Late-onset hypogonadism (LOH) and androgens: Validity of the measurement of free testosterone levels in the diagnostic criteria in Japan: Review Article

International Journal of Urology

Volumn 16, Issue 2, 2009, Pages 168-174

  Iwamoto, Teruaki ^a   Yanase, Toshihiko ^b   Horie, Hitoshi ^c   Namiki, Mikio ^d   Okuyama, Akihiko ^e  

^a INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c LSI MEDIENCE CORPORATION   (Japan)

^d KANAZAWA UNIV SCHOOL OF MEDICINE   (Japan)

^e OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Free testosterone; Total testosterone; Young adult mean (YAM)

Indexed keywords

ANDROGEN; PROTEIN; TESTOSTERONE;

AGING; ANDROGEN BLOOD LEVEL; BIOAVAILABILITY; BLOOD; BLOOD SAMPLING; CLINICAL RESEARCH; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; GONAD FUNCTION; GROUPS BY AGE; HUMAN; HYPOGONADISM; JAPAN; JAPANESE; MEDICAL SOCIETY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REVIEW; TESTOSTERONE BLOOD LEVEL;

AGE FACTORS; ANDROGENS; HUMANS; HYPOGONADISM; JAPAN; MALE; REFERENCE STANDARDS; REFERENCE VALUES; TESTOSTERONE;

EID: 60349130914     PISSN: 09198172     EISSN: 14422042     Source Type: Journal    
DOI: 10.1111/j.1442-2042.2008.02203.x     Document Type: Review

References (30)

1. Nieshlag E, Swerdloff R, Behre HM et al. Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. J. Androl. 2006 27 : 135 7.
2. Nieshlag E, Swerdloff R, Behre HM et al. International Society of Andrology (ISA); International Society for the Study of the Aging Male (ISSAM); European Association of Urology (EAU): Investigation, treatment, and monitoring of late-onset hypogonadism in males. ISA, ISSAM, and EAU recommendations. Eur. Urol. 2005 48 : 1 47.
3. Nieshlag E, Swerdloff R, Behre HM et al. Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, and EAU recommendations. Int. J. Androl. 2005 28 : 125 7.
4. Schiavi RC, Schreiner-Engel P, White D et al. The relationship between pituitary-gonadal function and sexual behavior in healthy aging men. Psychosom. Med. 1991 53 : 363 74.
5. Wang C, Swedloff RS, Nieschlag E et al. International Society for the study of the Aging Male Conference, in Tampa, FL 2008.
6. Namiki M, Akaza H, Shimazui T et al. Clinical practice manual for late-onset hypogonadism syndrome. Int. J. Urol. 2008 15 : 377 88.
7. James F, Dunn C, Nisula B et al. Transport of steroid hormones: Binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J. Clin. Endocrinol. Metab. 1981 53 : 58 68.
8. Manni A, Pardridge WM, Cefalu W et al. Bioavailability of Albumin-Bound Testosterone. J. Clin. Endocrinol. Metab. 1985 61 : 705 10.
9. Cumming DC, Wall SR. Non-sex hormone-binding globulin-bound testosterone as a marker for hyperandrogenism. J. Clin. Endocrinol. Metab. 1985 61 : 873 6.
10. Soudergard R, Bauckstroum T, Shanbhag V et al. Calculation of free and bound fractions of testosterone and estradiol-17β to human plasma proteins at body temperature. J. steroid Biochem. 1982 16 : 801 10.
11. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in Serum. J. Clin. Endocrinol. Metab. 1999 84 : 3666 72.
12. Namiki M, Koh E, Takashima M. [Aging and androgen.] Hinyokigeka 2003 16 : 825 30 in Japanese).
13. Matsuda T, Tatsumi K. Diagnosis and therapy of late-onset hypogonadism Hinyokigeka 2003 16 : 831 7 in Japanese).
14. Purifoy FE, Koopmans LH, Mayes DM. Age differences in serum androgen levels in normal adult males. Hum. Biol. 1981 53 : 499 511.
15. Morley JE, Kaiser FE, Perry HM 3rd. et al. Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism 1997 46 : 410 13.
16. Zmuda JM, Cauley JA, Kriska A et al. Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men. A 13-year follow-up of former Multiple Risk Factor Intervention Trial participants. AM. J. Epidemiol. 1997 146 : 609 17.
17. Harman SM, Metter EJ, Tobin JD et al. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J. Clin. Endocrinol. Metab. 2001 86 : 724 31.
18. Feldman HA, Longcope C, Derby CA et al. Age trends in the level of serum testosterone and other hormones in middle-aged men: Longitudinal results from the Massachusetts male aging study. J. Clin. Endocrinol. Metab. 2002 87 : 589 98.
19. Jensen TK, Andersson AM, Hjollund NH et al. Inhibin B as a serum marker of spermatogenesis: Correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men. J. Clin. Endocrinol. Metab. 1997 82 : 4059 63.
20. Iwamoto T, Yanase T, Koh E et al. [Reference ranges of total testosterone and free testosterone in Japanese male adults.] Nippon Hinyokika Gakkai Zasshi 2005 95 : 751 60 in Japanese)
21. Boots LR, Potter S, Potter D et al. Measurement of total serum testosterone levels using commercially available kits: High degree of between-kit variability. Fertil Steril. 1998 69 : 286 92.
22. El Shami AS. Patent Bulletin in Japan No.2575338 A Said EL Shami 1985
23. Ooi DS, Innanen VT, Wang D et al. Establishing reference intervals for DPC's free testosterone radioimmunoassay. Clin. Biochem. 1998 31 : 115 21.
24. Sato Y, Kato S, Oonishi S et al. [Analysis of subjective symptoms and endocrine findings in male patients at PADAM clinics.] Nippon Hinyokika Gakkai Zasshi. 2004 95 : 8 16 in Japanese).
25. Orimo H, Sugioka Y, Tominaga H et al. (Working Committee on diagnostic guidelines for Osteoporosis in The Japanese Society for Bone and Mineral Research). Diagnostic standard of primary osteoporosis (1966 revised ed.) J. Bone Miner. Metab. 1997 14 : 219 33.
26. Orimo H, Hayashi Y, Tominaga H et al. (Working Committee on diagnostic guidelines for Osteoporosis in The Japanese Society for Bone and Mineral Research). Diagnostic standard of primary osteoporosis (2000 revised ed.) J. Bone Miner. Metab. 2001 18 : 76 82.
27. Endocrine Society : Summary from the second andropause consensus committee, 2002.
28. Lunenfeld B, Saad F, Hoesl CE. ISA, ISSAM and EAU recommendations for the investigation, treatment and monitoring of late-onset hypogonadism in males: Scientific background and rationale. Aging Male 2005 8 : 59 74. Review.
29. Hong SK, Han BK, Jeong JS et al. Serum measurements of testosterone, insulin-like growth factor 1, and insulin-like growth factor binding protein-3 in the diagnosis of prostate cancer among Korean men. Asian J. Androl. 2008 10 : 207 13.
30. Martinez-Jabaloyas JM, Queipo-Zaragoza A et al. Evaluation of an immunoassay kit to measure free testosterone. Actas Urol. Esp. 2006 598 601.