Hypersensitivity to polyethylene glycols

Journal of Clinical Pharmacology

Volumn 53, Issue 3, 2013, Pages 352-355

  Shah, Sapna ^a   Prematta, Tracy ^a   Adkinson, N Franklin ^b   Ishmael, Faoud T ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clinical pharmacology; Dermatology; Immunopharmacology; Rheumatology immunology; Toxicology

Indexed keywords

ADALIMUMAB; ADRENALIN; BENZETHONIUM CHLORIDE; BENZOCAINE; COTRIMOXAZOLE; GLYCEROL; LAXATIVE; MACROGOL; MACROGOL 10000; MACROGOL 200; MACROGOL 300; MACROGOL 3350; MACROGOL 400; MACROGOL 4000; MACROGOL 9000; MESALAZINE; METRONIDAZOLE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; POLYSORBATE 80; SUNSCREEN; TOLNAFTATE; UNCLASSIFIED DRUG; USTEKINUMAB;

ADULT; ARTICLE; CASE REPORT; CHEMICAL COMPOSITION; CLOSTRIDIUM DIFFICILE INFECTION; COLONOSCOPY; DELAYED HYPERSENSITIVITY; DIZZINESS; DRUG HYPERSENSITIVITY; DRUG SAFETY; DYSPNEA; FLUSHING; HUMAN; IMMEDIATE TYPE HYPERSENSITIVITY; MALE; MEDICAL HISTORY; PATCH TEST; PRICK TEST; TACHYCARDIA; ULCERATIVE COLITIS; UNCONSCIOUSNESS; URTICARIA;

HUMANS; HYPERSENSITIVITY, IMMEDIATE; MALE; MIDDLE AGED; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; SKIN TESTS;

EID: 84877810420     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270012447122     Document Type: Article

References (20)

1. Knop K, Hoogenboom R, Fischer D, Schubert US. Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angew Chem Int Ed Engl . 2010;49:6288-6308.
2. Bajaj AK, Gupta SC, Chatterjee AK, Singh KG. Contact sensitivity to polyethylene glycols. Contact Dermatitis . 1990;22:291-292.
3. Braun, W. [Contact allergies to polyethylene glycols]. Z Haut Geschlechtskr . 1969;44:385-389.
4. Fisher AA. Immediate and delayed allergic contact reactions to polyethylene glycol. Contact Dermatitis . 1978;4:135-138.
5. Guijarro SC, Sanchez-Perez J, Garcia-Diez A. Allergic contact dermatitis to polyethylene glycol and nitrofurazone. Am J Contact Dermat . 1999;10:226-227.
6. Isaksson M. Occupational allergic contact dermatitis from PEG-4 rapeseed amide in a massage oil. Contact Dermatitis . 2002;47:175-176.
7. Kalavala, M., Hughes TM, Stone NM. Allergic contact dermatitis to polyethylene glycol-7 hydrogenated castor oil. Contact Dermatitis . 2007;56:287-288.
8. Stenveld HJ, Langendijk PN, Bruynzeel DP. Contact sensitivity to polyethylene glycols. Contact Dermatitis . 1994;30:184-185.
9. Anton Gironés M, Roan Roan J, de la Hoz B, Sanchez Cano M. Immediate allergic reactions by polyethylene glycol 4000: two cases. Allergol Immunopathol (Madr) . 2008;36:110-112.
10. Geleijnse ML, Nemes A, Vletter WB, et al. Adverse reactions after the use of sulphur hexafluoride (SonoVue) echo contrast agent. J Cardiovasc Med (Hagerstown) . 2009;10:75-77.
11. Richter AW, Akerblom, E. Polyethylene glycol reactive antibodies in man: titer distribution in allergic patients treated with monomethoxy polyethylene glycol modified allergens or placebo, and in healthy blood donors. Int Arch Allergy Appl Immunol . 1984;74:36-39.
12. Almer S, Franzen L, Olaison G, Smedh K, Strom M. Increased absorption of polyethylene glycol 600 deposited in the colon in active ulcerative colitis. Gut . 1993;34:509-513.
13. Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology . 2011;140: 1756-1767.
14. Barbaud A. Place of excipients in drug-related allergy. Clin Rev Allergy Immunol. 1995;13:253-263.
15. Leuppi JD, Schnyder P, Hartmann K, et al. Drug-induced bronchospasm: analysis of 187 spontaneously reported cases. Respiration. 2001;68:345-351.
16. Mumoli N, Cei M, Luschi R, et al. Allergic reaction to Croscarmellose sodium used as excipient of a generic drug. QJM. 2011;104:709-710.
17. Osterberg RE, See NA. Toxicity of excipients-A Food and Drug Administration perspective. Int J Toxicol. 2003;22:377-380.
18. Strom BL, Schinnar R, Apter AJ, et al. Absence of cross-reactivity between sulfonamide antibiotics and sulfonamide nonantibiotics. N Engl J Med. 2003;349:1628-1635.
19. Purcell RT, Lockey RF. Immunologic responses to therapeutic biologic agents. J Investig Allergol Clin Immunol . 2008;18:335-342.
20. Pérez-Pérez L, Garcia-Gavin J, Pineiro B, Zulaica A. Biologicinduced urticaria due to polysorbate 80: usefulness of prick test. Br J Dermatol . 2011;164:1119-1120.