Evaluation of the in vitro cytotoxicity of cross-linked biomaterials

Biomacromolecules

Volumn 14, Issue 5, 2013, Pages 1321-1329

  Wang, Martha O ^a   Etheridge, Julie M ^a   Thompson, Joshua A ^a   Vorwald, Charlotte E ^a   Dean, David ^b   Fisher, John P ^a  

^a UNIVERSITY OF MARYLAND   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; CELL CULTURE; CROSSLINKING; CYTOTOXICITY; FLUORESCENCE; HIGH DENSITY POLYETHYLENES; METABOLISM; PROPYLENE; SOLS; STEM CELLS; TISSUE;

BONE TISSUE ENGINEERING; BONE TISSUE SCAFFOLDS; CROSS-LINKING DENSITY; FLUORESCENCE IMAGING; HUMAN MESENCHYMAL STEM CELLS; MESENCHYMAL STEM CELL; POLYPROPYLENE FUMARATE; ZINC DIETHYLDITHIO CARBAMATES;

SCAFFOLDS (BIOLOGY);

BIOMATERIAL; POLY(PROPYLENE FUMARATE); POLYETHYLENE; POLYURETHAN; TISSUE SCAFFOLD; UNCLASSIFIED DRUG; DIETHYLDITHIOCARBAMIC ACID; FUMARIC ACID DERIVATIVE; POLYPROPYLENE;

ANIMAL CELL; ARTICLE; BONE TISSUE; CELL ACTIVITY; CELL CULTURE; CELL METABOLISM; CELL STRAIN L 929; CELL STRUCTURE; CELL TYPE; CELL VACUOLE; CROSS LINKING; CYTOTOXICITY; FIBROBLAST; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; TISSUE ENGINEERING; ANIMAL; CELL ADHESION; CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DOG; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; LIGHT; MESENCHYMAL STROMA CELL; METABOLISM; MOUSE; TISSUE SCAFFOLD; TOXICITY;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL ADHESION; CELL LINE; CELL SURVIVAL; DITIOCARB; DOGS; FIBROBLASTS; FUMARATES; HUMANS; LIGHT; MESENCHYMAL STROMAL CELLS; MICE; MICROSCOPY, FLUORESCENCE; OSTEOBLASTS; POLYETHYLENE; POLYPROPYLENES; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84877786691     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm301962f     Document Type: Article

References (34)

1. Rezwan, K.; Chen, Q.; Blaker, J.; Boccaccini, A. R. Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering Biomaterials 2006, 27, 3413-3431
2. Fisher, J. P.; Dean, D.; Mikos, A. G. Photocrosslinking characteristics and mechanical properties of diethyl fumarate/poly(propylene fumarate) biomaterials Biomaterials 2002, 23, 4333-4343
3. Kim, K.; Dean, D.; Mikos, A. G.; Fisher, J. P. Effect of initial cell seeding density on early osteogenic signal expression of rat bone marrow stromal cells cultured on cross-linked poly(propylene fumarate) disks Biomacromolecules 2009, 10, 1810-1817
4. He, S.; Yaszemski, M. J.; Yasko, A. W.; Engel, P. S.; Mikos, A. G. Injectable biodegradable polymer composites based on poly(propylene fumarate) crosslinked with poly(ethylene glycol)-dimethacrylate Biomaterials 2000, 21, 2389-2394
5. Peter, S. J.; Miller, S. T.; Zhu, G.; Yasko, A. W.; Mikos, A. G. In vivo degradation of a poly(propylene fumarate)/β-tricalcium phosphate injectable composite scaffold J. Biomed. Mater. Res. 1998, 41, 1-7
6. Yaszemski, M. J.; Payne, R. G.; Hayes, W. C.; Langer, R.; Mikos, A. G. In vitro degradation of a poly(propylene fumarate)-based composite material Biomaterials 1996, 17, 2127-2130
7. Timmer, M. D.; Ambrose, C. G.; Mikos, A. G. In vitro degradation of polymeric networks of poly(propylene fumarate) and the crosslinking macromer poly(propylene fumarate)-diacrylate Biomaterials 2003, 24, 571-577
8. Kempen, D. H.; Lu, L.; Hefferan, T. E.; Creemers, L. B.; Maran, A.; Classic, K. L.; Dhert, W. J.; Yaszemski, M. J. Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering Biomaterials 2008, 29, 3245-3252
9. Fisher, J. P.; Holland, T. A.; Dean, D.; Engel, P. S.; Mikos, A. G. Synthesis and properties of photocross-linked poly(propylene fumarate) scaffolds J. Biomater. Sci., Polym. Ed. 2001, 12, 673-687
10. Lewandrowski, K. U.; Bondre, S.; Hile, D. D.; Thompson, B. M.; Wise, D. L.; Tomford, W. W.; Trantolo, D. J. Porous poly(propylene fumarate) foam coating of orthotopic cortical bone grafts for improved osteoconduction Tissue Eng. 2002, 8, 1017-1027
11. Vehof, J. W.; Fisher, J. P.; Dean, D.; van der Waerden, J. P.; Spauwen, P. H.; Mikos, A. G.; Jansen, J. A. Bone formation in transforming growth factor beta-1-coated porous poly(propylene fumarate) scaffolds J. Biomed. Mater. Res. 2002, 60, 241-251
12. Fisher, J. P.; Holland, T. A.; Dean, D.; Mikos, A. G. Photoinitiated cross-linking of the biodegradable polyester poly(propylene fumarate). Part II. In vitro degradation Biomacromolecules 2003, 4, 1335-1342
13. Fisher, J. P.; Vehof, J. W.; Dean, D.; van der Waerden, J. P.; Holland, T. A.; Mikos, A. G.; Jansen, J. A. Soft and hard tissue response to photocrosslinked poly(propylene fumarate) scaffolds in a rabbit model J. Biomed. Mater. Res. 2002, 59, 547-556
14. Timmer, M. D.; Shin, H.; Horch, R. A.; Ambrose, C. G.; Mikos, A. G. In vitro cytotoxicity of injectable and biodegradable poly(propylene fumarate)-based networks: Unreacted macromers, cross-linked networks, and degradation products Biomacromolecules 2003, 4, 1026-1033
15. Kasper, F. K.; Tanahashi, K.; Fisher, J. P.; Mikos, A. G. Synthesis of poly(propylene fumarate) Nat. Protoc. 2009, 4, 518-525
16. Kim, K.; Dean, D.; Lu, A.; Mikos, A. G.; Fisher, J. P. Early osteogenic signal expression of rat bone marrow stromal cells is influenced by both hydroxyapatite nanoparticle content and initial cell seeding density in biodegradable nanocomposite scaffolds Acta Biomater. 2011, 7, 1249-1264
17. Charlesby, A.; Pinner, S.; Pinner, S. Analysis of the solubility behaviour of irradiated polyethylene and other polymers Proc. R. Soc. London, Ser. A 1959, 249, 367-386
18. Yeatts, A. B.; Geibel, E. M.; Fears, F. F.; Fisher, J. P. Human mesenchymal stem cell position within scaffolds influences cell fate during dynamic culture Biotechnol. Bioeng. 2012, 109, 2381-2391
19. Betz, M. W.; Yeatts, A. B.; Richbourg, W. J.; Caccamese, J. F.; Coletti, D. P.; Falco, E. E.; Fisher, J. P. Macroporous hydrogels upregulate osteogenic signal expression and promote bone regeneration Biomacromolecules 2010, 11, 1160-1168
20. Park, J. C.; Park, B. J.; Lee, D. H.; Suh, H.; Kim, D. G.; Kwon, O. H. Evaluation of the cytotoxicity of polyetherurethane (PU) film containing zinc diethyldithiocarbamate (ZDEC) on various cell lines Yonsei Med. J. 2002, 43, 518
21. Tsuchiya, T. Studies on the standardization of cytotoxicity tests and new standard reference materials useful for evaluating the safety of biomaterials J. Biomater. Appl. 1994, 9, 138-157
22. Betz, M. W.; Modi, P. C.; Caccamese, J. F.; Coletti, D. P.; Sauk, J. J.; Fisher, J. P. Cyclic acetal hydrogel system for bone marrow stromal cell encapsulation and osteodifferentiation J. Biomed. Mater. Res. A 2008, 86, 662-670
23. Oliva, A.; Della Ragione, F.; Salerno, A.; Riccio, V.; Tartaro, G.; Cozzolino, A.; D'Amato, S.; Pontoni, G.; Zappia, V. Biocompatibility studies on glass ionomer cements by primary cultures of human osteoblasts Biomaterials 1996, 17, 1351-1356
24. International Organization for Standardization. ISO 10993: Parts 1-12; ISO: Geneva, Switzerland.
25. Chen, J.-P.; Chang, G.-Y.; Chen, J.-K. Electrospun collagen/chitosan nanofibrous membrane as wound dressing Colloids Surf., A 2008, 313-314, 183-188
26. Velayudhan, S.; Anilkumar, T. V.; Kumary, T. V.; Mohanan, P. V.; Fernandez, A. C.; Varma, H. K.; Ramesh, P. Biological evaluation of pliable hydroxyapatite-ethylene vinyl acetate co-polymer composites intended for cranioplasty Acta Biomater. 2005, 1, 201-209
27. La Gatta, A.; De Rosa, A.; Laurienzo, P.; Malinconico, M.; De Rosa, M.; Schiraldi, C. A novel injectable poly(ε-caprolactone)/calcium sulfate system for bone regeneration: Synthesis and characterization Macromol. Biosci. 2005, 5, 1108-1117
28. Timmer, M. D.; Carter, C.; Ambrose, C. G.; Mikos, A. G. Fabrication of poly(propylene fumarate)-based orthopaedic implants by photo-crosslinking through transparent silicone molds Biomaterials 2003, 24, 4707-4714
29. McNaught, A. D.; Wilkinson, A.; International Union of Pure and Applied Chemistry. Compendium of Chemical Terminology: IUPAC Recommendations, 2 nd ed.; Blackwell Science: Oxford, U.K., 1997.
30. Alger, M. S. M. Polymer Science Dictionary; Elsevier Applied Science: London, 1989; pp 69, 94.
31. Tsuchiya, T.; Ikarashi, Y.; Arai, T.; Ohhashi, J.; Isama, K.; Nakamura, A. In vivo tissue/biomaterials toxic responses: Correlation with cytotoxic potential but not cell attachment Clin. Mater. 1994, 16, 1-8
32. Tsuchiya, T.; Ikarashi, Y.; Hata, H.; Toyoda, K.; Takahashi, M.; Uchima, T.; Tanaka, N.; Sasaki, T.; Nakamura, A. Comparative studies of the toxicity of standard reference materials in various cytotoxicity tests and in vivo implantation tests J. Appl. Biomater. 1993, 4, 153-156
33. Yamamoto, A.; Honma, R.; Sumita, M. Cytotoxicity evaluation of 43 metal salts using murine fibroblasts and osteoblastic cells J. Biomed. Mater. Res. 1998, 39, 331-340
34. Kim, K.; Dean, D.; Wallace, J.; Breithaupt, R.; Mikos, A. G.; Fisher, J. P. The influence of stereolithographic scaffold architecture and composition on osteogenic signal expression with rat bone marrow stromal cells Biomaterials 2011, 32, 3750-3763