viikari Leucine 7 to proline 7 polymorphism in the preproneuropeptide Y is associated with birth weight and serum triglyceride concentration in preschool aged children J Clin Endocrinol Metab 85 2000 1455 1460 (Pubitemid 32289486)
10. M.K. Karvonen, U. Pesonen, M. Koulu, L. Niskanen, M. Laakso, and A. Rissanen Association of a leucine (7)-to-proline (7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels Nat Med 4 1998 1434 1437 (Pubitemid 28553469)
11. M.K. Karvonen, V.P. Valkonen, T.A. Lakka, R. Salonen, M. Koulu, and U. Pesonen Leucine7 to proline7 polymorphism in the preproneuropeptide Y is associated with the progression of carotid atherosclerosis, blood pressure and serum lipids in Finnish men Atherosclerosis 159 2001 145 151 (Pubitemid 33016631)
12. N.S. Kim, S.M. Oh, M.M. Ko, M.H. Cha, B.K. Kang, and O.S. Bang Association of the C-399T promoter polymorphism of neuropeptide Y with susceptibility to ischemic stroke Clin Biochem 42 2009 1699 1704
13. C. Lee, and M. Kong An interactive association of common sequence variants in the neuropeptide Y gene with susceptibility to ischemic stroke Stroke 38 2007 2663 2669 (Pubitemid 47494001)
14. C.M. Licht, S.A. Vreeburg, A.K. van Reedt Dortland, E.J. Giltay, W.J. Hoogendijk, and R.H. DeRijk Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities J Clin Endocrinol Metab 95 2010 2458 2466
15. A. Masoudi Kazemabad, K. Jamialahmadi, M. Moohebati, M. Mojarrad, R.D. Manshadi, and S. Akhlaghi Neuropeptide Y Leu7Pro polymorphism associated with the metabolic syndrome and its features in patients with coronary artery disease Angiology 64 2013 40 45
16. B.W. McCrindle Assessment and management of hypertension in children and adolescent Nat Rev Cardiol 7 2010 155 163
17. L. Niskanen, M.K. Karvonen, R. Valve, M. Koulu, U. Pesonen, and M. Mercuri Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects J Clin Endocrinol Metab 85 2000 2266 2269 (Pubitemid 32269253)
18. S. Nordman, B. Ding, C.G. Ostenson, L. Kärvestedt, K. Brismar, and S. Efendic Leu7Pro polymorphism in the neuropeptide Y (NPY) gene is associated with impaired glucose tolerance and type 2 diabetes in Swedish men Exp Clin Endocrinol Diabetes 113 2005 282 287 (Pubitemid 40868184)
19. J.M. Rojas, J.M. Stafford, S. Saadat, R.L. Printz, A.G. Beck-Sickinger, and K.D. Niswender Central nervous system neuropeptide Y signaling via the Y1 receptor partially dissociates feeding behavior from lipoprotein metabolism in lean rats Am J Physiol Endocrinol Metab 303 2012 E1479 E1488
20. S.T. Ruohonen, U. Pesonen, N. Moritz, K. Kaipio, M. Roytta, and M. Koulu Transgenic mice overexpressing neuropeptide Y in noradrenergic neurons Diabetes 57 2008 1517 1525
21. A. Sainsbury, F. Rohner-Jeanrenaud, I. Cusin, K.E. Zakrzewska, P.A. Halban, and R.C. Gaillard Chronic central neuropeptide Y infusion in normal rats: status of the hypothalamo-pituitary-adrenal axis, and vagal mediation of hyperinsulinaemia Diabetologia 40 1997 1269 1277 (Pubitemid 27469666)
22. M. Salminen, T. Lehtimaki, Y.M. Fan, T. Vahlberg, and S.L. Kivela Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene and changes in serum lipids during a family-based counselling intervention among school-aged children with a family history of CVD Public Health Nutr 11 2008 1156 1162
23. S.H. Shah, N.J. Freedman, L. Zhang, D.R. Crosslin, D.H. Stone, and C. Haynes Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis PLoS Genet 5 2009 e1000318
24. N.S. Singhal, M.A. Lazar, and R.S. Ahima Central resistin induces hepatic insulin resistance via neuropeptide Y J Neurosci 27 2007 12924 12932 (Pubitemid 350159588)
25. B.G. Stanley, S.E. Kyrkouli, S. Lampert, and S.F. Leibowitz Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity Peptides 7 1986 1189 1192 (Pubitemid 17226746)
26. O. Ukkola, and Y.A. Kesaniemi Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects Eur J Clin Nutr 61 2007 1102 1105 (Pubitemid 47386596)
27. A.M. van den Hoek, C. van Heijningen, J.P. Schröder-van der Elst, D.M. Ouwens, L.M. Havekes, and J.A. Romijn Intracerebroventricular administration of neuropeptide Y induces hepatic insulin resistance via sympathetic innervation Diabetes 57 2008 2304 2310
28. C.T. van Rossum, H. Pijl, R.A. Adan, B. Hoebee, and J.C. Seidell Polymorphisms in the NPY and AGRP genes and body fatness in Dutch adults Int J Obes (Lond) 30 2006 1522 1528 (Pubitemid 44470201)
29. R. Vettor, N. Zarjevski, I. Cusin, F. Rohner-Jeanrenaud, and B. Jeanrenaud Induction and reversibility of an obesity syndrome by intracerebroventricular neuropeptide Y administration to normal rats Diabetologia 37 1994 1202 1208 (Pubitemid 24356759)
30. E.H. Yeung, C. Zhang, J. Chen, K. Bowers, F.B. Hu, and G. Kang Polymorphisms in the neuropeptide Y gene and the risk of obesity: findings from two prospective cohorts J Clin Endocrinol Metab 96 2011 E2055 E2062
31. J.T. Yu, N.N. Yu, S.S. Gao, J.H. Song, T. Ma, and N.D. Wang Neuropeptide Y polymorphisms and ischemic stroke in Chinese population Clin Chim Acta 411 2010 242 245
32. X. Zhang, Q. Qi, J. Liang, F.B. Hu, F.M. Sacks, and L. Qi Neuropeptide y promoter polymorphism modifies effects of a weight-loss diet on 2-year changes of blood pressure: the preventing overweight using novel dietary strategies trial Hypertension 60 2012 1169 1175
33. Z. Zhou, G. Zhu, A.R. Hariri, M.A. Enoch, D. Scott, and R. Sinha Genetic variation in human NPY expression affects stress response and emotion Nature 452 2008 997 1001 (Pubitemid 351589618)