A quantitative study of abnormally enlarged neurons in cognitively normal brain and neurodegenerative disease

Clinical Neuropathology

Volumn 32, Issue 2, 2013, Pages 128-134

  Armstrong, Richard A ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

95th percentile (95P); Abnormally enlarged neurons (AEN); Cognitively normal brain; Neurodegenerative disease; Ratio of cell diameter to nucleus diameter (CD ND)

Indexed keywords

ABNORMALLY ENLARGED NEURON; ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN DISEASE; BRAIN REGION; CELL POPULATION; CELL SIZE; CLINICAL ARTICLE; COGNITION; CORTICOBASAL DEGENERATION; DEGENERATIVE DISEASE; FEMALE; HUMAN; HUMAN TISSUE; LEWY BODY; MALE; PRIORITY JOURNAL; QUANTITATIVE STUDY;

ADULT; AGED; AGED, 80 AND OVER; BRAIN; FEMALE; HUMANS; MALE; MIDDLE AGED; NEURODEGENERATIVE DISEASES; NEURONS;

EID: 84877825625     PISSN: 07225091     EISSN: None     Source Type: Journal    
DOI: 10.5414/NP300516     Document Type: Article

References (30)

1. Tomlinson BE. Ageing and the dementias. In: Adams JH, Duchen LW (eds). Greenfield's Neuropathology. London: Edward Arnold; 1992.
2. Mori H, Oda M. Ballooned neurons in corticobasal degeneration and progressive supranuclear palsy. Neuropathology. 1997; 17: 248-252. doi:10.1111/j.1440-1789.1997.tb00047.x
3. Probst A, Tolnay M. (Argyrophilic grain disease (AgD), a frequent and largely underestimated cause of dementia in old patients). Rev Neurol (Paris). 2002; 158: 155-165. PubMed
4. Fujino Y, Delucia MW, Davies P, Dickson DW. Ballooned neurones in the limbic lobe are associated with Alzheimer type pathology and lack diagnostic specificity. Neuropathol Appl Neurobiol. 2004; 30: 676-682. doi:10.1111/j.1365-2990.2004.00593.x PubMed
5. Kato S, Hirano A, Umahara T, Llena JF, Herz F, Ohama E. Ultrastructural and immunohistochemical studies on ballooned cortical neurons in Creutzfeldt-Jakob disease: expression of alpha B-crystallin, ubiquitin and stress-response protein 27. Acta Neuropathol. 1992; 84: 443- 448. doi:10.1007/BF00227673 PubMed
6. Kovacs GG, Voigtländer T, Hainfellner JA, Budka H. Distribution of intraneuronal immunoreactivity for the prion protein in human prion diseases. Acta Neuropathol. 2002; 104: 320- 326. PubMed
7. Armstrong RA, Lantos PL, Cairns NJ. A quantitative study of the pathological changes in cortical neurons in sporadic Creutzfeldt-Jakob disease. Neuropathology. 2003; 23: 181-187. doi:10.1046/j.1440-1789.2003.00495.x
8. Wakabayashi K, Takahashi H. Pathological heterogeneity in progressive supranuclear palsy and corticobasal degeneration. Neuropathology. 2004; 24: 79-86. doi:10.1111/j.1440-1789.2003.00543.x PubMed
9. Mizuno Y, Takeuchi T, Takatama M, Okamoto K. Expression of nestin in ballooned neurons in patients with Creutzfeldt-Jakob disease. Neurosci Lett. 2004; 366: 144-147. doi:10.1016/j.neulet. 2004.05.033 PubMed
10. Armstrong RA, Cairns NJ, Lantos PL. The spatial pattern of Pick bodies, Pick cells and Alzheimer disease pathology in Pick's disease. Neuropathology. 1999; 19: 64-70. doi:10.1046/ j.1440-1789.1999.00219.x
11. Armstrong RA, Cairns NJ, Lantos PL. A quantitative study of the pathological lesions in the neocortex and hippocampus of twelve patients with corticobasal degeneration. Exp Neurol. 2000; 163: 348-356. doi:10.1006/exnr.2000.7392 PubMed
12. Mackenzie IRA, Hudson LP. Achromatic neurons in the cortex of progressive supranuclear palsy. Acta Neuropathol. 1995; 90: 615-619. doi:10.1007/BF00318574 PubMed
13. Bu B, Li J, Davies P, Vincent I. Deregulation of cdk5, hyperphosphorylation, and cytoskeletal pathology in the Niemann-Pick type C murine model. J Neurosci. 2002; 22: 6515-6525. PubMed
14. Distl R, Treiber-Held S, Albert F, Meske V, Harzer K, Ohm TG. Cholesterol storage and tau pathology in Niemann-Pick type C disease in the brain. J Pathol. 2003; 200: 104-111. doi:10.1002/ path.1320 PubMed
15. Armstrong RA, Cairns NJ, Lantos PL. Quantification of pathological lesions in the frontal and temporal lobe of ten patients diagnosed with Pick's disease. Acta Neuropathol. 1999; 97: 456-462. doi:10.1007/s004010051014 PubMed
16. Aoki K, Uchihara T, Nakamura A, Komori T, Arai N, Mizutani T. Expression of apolipoprotein E in ballooned neurons-comparative immunohistochemical study on neurodegenerative disorders and infarction. Acta Neuropathol. 2003; 106: 436-440. doi:10.1007/s00401-003- 0740-z PubMed
17. Minami M, Mizutani T, Kawanishi R, Suzuki Y, Mori H. Neuronal expression of alphaB crystallin in cerebral infarction. Acta Neuropathol. 2003; 105: 549-554. PubMed
18. Tierney MC, Fisher RH, Lewis AJ, Zorzitto ML, Snow WG, Reid DW, Nieuwstraten P. The NINCDS-ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease: a clinicopathologic study of 57 cases. Neurology. 1988; 38: 359-364. PubMed
19. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L. The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardisation of the neuropathological assessment of Alzheimer's disease. Neurology. 1991; 41: 479-486. PubMed
20. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen ENH et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology. 1996; 47: 1113-1124. PubMed
21. Litvan I, Agid Y, Calne D, Campbell G, Dubois B, Duvoisin RC, Goetz CG, Golbe LI, Grafman J, Growdon JH, Hallett M, Jankovic J, Quinn NP, Tolosa E, Zee DS, Chase TW, FitzGibbon EJ, Hall Z, Juncos J, Nelson KB et al. Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): report of the NINDS-SPSP international workshop. Neurology. 1996; 47: 1-9. PubMed
22. Hauw JJ, Daniel SE, Dickson D, Horoupian DS, Jellinger K, Lantos PL, McKee A, Tabaton M, Litvan I. Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (PSP). Neurology. 1994; 44: 2015- 2019. PubMed
23. Gilman S, Low PA, Quinn N, Albanese A, Ben- Shlomo Y, Fowler CJ, Kaufmann H, Klockgether T, Lang AE, Lantos PL, Litvan I, Mathias CJ, Oliver E, Robertson D, Schatz I, Wenning GK. Consensus statement on the diagnosis of multiple system atrophy. J Auton Nerv Syst. 1998; 74: 189-192. PubMed
24. Budka H, Aguzzi A, Brown P, Brucher JM, Bugiani O, Gullotta F, Haltia M, Hauw JJ, Ironside JW, Jellinger K, Kretzschmar HA, Lantos PL, Masullo C, Schlote W, Tateishi J, Weller RO. Neuropathological diagnostic criteria for Creutzfeldt-Jakob disease (CJD) and other human spongiform encephalopathies (prion diseases). Brain Pathol. 1995; 5: 459-466. doi:10.1111/j.1750-3639.1995.tb00625.x PubMed
25. Armstrong RA. Methods of studying the planar distribution of objects in histological sections of brain tissue. J Microsc. 2006; 221: 153-158. doi:10.1111/j.1365-2818.2006.01559.x PubMed
26. Mizuno Y, Hori S, Kakizuka A, Okamoto K. Vacuole-creating protein in neurodegenerative diseases in humans. Neurosci Lett. 2003; 343: 77-80. doi:10.1016/S0304-3940(03)00280-5 PubMed
27. Roeber S, Krebs B, Neumann M, Windl O, Zerr I, Grasbon-Frodl EM, Kretzschmar HA. Creutzfeldt- Jakob disease in a patient with an R208H mutation of the prion protein gene (PRNP) and a 17-kDa prion protein fragment. Acta Neuropathol. 2005; 109: 443-448. doi:10.1007/ s00401-004-0978-0 PubMed
28. Armstrong RA, Cairns NJ, Lantos PL. A quantitative study of the pathological changes in ten patients with multiple system atrophy (MSA). J Neural Transm. 2004; 111: 485-495. doi:10.1007/s00702-003-0105-8 PubMed
29. Pierucci A, de Oliveira AL. Increased sensory neuron apoptotic death 2 weeks after peripheral axotomy in C57BL/6J mice compared to A/J mice. Neurosci Lett. 2006; 396: 127-131. doi:10.1016/j.neulet.2005.11.024 PubMed
30. Tandrup T. Chromatolysis of A-cells of dorsal root ganglia is a primary structural event in acute acrylamide intoxication. J Neurocytol. 2002; 31: 73-78. doi:10.1023/A:1022531901090 PubMed