Growth retardation and hair loss in transgenic mice overexpressing human H-ferritin gene

Transgenic Research

Volumn 22, Issue 3, 2013, Pages 651-658

  Hasegawa, Sumitaka ^a   Harada, Kazutoshi ^b   Morokoshi, Yukie ^a   Tsukamoto, Satoshi ^a   Furukawa, Takako ^a   Saga, Tsuneo ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Growth retardation; H ferritin; Hair loss; Transgenic mouse

Indexed keywords

APOFERRITIN; IRON;

ALOPECIA; ANIMAL; ARTICLE; BLOOD; BODY WEIGHT; EPIDERMIS; ERYTHROCYTE COUNT; GENE EXPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HAIR FOLLICLE; HUMAN; HYPERPLASIA; KERATOSIS; METABOLISM; MOUSE; PATHOLOGY; TRANSGENIC MOUSE;

ALOPECIA; ANIMALS; APOFERRITINS; BODY WEIGHT; EPIDERMIS; ERYTHROCYTE COUNT; GENE EXPRESSION; HAIR FOLLICLE; HUMANS; HYPERPLASIA; IRON; KERATOSIS; MICE; MICE, TRANSGENIC;

MUS; MUS MUSCULUS;

EID: 84877791198     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-012-9669-0     Document Type: Article

References (18)

1. Alkhateeb AA, Connor JR (2010) Nuclear ferritin: a new role for ferritin in cell biology. Biochim Biophys Acta 1800: 793-797.
2. Arosio P, Ingrassia R, Cavadini P (2009) Ferritins: a family of molecules for iron storage, antioxidation and more. Biochim Biophys Acta 1790: 589-599.
3. Aung W, Hasegawa S, Furukawa T, Saga T (2007) Potential role of ferritin heavy chain in oxidative stress and apoptosis in human mesothelial and mesothelioma cells: implications for asbestos-induced oncogenesis. Carcinogenesis 28: 2047-2052.
4. Candi E, Schmidt R, Melino G (2005) The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol 6: 328-340.
5. Coffman LG, Parsonage D, D'Agostino R Jr, Torti FM, Torti SV (2009) Regulatory effects of ferritin on angiogenesis. Proc Natl Acad Sci USA 106: 570-575.
6. Cozzi A, Corsi B, Levi S, Santambrogio P, Albertini A, Arosio P (2000) Overexpression of wild type and mutated human ferritin H-chain in HeLa cells: in vivo role of ferritin ferroxidase activity. J Biol Chem 275: 25122-25129.
7. Darshan D, Vanoaica L, Richman L, Beermann F, Kuhn LC (2009) Conditional deletion of ferritin H in mice induces loss of iron storage and liver damage. Hepatology 50: 852-860.
8. Du X, She E, Gelbart T, Truksa J, Lee P, Xia Y, Khovananth K, Mudd S, Mann N, Moresco EM, Beutler E, Beutler B (2008) The serine protease TMPRSS6 is required to sense iron deficiency. Science 320: 1088-1092.
9. Ferreira C, Bucchini D, Martin ME, Levi S, Arosio P, Grandchamp B, Beaumont C (2000) Early embryonic lethality of H ferritin gene deletion in mice. J Biol Chem 275: 3021-3024.
10. Folgueras AR, de Lara FM, Pendas AM, Garabaya C, Rodriguez F, Astudillo A, Bernal T, Cabanillas R, Lopez-Otin C, Velasco G (2008) Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood 112: 2539-2545.
11. Fuchs E, Cleveland DW (1998) A structural scaffolding of intermediate filaments in health and disease. Science 279: 514-519.
12. Hasegawa S, Saito S, Takanashi J, Morokoshi Y, Furukawa T, Saga T, Aoki I (2011) Evaluation of ferritin-overexpressing brain in newly developed transgenic mice. Magn Reson Imaging 29: 179-184.
13. Lee D, Prowse DM, Brissette JL (1999) Association between mouse nude gene expression and the initiation of epithelial terminal differentiation. Dev Biol 208: 362-374. doi: 10. 1006/dbio. 1999. 9221.
14. Mecklenburg L, Tychsen B, Paus R (2005) Learning from nudity: lessons from the nude phenotype. Exp Dermatol 14: 797-810. doi: 10. 1111/j. 1600-0625. 2005. 00362. x.
15. Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, Sirito M, Sawadogo M, Kahn A, Vaulont S (2002) Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 99: 4596-4601.
16. Sakai K, Miyazaki J (1997) A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. Biochem Biophys Res Commun 237: 318-324.
17. Vanoaica L, Darshan D, Richman L, Schumann K, Kuhn LC (2010) Intestinal ferritin H is required for an accurate control of iron absorption. Cell Metab 12: 273-282.
18. Wilkinson JT, Di X, Schonig K, Buss JL, Kock ND, Cline JM, Saunders TL, Bujard H, Torti SV, Torti FM (2006) Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo. Biochem J 395: 501-507.