Adult onset nesidioblastosis treated by subtotal pancreatectomy

Journal of the Pancreas

Volumn 14, Issue 3, 2013, Pages 286-288

  Gupta, Rahul Amreesh ^a   Patel, Roma Prahladbhai ^a   Nagral, Sanjay ^a  

^a JASLOK HOSPITAL AND RESEARCH CENTRE   (India)

Author keywords

Hypoglycemia; Insulinoma; Nesidioblastosis; Pancreatectomy

Indexed keywords

C PEPTIDE; DIAZOXIDE; GLUCOSE; INSULIN;

ADULT; ARTICLE; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; DIAGNOSTIC ERROR; DIZZINESS; DRUG TREATMENT FAILURE; FEMALE; HISTOPATHOLOGY; HUMAN; HYPERINSULINEMIA; HYPOGLYCEMIA; IMMUNOHISTOCHEMISTRY; INSULINOMA; LAPAROTOMY; NUCLEAR MAGNETIC RESONANCE IMAGING; PANCREAS RESECTION; PEROPERATIVE ECHOGRAPHY; PREOPERATIVE EVALUATION; REOPERATION; SPLENECTOMY; SUGAR INTAKE; TREATMENT OUTCOME; TUMOR VOLUME; UNCONSCIOUSNESS;

C-PEPTIDE; DIAGNOSIS, DIFFERENTIAL; DIAGNOSTIC ERRORS; FEMALE; HUMANS; HYPOGLYCEMIA; INSULIN; INSULINOMA; ISLETS OF LANGERHANS; MIDDLE AGED; NESIDIOBLASTOSIS; PANCREATECTOMY; PANCREATIC NEOPLASMS;

EID: 84877752161     PISSN: 15908577     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Laidlaw GF. Nesidioblastoma, the islet cell tumor of the pancreas. Am J Pathol 1938; 14: 125-134.
2. Witteles RM, Straus II FH, Sugg SL, Koka MR, Costa EA, Kaplan EL. Adult-onset nesidioblastosis causing hypoglycemia: an important clinical entity and continuing treatment dilemma. Arch Surg 2001; 136: 656-663.
3. Qintar M, Sibai F, Taha M. Hypoglycemia due to adult onset nesidioblastosis, a diagnostic and management dileema. Avicenna J Med 2012;2:45-7
4. Service FJ, Natt N, Thompson GB, Grant CS, van Heerden JA, Andrews JC, et al. Noninsulinoma pancreatogenous hypoglycemia: a novel syndrome of hyperinsulinemic hypoglycemia in adults independent of mutations in Kir6.2 and SUR1 genes. J Clin Endocrinol Metab 1999; 84:1582-9.
5. Cryer PE, Axelrod L, Grossman AB, Heller SR, Montori VM, Seaquist ER, et al. Evaluation and management of adult hypoglycemic disorders: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2009; 94:709.
6. Doppman JL, Chang R, Fraker DL, Norton JA; Alexander HR, Miller DL, et al. Localization of insulinomas to regions of the pancreas by intra-arterial stimulation with calcium. Ann Intern Med 1995; 123:269.
7. Kauhanen S, Seppanen M, Minn H, Gullichsen R, Salonen A, Alanen K, et al. Fluorine-18-L-Dihydroxyphenylalanine (18F-DOPA) Positron Emission Tomography as a Tool to Localize an Insulinoma or Cell Hyperplasia in Adult Patients. J Clin Endocrinol Metab 2007;92(4):1237-1244
8. Raffel A, Anlauf M, Hosch SB, Krausch M, Henopp T, Bauersfeld J, et al. Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes. World J Gastroenterol 2006; 12(44): 7221-7224.
9. Bright E, Garcea G, Ong SL, Madira W, Berry DP, Dennison AR. An Unusual Case of Concurrent Insulinoma and Nesidioblastosis. J Pancreas (Online) 2008; 9(5):649-653.
10. Heitz PU, Kloppel G, Hacki WH, Polak JM, Pearse AG. Nesidioblastosis: the pathologic basis of persistent hyperinsulinemic hypoglycemia in infants. Morphologic and quantitative analysis of seven cases based on specific immunostaining and electron microscopy. Diabetes 1977; 26: 632-642
11. Goossens A, Gepts W, Saudubray JM, Bonnefont JP, Nihoul-Fekete, Heitz PU, Kloppel G. Diffuse and focal nesidioblastosis. A clinicopathological study of 24 patients with persistent neonatal hyperinsulinemic hypoglycemia. Am J Surg Pathol 1989; 13:766-775
12. Arao T, Okada Y, Hirose A, Tanaka Y. A rare case of adult onset nesidioblastosis treated successfully with diazoxide. Endocr J 2006; 53: 95-100
13. Spanakis E, Gragnoli C. Successful medical management of status post-Roux-en-Y-gastric-bypass hyperinsulinemic hypoglycemia. Obes Surg 2009; 19:1333.
14. Draman MS, Ahern T, Smith T, O'Shea D. Selective intra-arterial calcium stimulation with hepatic venous sampling in investigation of hyperinsulinemic hypoglycemia. Ir J Med Sci 2006; 175(Suppl. 2):42.