Systems pharmacology modeling of drug-induced modulation of thyroid hormones in dogs and translation to human

Pharmaceutical Research

Volumn 30, Issue 6, 2013, Pages 1513-1524

  Ekerot, Petra ^a   Ferguson, Douglas ^b   Glämsta, Eva Lena ^a   Nilsson, Lars B ^c   Andersson, Håkan ^a   Rosqvist, Susanne ^a   Visser, Sandra A G ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b Modeling and Simulation   (United States)

^c Regulatory Bioanalysis   (Sweden)

Author keywords

inter species extrapolation; pharmacokinetics and pharmacodynamics; T 3; T4; Thyroperoxidase; TSH

Indexed keywords

LIOTHYRONINE; MYELOPEROXIDASE; THYROID PEROXIDASE; THYROTROPIN; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOG; ENZYME INHIBITION; FEMALE; HOMEOSTASIS; HORMONE BLOOD LEVEL; HORMONE METABOLISM; HUMAN; IC 50; IN VITRO STUDY; LIMIT OF QUANTITATION; LOWER LIMIT OF QUANTIFICATION; MALE; MATHEMATICAL MODEL; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; SYSTEMS PHARMACOLOGY MODEL; TURNOVER TIME;

ANIMALS; DOGS; ENZYME INHIBITORS; FEMALE; HUMANS; MALE; MODELS, BIOLOGICAL; PEROXIDASE; THYROID GLAND; THYROTROPIN; THYROXINE; TRIIODOTHYRONINE;

EID: 84877764759     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-0989-4     Document Type: Article

References (36)

1. Guyton AC, Hall JE. Textbook of medicial physiology. Eleventhth ed. Philadelphia: Elsevier Inc; 2006.
2. Zoeller RT, Tan SW, Tyl RW. General Background on the Hypothalamic-Pituitary-Thyroid (HPT) Axis. Crit Rev Toxicol 2007 01/01; 2012/08;37(1, 2):11-53.
3. Jameson JL, Weetman AP. Disorders of the thyroid gland. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, Longo DL, Jameson JL, editors. Harrison's Principles of Internal Medicine, 15th Edition: McGraw-Hill Companies, Inc; 2001. p. 2060-2064.
4. Fliers E, Alkemade A, Wiersinga WM, Swaab DF. Hypothalamic thyroid hormone feedback in health and disease. In: Kalsbeek, Fliers E, Hofman, Swaab, Van Someren, Buys, editors. Progress in Brain Research: Elsevier; 2006. p. 189-207.
5. Ridgway EC, Weintraub BD, Maloof F. Metabolic clearance and production rates of human thyrotropin. J Clin Invest. 1974;53(3):895-903.
6. Nussey S, Whitehead S. An integrated Approach. Oxford: Bios Scientific Publishers. 2001.
7. McGuire RA, Hays MT. A kinetic model of human thyroid hormones and their conversion products. J Clin Endocrinol Metab. 1981;53(4):852-62.
8. Belshaw BE, Barandes M, Becker DV, Berman M. A model of iodine kinetics in the dog. Endocrinology. 1974;95(4):1078-93.
9. Kaptein EM, Moore GE, Ferguson DC, Hoenig M. Thyroxine and triiodothyronine distribution and metabolism in thyroxine-replaced athyreotic dogs and normal humans. Am J Physiol. 1993;264(1 Pt 1):E90-E100.
10. van der Graaf PH, Benson N. Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development. Pharm Res. 2011;28(7):1460-4.
11. Degon M, Chipkin SR, Hollot CV, Zoeller RT, Chait Y. A computational model of the human thyroid. Math Biosci. 2008;212(1):22-53.
12. Hatakeyama T, Yagi H. Computer simulation for hormones related to primary thyropathy. Biol Cybern. 1985;52(4):259-66.
13. Saratchandran P, Carson ER, Reeve J. An improved mathematical model of human thyroid hormone regulation. Clin Endocrinol (Oxf). 1976;5(5):473-83.
14. DiStefano 3rd JJ, Stear EB. On identification of hypothalamo-hypophysial control and feedback relationships with the thyroid gland. J Theor Biol. 1968;19(1):29-50.
15. Danziger L, Elmergreen G. Mathematical models of endocrine systems. Bull Math Biol. 1957;19(1):9-18.
16. Hays MT, Broome MR, Turrel JM. A multicompartmental model for iodide, thyroxine, and triiodothyronine metabolism in normal and spontaneously hyperthyroid cats. Endocrinology. 1988;122(6):2444-61.
17. McLanahan ED, Andersen ME, Fisher JW. A biologically based dose-response model for dietary iodide and the hypothalamic-pituitary-thyroid axis in the adult rat: evaluation of iodide deficiency. Toxicol Sci. 2008;102(2):241-53.
18. Merrill EA, Clewell RA, Robinson PJ, Jarabek AM, Gearhart JM, Sterner TR, et al. PBPK model for radioactive iodide and perchlorate kinetics and perchlorate-induced inhibition of iodide uptake in humans. Toxicol Sci. 2005;83(1):25-43.
19. Eisenberg M, Samuels M, DiStefano 3rd JJ. Extensions, validation, and clinical applications of a feedback control system simulator of the hypothalamo-pituitary-thyroid axis. Thyroid. 2008;18(10):1071-85.
20. Eisenberg M, Samuels M, DiStefano 3rd JJ. L-T4 bioequivalence and hormone replacement studies via feedback control simulations. Thyroid. 2006;16(12):1279-92.
21. Eisenberg MC, Santini F, Marsili A, Pinchera A, DiStefano 3rd JJ. TSH regulation dynamics in central and extreme primary hypothyroidism. Thyroid. 2010;20(11):1215-28.
22. Mukhopadhyay B, Bhattacharyya R. A mathematical model describing the thyroid-pituitary axis with time delays in hormone transportation. Appl Math. 2006;6:549-64.
23. Dietrich JW, Boehm BO. Equilibrium behaviour of feedback-coupled physiological saturation kinetics. Cybern Syst. 2006;1:269-74.
24. Dietrich JW, Tesche A, Pickardt CR, Mitzdorf U. Thyrotropic feedback control: evidence of an additional ultrashort feedback loop from fractal analysis. Cybern Syst 2004 06/01; 2012/08;35(4):315-331.
25. Kimura S, Ikeda-Saito M. Human myeloperoxidase and thyroid peroxidase, two enzymes with separate and distinct physiological functions, are evolutionarily related members of the same gene family. Proteins. 1988;3(2):113-20.
26. Malle E, Furtmüller PG, Sattler W, Obinger C. Myeloperoxidase: a target for new drug development? Br J Pharmacol. 2007;152(6):838-54.
27. Nilsson LB, Eklund G. Direct quantification in bioanalytical LC-MS/MS using internal calibration via analyte/stable isotope ratio. J Pharm Biomed Anal. 2007;43(3):1094-9.
28. Savic RM, Jonker DM, Kerbusch T, Karlsson MO. Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies. J Pharmacokinet Pharmacodyn. 2007;34(5):711-26.
29. 3 kinetics following thyroidectomy and effect of replacement therapy in the canine. Fed Proc 1980;39:947.
30. Kinlaw WB, Schwartz HL, Oppenheimer JH. Decreased serum triiodothyronine in starving rats is due primarily to diminished thyroidal secretion of thyroxine. J Clin Invest. 1985;75(4):1238-41.
31. Nicoloff JT, Low JC, Dussault JH, Fisher DA. Simultaneous measurement of thyroxine and triiodothyronine peripheral turnover kinetics in man. J Clin Invest. 1972;51(3):473-83.
32. Spencer CA, Hollowell JG, Kazarosyan M, Braverman LE. National health and nutrition examination survey III thyroid-stimulating hormone (TSH)-thyroperoxidase antibody relationships demonstrate that TSH upper reference limits may be skewed by occult thyroid dysfunction. J Clin Endocrinol Metab. 2007;92(11):4236-40.
33. Liu Y, Liu B, Xie J, Liu YX. A new mathematical model of hypothalamo-pituitary-thyroid axis. Math Comput Model. 1994;19(9):81-90.
34. Li G, Liu B, Liu Y. A dynamical model of the pulsatile secretion of the hypothalamo-pituitary-thyroid axis. Biosystems. 1995;35(1):83-92.
35. Hays MT, McGuire RA. Distribution of subcutaneous thyroxine, triiodothyronine, and albumin in man: comparison with intravenous administration using a kinetic model. J Clin Endocrinol Metab. 1980;51(5):1112-7.
36. Kaplan MM. The role of thyroid hormone deiodination in the regulation of hypothalamo-pituitary function. Neuroendocrinology. 1984;38(3):254-60.