Prospective study of restless legs syndrome and risk of erectile dysfunction

American Journal of Epidemiology

Volumn 177, Issue 10, 2013, Pages 1097-1105

  Li, Yanping ^a   Batool Anwar, Salma ^a   Kim, Sehee ^a   Rimm, Eric B ^a   Ascherio, Alberto ^a   Gao, Xiang ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

erectile dysfunction; prospective studies; restless legs syndrome; sleep disorders

Indexed keywords

DISEASE INCIDENCE; DISEASE PREVALENCE; DISEASE TREATMENT; HEALTH RISK; QUESTIONNAIRE SURVEY; SLEEP; SYMPTOM;

ADULT; BODY MASS; DISEASE ASSOCIATION; ERECTILE DYSFUNCTION; HIGH RISK PATIENT; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; PHYSICAL ACTIVITY; PROSPECTIVE STUDY; QUESTIONNAIRE; RESTLESS LEGS SYNDROME; REVIEW; RISK ASSESSMENT; SLEEP DISORDER; SMOKING; SNORING;

ERECTILE DYSFUNCTION; PROSPECTIVE STUDIES; RESTLESS LEGS SYNDROME; SLEEP DISORDERS;

ADULT; AGED; ERECTILE DYSFUNCTION; HEALTH PERSONNEL; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RESTLESS LEGS SYNDROME; RISK FACTORS; UNITED STATES;

UNITED STATES;

EID: 84877764222     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kws364     Document Type: Review

References (49)

1. Bacon CG, Mittleman MA, Kawachi I, et al. Sexual function in men older than 50 years of age: Results from the Health Professionals Follow-up Study. Ann Intern Med. 2003; 139(3):161-168
2. Blanker MH, Bosch JL, Groeneveld FP, et al. Erectile and ejaculatory dysfunction in a community-based sample of men 50 to 78 years old: Prevalence, concern, and relation to sexual activity. Urology. 2001;57(4):763-768
3. Panser LA, Rhodes T, Girman CJ, et al. Sexual function of men ages 40 to 79 years: The Olmsted County Study of Urinary Symptoms and Health Status Among Men. J Am Geriatr Soc. 1995;43(10):1107-1111
4. Argiolas A, Melis MR. Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus. Prog Neurobiol. 2005;76(1):1-21
5. Andersson KE. Pharmacology of penile erection. Pharmacol Rev. 2001;53(3):417-450
6. Andersson KE. Mechanisms of penile erection and basis for pharmacological treatment of erectile dysfunction. Pharmacol Rev. 2011;63(4):811-859
7. Gao X, Schwarzschild MA, O'Reilly EJ, et al. Restless legs syndrome and erectile dysfunction. Sleep. 2010;33(1): 75-79
8. Ulfberg J, Nyström B, Carter N, et al. Prevalence of restless legs syndrome among men aged 18 to 64 years: An association with somatic disease and neuropsychiatric symptoms. Mov Disord. 2001;16(6):1159-1163
9. Rothdach AJ, Trenkwalder C, Haberstock J, et al. Prevalence and risk factors of RLS in an elderly population: The MEMO. Memory and Morbidity in Augsburg Elderly study. Neurology. 2000;54(5):1064-1068
10. Berger K, Luedemann J, Trenkwalder C, et al. Sex and risk of restless legs syndrome in the general population. Arch Intern Med. 2004;164(2):196-202
11. Scholz H, Trenkwalder C, Kohnen R, et al. Dopamine agonists for restless legs syndrome. Cochrane Database Syst Rev. 2011;3:CD006009
12. Cikrikcioglu MA, Hursitoglu M, Erkal H, et al. Oxidative stress and autonomic nervous system functions in restless legs syndrome. Eur J Clin Invest. 2011;41(7):734-742
13. Hull EM, Muschamp JW, Sato S. Dopamine and serotonin: Influences on male sexual behavior. Physiol Behav. 2004; 83(2):291-307
14. Walters AS, Rye DB. Review of the relationship of restless legs syndrome and periodic limb movements in sleep to hypertension, heart disease, and stroke. Sleep. 2009;32(5): 589-597
15. de Groat WC, Booth AM. Neural control of penile erection. In: Maggi CA, ed. Nervous Control of the Urogenital System. (The Autonomic Nervous System, vol 3). London, United Kingdom: Harwood Academic Publishers; 1993:465-513
16. Phillips B, Young T, Finn L, et al. Epidemiology of restless legs symptoms in adults. Arch Intern Med. 2000;160(14): 2137-2141
17. Allen RP, Picchietti D, HeningWA, et al. Restless legs syndrome: Diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4(2):101-119
18. National Institutes of Health. Impotence. NIH Consens Statement. 1992;10(4):1-33
19. Lewis RW, Fugl-Meyer KS, Bosch R, et al. Definitions, classification, and epidemiology of sexual dysfunction. In: Lue TF, Basson R, Rosen RC, et al, eds. Sexual Medicine. Paris, France: Health Publications; 2004:37-72
20. Jenkins CD, Stanton BA, Niemcryk SJ, et al. A scale for the estimation of sleep problems in clinical research. J Clin Epidemiol. 1988;41(4):313-321
21. Platz EA, Kawachi I, Rimm EB, et al. Physical activity and benign prostatic hyperplasia. Arch Intern Med. 1998;158(21): 2349-2356
22. Kawachi I, Colditz GA, Ascherio A, et al. Prospective study of phobic anxiety and risk of coronary heart disease in men. Circulation. 1994;89(5):1992-1997
23. Barry MJ, Fowler FJ Jr, O'Leary MP, et al. The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association. J Urol. 1992;148(5): 1549-1557
24. Wolf AM, Hunter DJ, Colditz GA, et al. Reproducibility and validity of a self-Administered physical activity questionnaire. Int J Epidemiol. 1994;23(5):991-999
25. Greenland S. Model-based estimation of relative risks and other epidemiologic measures in studies of common outcomes and in case-control studies. Am J Epidemiol. 2004;160(4): 301-305
26. Zou G. A modified Poisson regression approach to prospective studies with binary data. Am J Epidemiol. 2004;159(7): 702-706
27. Sikandar R, Khealani BA,Wasay M. Predictors of restless legs syndrome in pregnancy: A hospital based cross sectional survey from Pakistan. Sleep Med. 2009;10(6):676-678
28. O'Keeffe ST, Gavin K, Lavan JN. Iron status and restless legs syndrome in the elderly. Age Ageing. 1994;23(3): 200-203
29. HeningWA, Allen RP,Washburn M, et al. The four diagnostic criteria for restless legs syndrome are unable to exclude confounding conditions ('mimics'). Sleep Med. 2009;10(9): 976-981
30. Allen RP,Walters AS, Montplaisir J, et al. Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med. 2005;165(11):1286-1292
31. Zias N, Bezwada V, Gilman S, et al. Obstructive sleep apnea and erectile dysfunction: Still a neglected risk factor? Sleep Breath. 2009;13(1):3-10
32. Karacan I, Karatas M. Erectile dysfunction in sleep apnea and response to CPAP. J Sex Marital Ther. 1995;21(4): 239-247
33. Margel D, Tal R, Livne PM, et al. Predictors of erectile function improvement in obstructive sleep apnea patients with long-term CPAP treatment. Int J Impot Res. 2005;17(2): 186-190
34. Taskin U, Yigit O, Acioglu E, et al. Erectile dysfunction in severe sleep apnea patients and response to CPAP. Int J Impot Res. 2010;22(2):134-139
35. Melis MR. Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus. Prog Neurobiol. 2005;76(1):1-21
36. PaulusW, Dowling P, Rijsman R, et al. Pathophysiological concepts of restless legs syndrome. Mov Disord. 2007; 22(10):1451-1456
37. Mann K, Pankok J, Connemann B, et al. Sleep investigations in erectile dysfunction. J Psychiatr Res. 2005;39(1):93-99
38. Salin-Pascual R, Gerashchenko D, Greco MA, et al. Hypothalamic regulation of sleep. Neuropsychopharmacology. 2001;25(5 suppl):S21-S27
39. Yeh P,Walters AS, Tsuang JW. Restless legs syndrome: A comprehensive overview on its epidemiology, risk factors, and treatment. Sleep Breath. 2012;16(4):987-1007
40. Clemens S, Rye D, Hochman S. Restless legs syndrome: Revisiting the dopamine hypothesis from the spinal cord perspective. Neurology. 2006;67(1):125-130
41. Rees PM, Fowler CJ, Maas CP. Sexual function in men and women with neurological disorders. Lancet. 2007;369(9560): 512-525
42. Hirshkowitz M, Karacan I, Arcasoy MO, et al. The prevalence of periodic limb movements during sleep in men with erectile dysfunction. Biol Psychiatry. 1989;26(6):541-544
43. Picchietti D,Winkelman JW. Restless legs syndrome, periodic limb movements in sleep, and depression. Sleep. 2005;28(7): 891-898
44. Nomura T, Inoue Y, Kusumi M, et al. Prevalence of restless legs syndrome in a rural community in Japan. Mov Disord. 2008;23(16):2363-2369
45. Celle S, Roche F, Kerleroux J, et al. Prevalence and clinical correlates of restless legs syndrome in an elderly French population: The Synapse Study. J Gerontol A Biol Sci Med Sci. 2010;65(2):167-173
46. Gao X, Schwarzschild MA,Wang H, et al. Obesity and restless legs syndrome in men and women. Neurology. 2009;72(14):1255-1261
47. O'Donnell AB, Araujo AB, Goldstein I, et al. The validity of a single-question self-report of erectile dysfunction. Results from the Massachusetts Male Aging Study. J Gen Intern Med. 2005;20(6):515-519
48. Bliwise DL, Nekich JC, Dement WC. Relative validity of selfreported snoring as a symptom of sleep apnea in a sleep clinic population. Chest. 1991;99(3):600-608
49. Ketterer MW, Brymer J, Rhoads K, et al. Snoring and the severity of coronary artery disease in men. Psychosom Med. 1994;56(3):232-236