Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects

Journal of Clinical Endocrinology and Metabolism

Volumn 85, Issue 6, 2000, Pages 2266-2269

  Niskanen, Leo ^a   Karvonen, Matti K ^c   Valve, Raisa ^a   Koulu, Markku ^c   Pesonen, Ullamari ^c   Mercuri, Michele ^d   Rauramaa, Rainer ^a,b   Töyry, Jari ^a,b   Laakso, Markku ^a   Uusitupa, Matti I J ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE; NEUROPEPTIDE Y; PROLINE;

ADULT; AGED; ARTERY INTIMA PROLIFERATION; ARTICLE; BRAIN ATHEROSCLEROSIS; CONTROLLED STUDY; DNA POLYMORPHISM; ECHOGRAPHY; FEMALE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL;

AGED; AMINO ACID SUBSTITUTION; ARTERIOSCLEROSIS; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; CAROTID STENOSIS; COHORT STUDIES; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FEMALE; GENOTYPE; HEART RATE; HUMANS; LEUCINE; MALE; NEUROPEPTIDE Y; POLYMORPHISM, GENETIC; PROLINE; RISK FACTORS;

EID: 17744393296     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.85.6.2266     Document Type: Article

References (25)

1. Neuropeptides in the sympathetic system: Presence, plasticity, modulation, and implications
2. Neuropeptide Y, the hypothalamus and the regulation of energy homeostasis
3. Life without neuropeptide Y
4. Neuropeptide Y: A novel angiogenic factor from the sympathetic nerves and endothelium
5. Evidence that hypothalamic neuropeptide Y gene expression and NPY levels in the paraventricular nucles increase before the onset of hyperphagia in experimental diabetes
6. Neuropeptide Y and regulation of the cardiovascular system
7. Decreased cardio-respiratory effects of neuropeptide Y in the nucleus tractus solitarius in diabetes
8. Selective attenuation of neuropeptide-Y-mediated contractile responses in blood vessels from patients with diabetes mellitus
9. Evolution of the neuropeptide Y family and its receptors
10. Association of a leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y with high serum cholesterol and LDL cholesterol levels
11. Prevalence of coronary heart disease, left ventricular failure and hypertension in middle-aged, newly diagnosed type 2 (non-insulin-dependent) diabetic subjects
12. Five-year follow-up study on plasma insulin levels in newly diagnosed NIDDM patients and nondiabetic subjects
13. Ten-year cardiovascular mortality in relation to risk factors and abnormalities in lipoprotein composition in type 2 (non-insulin-dependent) diabetic and non-diabetic subjects
14. Metabolic evolution of type 2 diabetes: 10-year follow-up study
15. Autoantibodies against oxidized LDL as predictors of atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus
16. Carotid artery intima-media thickness in elderly patients with NIDDM and in nondiabetic subjects
17. Occurrence, predictors, and clinical significance of autonomic neuropathy in NIDDM: 10-year follow-up from the diagnosis
18. Baseline reproducibility of B-mode ultrasound imaging measurements of carotid intimal media thickness: The Multicenter Isradipine Diuretic Atherosclerosis Study (MIDAS)
19. Association of risk factors and body iron status to carotid atherosclerosis in middle-aged eastern Finnish men
20. Do high proinsulin and C-peptide levels play a role in autonomic nervous dysfunction? Power spectral analysis in patients with non-insulin-dependent diabetes and nondiabetic subjects?
21. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults
22. Diabetes, other risk factors and 12-years cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial
23. Mitogenic effect of neuropeptide Y in rat vascular smooth muscle cells
24. Neuropeptide Y stimulates DNA synthesis in vascular smooth muscle cells