Relationship between low free testosterone levels and loss of muscle mass

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Yuki, Atsumu ^a   Otsuka, Rei ^a   Kozakai, Rumi ^b   Kitamura, Itsuko ^c   Okura, Tomohiro ^d   Ando, Fujiko ^e   Shimokata, Hiroshi ^a  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b HOKUSHO UNIVERSITY   (Japan)

^c AICHI GAKUIN UNIVERSITY   (Japan)

^d UNIVERSITY OF TSUKUBA   (Japan)

^e AICHI SHUKUTOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

TESTOSTERONE;

AGING; ARTICLE; BLOOD; BODY MASS; CASE CONTROL STUDY; HISTOLOGY; HUMAN; LONGITUDINAL STUDY; MALE; MIDDLE AGED; ORGAN SIZE; PATHOLOGY; PHYSIOLOGY; RISK FACTOR; SARCOPENIA; SKELETAL MUSCLE;

AGING; BODY MASS INDEX; CASE-CONTROL STUDIES; HUMANS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; MUSCLE, SKELETAL; ORGAN SIZE; RISK FACTORS; SARCOPENIA; TESTOSTERONE;

EID: 84877766685     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep01818     Document Type: Article

References (25)

1. Baumgartner, R. N. et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147, 755-763 (1998). (Pubitemid 28183275)
2. Fried, L. P. et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56, M146-156 (2001). (Pubitemid 32187141)
3. Janssen, I., Heymsfield, S. B. & Ross, R. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 50, 889-896 (2002). (Pubitemid 34496687)
4. Cruz-Jentoft, A. J. et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39, 412-423 (2010).
5. Baumgartner, R. N., Waters, D. L., Gallagher, D., Morley, J. E. & Garry, P. J. Predictors of skeletal muscle mass in elderly men and women. Mech Ageing Dev 107, 123-136 (1999). (Pubitemid 29138849)
6. Szulc, P., Duboeuf, F., Marchand, F. & Delmas, P. D. Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: theMINOS study.Am J Clin Nutr 80, 496-503 (2004).
7. Smith, M. R. et al. Changes in body composition during androgen deprivation therapy for prostate cancer. J Clin Endocrinol Metab 87, 599-603 (2002). (Pubitemid 34158224)
8. LeBlanc, E. S. et al. Higher testosterone levels are associated with less loss of lean body mass in older men. J Clin Endocrinol Metab 96, 3855-3863 (2011).
9. Sanada, K. et al. A cross-sectional study of sarcopenia in Japanese men and women: reference values and association with cardiovascular risk factors. Eur J Appl Physiol 110, 57-65 (2010).
10. Ponholzer, A. et al. Relationship between testosterone serum levels and lifestyle in aging men. Aging Male 8, 190-193 (2005). (Pubitemid 43068311)
11. Sancini, A. et al. Exposure to urban stressors and free testosterone plasma values. Int Arch Occup Environ Health 84, 609-616 (2010).
12. Wu, A. H. et al. Serum androgens and sex hormone-binding Globulins in relation to lifestyle factors in older African-American, white, and Asian men in the United States and Canada. Cancer Epidemiol Biomarkers Prev 4, 735-741 (1995).
13. Demling, R. H. & Orgill, D. P. The anticatabolic and wound healing effects of the testosterone analog oxandrolone after severe burn injury. J Crit Care 15, 12-17 (2000). (Pubitemid 30167770)
14. Mauras, N. et al. Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength, and adiposity. J Clin Endocrinol Metab 83, 1886-1892 (1998). (Pubitemid 28496311)
15. Sinha-Hikim, I., Cornford, M., Gaytan, H., Lee, M. L. & Bhasin, S. Effects of testosterone supplementation on skeletal muscle fiber hypertrophy and satellite cells in community-dwelling older men. J Clin Endocrinol Metab 91, 3024-3033 (2006). (Pubitemid 44271751)
16. Feldman, H. A. et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. J Clin Endocrinol Metab 87, 589-598 (2002). (Pubitemid 34158223)
17. Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J. & Blackman, M. R. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab 86, 724-731 (2001). (Pubitemid 32207487)
18. Yasui, T. et al. Associations of endogenous sex hormones and sex hormonebinding globulin with lipid profiles in aged Japanese men and women. Clin Chim Acta 398, 43-47 (2008).
19. Gower, B. A. & Nyman, L. Associations among oral estrogen use, free testosterone concentration, and lean body mass among postmenopausal women. J Clin Endocrinol Metab 85, 4476-4480 (2000). (Pubitemid 32157621)
20. Shimokata, H., Ando, F. & Niino, N. A new comprehensive study on aging-the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). J Epidemiol 10, S1-9 (2000).
21. Iwamoto, T., Yanase, T., Horie, H., Namiki, M. & Okuyama, A. Late-onset hypogonadism (LOH) and androgens: validity of the measurement of free testosterone levels in the diagnostic criteria in Japan. Int J Urol 16, 168-174 (2009).
22. Okamura, K., Ando, F. & Shimokata, H. Serum total and free testosterone level of Japanese men: a population-based study. Int J Urol 12, 810-814 (2005). (Pubitemid 41726976)
23. Vermeulen, A., Verdonck, L. & Kaufman, J. M. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 84, 3666-3672 (1999). (Pubitemid 30645223)
24. Kozakai, R., Ando, F., Kim, H. Y., Rantanen, T. & Shimokata, H. Regular exercise history as a predictor of exercise in community-dwelling older Japanese people. J Physical Fitness and Sports Medicine 1, 167-174 (2012).
25. Imai, T. et al. Advantages of takeing photographs with the 3-day dietary record. J Integrated Study of Dietary Habits 20, 203-210 (2009).