A high-throughput method for measurement of glomerular filtration rate in conscious mice

Journal of Visualized Experiments

Volumn , Issue 75, 2013, Pages

  Rieg, Timo ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Anatomy; Animal model; Biomedical engineering; Conscious; Creatinine; Glomerular filtration rate; HPLC; Hypertension; Inulin; Issue 75; Jaffe; Kidney function tests; Medicine; Mice; Molecular biology; Nephrology; Physiology; Rats

Indexed keywords

DIAGNOSTIC AGENT; DRUG DERIVATIVE; FLUORESCEIN ISOTHIOCYANATE; FLUORESCENT DYE; INSULIN; INSULIN, FLUORESCEIN ISOTHIOCYANATED; INSULIN, FLUORESCEIN-ISOTHIOCYANATED-;

ANIMAL; ARTICLE; BLOOD; CONSCIOUSNESS; GLOMERULUS FILTRATION RATE; HIGH THROUGHPUT SCREENING; INTRAVENOUS DRUG ADMINISTRATION; KIDNEY FUNCTION TEST; METHODOLOGY; MOUSE; PHYSIOLOGY;

ANIMALS; CONSCIOUSNESS; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; GLOMERULAR FILTRATION RATE; HIGH-THROUGHPUT SCREENING ASSAYS; INJECTIONS, INTRAVENOUS; INSULIN; KIDNEY FUNCTION TESTS; MICE;

EID: 84877737740     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/50330     Document Type: Article

References (23)

1. Bauer, J.H., Brooks, C.S., & Burch, R.N. Clinical appraisal of creatinine clearance as a measurement of glomerular filtration rate. Am. J. Kidney Dis. 2 (3), 337-346 (1982).
2. Carrie, B.J., Golbetz, H.V., Michaels, A.S., & Myers, B.D. Creatinine: an inadequate filtration marker in glomerular diseases. Am. J. Med. 69 (2), 177-182 (1980).
3. Chasis, H., Ranges, H.A., Goldring, W., & Smith, H.W. The Control of Renal Blood Flow and Glomerular Filtration in Normal Man. J. Clin. Invest. 17 (5), 683-697 (1938).
4. Darling, I.M. & Morris, M.E. Evaluation of true creatinine clearance in rats reveals extensive renal secretion. Pharm. Res. 8 (10), 1318-1322 (1991). http://www.nanodrop.com/Productnd3300overview.aspx, Thermo Scientific, (2013).
5. Dunn, S.R., Qi, Z., Bottinger, E.P., Breyer, M.D. & Sharma, K. Utility of endogenous creatinine clearance as a measure of renal function in mice. Kidney Int. 65 (5), 1959-1967 (2004).
6. Eisner, C., Faulhaber-Walter, R., et al. Major contribution of tubular secretion to creatinine clearance in mice. Kidney Int. 77 (6), 519-526 (2010).
7. Faulhaber-Walter, R., Chen, L., et al. Lack of A1 adenosine receptors augments diabetic hyperfiltration and glomerular injury. J. Am. Soc. Nephrol. 19 (4), 722-730 (2008).
8. Fingl, E. Tubular excretion of creatinine in the rat. Am. J. Physiol. 169 (2), 357-362 (1952).
9. Keppler, A., Gretz, N., et al. Plasma creatinine determination in mice and rats: an enzymatic method compares favorably with a high-performance liquid chromatography assay. Kidney Int. 71 (1), 74-78 (2007).
10. Levey, A.S., Perrone, R.D., & Madias, N.E. Serum creatinine and renal function. Annu. Rev. Med. 39, 465-490 (1988).
11. Lorenz, J.N. & Gruenstein, E. A simple, nonradioactive method for evaluating single-nephron filtration rate using FITC-inulin. Am. J. Physiol. 276 (1 Pt. 2), F172-F177 (1999).
12. Meyer, M.H., Meyer, R.A., Jr., Gray, R.W., & Irwin, R.L. Picric acid methods greatly overestimate serum creatinine in mice: more accurate results with high-performance liquid chromatography. Anal. Biochem. 144 (1), 285-290 (1985).
13. Qi, Z. & Breyer, M.D. Measurement of glomerular filtration rate in conscious mice. Methods Mol. Biol. 466, 61-72 (2009).
14. Qi, Z., Whitt, I., et al. Serial determination of glomerular filtration rate in conscious mice using FITC-inulin clearance. Am. J. Physiol. Renal Physiol. 286 (3), F590-F596 (2004).
15. Schock-Kusch, D., Sadick, M., et al. Transcutaneous measurement of glomerular filtration rate using FITC-sinistrin in rats. Nephrol. Dial Transplant. 24 (10), 2997-3001 (2009).
16. Schock-Kusch, D., Xie, Q., et al. Transcutaneous assessment of renal function in conscious rats with a device for measuring FITC-sinistrin disappearance curves. Kidney Int. 79 (11), 1254-1258 (2011).
17. Schreiber, A., Shulhevich, Y., et al. Transcutaneous measurement of renal function in conscious mice. Am. J. Physiol. Renal Physiol. 303 (5), F783-F788 (2012).
18. Shemesh, O., Golbetz, H., Kriss, J.P., & Myers, B.D. Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int. 28 (5), 830-838 (1985).
19. Sturgeon, C., Sam, A.D., & Law, W.R. Rapid determination of glomerular filtration rate by single-bolus inulin: a comparison of estimation analyses. J. Appl. Physiol. 84 (6), 2154-2162 (1998).
20. Vallon, V., Blantz, R.C., & Thomson, S. Glomerular hyperfiltration and the salt paradox in early [corrected] type 1 diabetes mellitus: a tubulo-centric view. J. Am. Soc. Nephrol. 14 (2), 530-537 (2003).
21. Vallon, V., Eraly, S.A., et al. A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Am. J. Physiol. Renal Physiol. 302 (10), F1293-F1299 (2012).
22. Vallon, V., Schroth, J., et al. Adenosine A(1) receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus. Nephron. Physiol. 111 (3), 30-38 (2009).
23. Yardeni, T., Eckhaus, M., Morris, H.D., Huizing, M., & Hoogstraten-Miller, S. Retro-orbital injections in mice. Lab Anim. (NY). 40 (5), 155-160 (2011)