β-n-methylamino-L-alanine induces changes in both GSK3 and TDP-43 in human neuroblastoma

Journal of Toxicological Sciences

Volumn 38, Issue 3, 2013, Pages 425-430

  Muñoz Saez, Emma ^a   De Munck, Estefanía ^a   Arahuetes, Rosa M ^a   Solas, M Teresa ^a   Martínez, Ana M ^a   Miguel, Begoña G ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Glycogen synthase kinase 3; TAR DNA binding protein; N methylamino L alanine

Indexed keywords

2 AMINO 3 METHYLAMINOPROPIONIC ACID; GLYCOGEN SYNTHASE KINASE 3BETA; TAR DNA BINDING PROTEIN;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; CELL DEATH; CELL FRACTIONATION; CELL VIABILITY; CONTROLLED STUDY; GEL ELECTROPHORESIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNODETECTION; LETTER; MOLECULAR WEIGHT; NEUROBLASTOMA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ISOLATION; TOXICOLOGY; UBIQUITINATION;

EID: 84877778792     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.38.425     Document Type: Letter

References (29)

1. Alley, M.C., Scudiero, D.A., Monks, A., Hursey, M.L., Czerwinski, M.J., Fine, D.L., Abbott, B.J., Mayo, J.G., Shoemaker, R.H. and Boyd, M.R. (1988): Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res., 48, 589-601.
2. Azoulay-Alfaguter, I., Yaffe, Y., Licht-Murava, A., Urbanska, M., Jaworski, J., Pietrokovski, S., Hirschberg, K. and Eldar-Finkelman, H. (2011): Distinct molecular regulation of glycogen synthase kinase-3alpha isozyme controlled by its N-terminal region: functional role in calcium/calpain signaling. J. Biol. Chem., 286, 13470-13480.
3. Balaraman, Y., Limaye, A.R., Levey, A.I. and Srinivasan, S. (2006): Glycogen synthase kinase 3 β and Alzheimer's disease: pathophysiological and therapeutic significance. Cell. Mol. Life Sci., 63, 1226-1235.
4. Beurel, E. and Jope, R.S. (2006): The paradoxical pro- and antiapoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog. Neurobiol., 79, 173-189.
5. Bijur, G.N. and Jope, R.S. (2001): Proapoptotic stimuli induce nuclear accumulation of glycogen synthase kinase-3 beta. J. Biol. Chem., 276, 37436-37442.
6. Brettschneider, J., Van Deerlin, V.M., Robinson, J.L., Kwong, L., Lee, E.B., Ali, Y.O., Safren, N., Monteiro, M.J., Toledo, J.B., Elman, L., McCluskey, L., Irwin, D.J., Grossman, M., Molina-Porcel, L., Lee, V.M. and Trojanowski, J.Q. (2012): Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion. Acta Neuropathol., 123, 825-839.
7. Calcerrada, M.C., Miguel, B.G., Martín, L., Catalán, R.E. and Martínez, A.M.(2002): Involvement of phosphatidylinositol 3-kinase in nuclear translocation of protein kinase C ζ induced by C2-ceramide in rat hepatocytes. FEBS Lett., 514, 361-365.
8. Chiu, A.S., Gehringer, M.M., Braidy, N., Guillemin, G.J., Welch, J.H. and Neilan, B.A. (2012): Excitotoxic potential of the cyanotoxin β-methyl-amino-L-alanine (BMAA) in primary human neurons.Toxicon, 60, 1159-65.
9. Chung, Y.H., Joo, K.M., Kim, D.J., Kim, K.Y., Lee, W.B. and Cha, C.I. (2008): Immunohistochemical study on the distribution of glycogen synthase kinase 3α in the central nervous system of SOD1(G93A) transgenic mice. Neurol. Res., 30, 926-931.
10. Cox, P.A. (2009): Conclusion to the Symposium: the seven pillars of the cyanobacteria/BMAA hypothesis. Amyotroph. Lateral Scler., 10, 124-126.
11. Dunlop, R. and Rodgers, K. (2011): Proteins containing BMAA form autofluorescent aggregates and induce cell death. Amyotrph.Lateral Sclero, 12 Suppl. 1, 156.
12. Holtcamp, W. (2012): The emerging science of BMAA. Environmenthal Healt Perspect., 120, A110-A116.
13. Karamyan, V.T. and Speth, R.C.(2008): Animal models of BMAA neurotoxicity: a critical review. Life Sci., 82, 233-246.
14. Kremer, A., Louis, J.V., Jaworski, T. and Van Leuven, F. (2011): GSK3 and Alzheimer's Disease: Facts and Fiction. Front. Mol. Neurosci., 4, 17-24.
15. Lee, M. and McGeer, P.L. (2012): Weak BMAA toxicity compares with that of the dietary supplement beta-alanine. Neuroiol. Aging, 33, 1440-1447.
16. Lee, V.M., Lee, V.M.Y. and Trojanowski, J.Q. (2011): Gains or losses: molecular mechanisms of TDP 43- mediated neurodegeneration. Nat. Rev. Neurosci., 13, 38-50.
17. Liu-Yesucevitz, L., Bilgutay, A., Zhang, Y.J., Vanderwyde, T., Citro, A., Mehta, T., Zaarur, N., Mckee, A., Bowser, R., Sherman, M., Petrucelli, L. and Wolozin, B. (2010): Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. PloS One, 5, e13250.
18. Meares, G.P. and Jope, R.S. (2007): Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: functional effects in apoptosis. J. Biol. Chem., 282, 19989-17001.
19. Okle, O., Stemmer, K., Deschl, U. and Dietrich, D.R. (2013): L-BMAA induced ER stress and enhanced caspase 12 cleavage in human neuroblastoma SH-SY5Y cells at low non excitotoxic concentrations. Toxicol. Sci., 131, 217-224.
20. Pablo, J., Banack, S.A., Cox, P.A., Jonhson, T.E., Papapetropoulos, S., Bradley, W.G., Buck, A. and Mash D.C. (2009): Cyanobacterial neurotoxin BMAA in ALS and Alzheimer's disease. Acta Neurol. Scand., 120, 216-225.
21. Rodgers, K. and Dunlop, R. (2011): The cyanobacteria-derived BMAA can be incorporated into cell proteins and could thus be an environmental trigger for ALS and other neurological diseases associated with protein misfolding. Amyotrph. Lateral Sclero., 12 Suppl. 1, 22.
22. Ross, S.M., Seelig, M. and Spencer, P.S. (1987): Specific antagonism of excitotoxic action of "uncommon" amino acids assayed in organotypic mouse cortical cultures. Brain Res., 425, 120-127.
23. Sakamaki, J., Daitoku, H., Kaneko, Y., Hagiwara, A. and Fukamizu, A. (2012): GSK3β regulates gluconeogenic gene expression through HNF4α and FOXO1. J. Recept. Signal Transduct. Res., 32, 96-101.
24. Salcedo-Tello, P., Ortiz-Matamoros, A. and Arias, C. (2011): GSK3 function in the brain during development, neuronal plasticity and neurodegeneration. Int. J. Alzheimer Dis., 2011, 189728.
25. Sutherland, C., Leighton, I.A. and Cohen, P. (1993): Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem. J., 296, 15-19.
26. Vance, J.M., Ali, S., Bradley, W.G., Singer, C. and Di Monte, D. (2010): Gene-environment interactions in Parkinson's disease and other forms of parkinsonism. Neurotoxicology, 31, 598-602.
27. Xie, H., Hu, L. and Li, G. (2010): SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease. Chin. Med. J., 123, 1086-1092.
28. Yamamoto, A. and Simonsen, A.(2011): The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration. Neurobiol. Dis., 43, 17-28.
29. Yang, W., Leystra-Lantz, C. and Strong, M.J. (2008): Upregulation of GSK3 β expression in frontal and temporal cortex in ALS with cognitive impairment (ALSci). Brain Res., 1196, 131-139.