Whole-body nanoparticle aerosol inhalation exposures

Journal of Visualized Experiments

Volumn , Issue 75, 2013, Pages

  Yi, Jinghai ^a,b   Chen, Bean T ^c   Schwegler Berry, Diane ^c   Frazer, Dave ^c   Castranova, Vince ^c   McBride, Carroll ^a   Knuckles, Travis L ^a,b   Stapleton, Phoebe A ^a,b   Minarchick, Valerie C ^a,b   Nurkiewicz, Timothy R ^a,b  

^a WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c National Institute for Occupational Safety and Health   (Malaysia)

Author keywords

Aerosols; Anatomy; Animal model; Biomedical Engineering; Chemistry; Dry powder; Engineered nanomaterials; Inhalation exposure; Issue 75; Medicine; Nanoparticle; Pharmacology; Physiology; Titanium dioxide; Toxicology

Indexed keywords

NANOPARTICLE; TITANIUM; TITANIUM DIOXIDE;

AEROSOL; ANIMAL; ARTICLE; CHEMISTRY; EQUIPMENT; EXPOSURE; METHODOLOGY; MOUSE; RAT; TOXICITY TESTING;

AEROSOLS; ANIMALS; INHALATION EXPOSURE; MICE; NANOPARTICLES; RATS; TITANIUM; TOXICITY TESTS;

EID: 84877733302     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/50263     Document Type: Article

References (10)

1. Bide, R.W., Armour, S.J., & Yee, E. Allometric respiration/body mass data for animals to be used for estimates of inhalation toxicity to young adult humans. J. Appl. Toxicol. 20 (4), 273-90 (2000).
2. Guyton, A.C. Analysis of respiratory patterns in laboratory animals. Am. J. Physiol. 150, 70-7 (1947).
3. Knuckles, T.L., Yi, J., Frazer, D.G., Leonard, H.D., Chen, B.T., Castranova, V., & Nurkiewicz, T.R. Nanoparticle inhalation alters systemic arteriolar vasoreactivity through sympathetic and cyclooxygenase-mediated pathways. Nanotoxicology. July, 1-12 (2011).
4. Pauluhn, J. & Mohr, U., Repeated 4-week inhalation exposure of rats: effect of low-, intermediate, and high-humidity chamber atmosphere. Exp. Toxic Pathol., 178-187 (1999).
5. Schmoll, L.H., Elzey, S., Grassian, V.H., & O'Shaughnessy P.T. Nanoparticle aerosol generation methods from bulk powders for inhalation exposure studies. Nanotoxicology. 3, 265-275 (2009).
6. To, D., Yin, X., Sundaresan, S., & Dave, R.N. Deagglomeration of nano-particle aggregates via rapid expansion of high pressure suspensions. AIChE J. 55 (11), 2756-3032 (2009).
7. U.S. Environmental Protection Agency (US EPA). Health effects test guidelines: OPPTS., 870.1300. Acute inhalation toxicity. EPA 712-C-98-193 (1998).
8. Wong, B.A. Automated feedback control of an inhalation exposure system with discrete sampling intervals: testing, performance, and modeling. Inhal. Toxicol. 15, 729-43 (2003).
9. Wong B.A. Inhalation Exposure Systems: Design, Methods and Operation. Toxicologic Pathology. 35, 3-14 (2007).
10. Yi, J. & Nurkiewicz, T.R. Nanoparticle Aerosol Generator, U.S. Patent Application No. 13/317, 472 (2011)