HCV treatment - No more room for interferonologists?

New England Journal of Medicine

Volumn 368, Issue 20, 2013, Pages 1931-1932

  Drenth, Joost P H ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BOCEPREVIR; PEGINTERFERON; PEGINTERFERON ALPHA2A; PLACEBO; RIBAVIRIN; SOFOSBUVIR; TELAPREVIR;

ANEMIA; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; DOSAGE SCHEDULE COMPARISON; DRUG EFFICACY; DRUG SAFETY; DRUG TARGETING; EDITORIAL; GENOTYPE; HEMOLYTIC ANEMIA; HEPATITIS C; HUMAN; INCIDENCE; LEUKOPENIA; MICROBIOLOGICAL PARAMETERS; OPEN STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SUSTAINED VIROLOGIC RESPONSE; TREATMENT CONTRAINDICATION; TREATMENT DURATION; TREATMENT FAILURE; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; VIRUS REPLICATION;

EID: 84877731714     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMe1303818     Document Type: Editorial

References (7)

1. Zeuzem S, Andreone P, Pol S, et al. Telaprevir for retreatment of HCV infection. N Engl J Med 2011;364:2417-28.
2. Bacon BR, Gordon SC, Lawitz E, et al. Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med 2011;364:1207-17.
3. Jacobson IM, Gordon SC, Kowdley KV, et al. Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med 2013;368:1867-77.
4. Lawitz E, Mangia A, Wyles D, et al. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med 2013;368:1878-87.
5. Sofia MJ, Bao D, Chang W, et al. Discovery of a β-d-2′-deoxy- 2′-α-fluoro-2′-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem 2010;53:7202-18.
6. Gane EJ, Stedman CA, Hyland RH, et al. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C. N Engl J Med 2013;368:34-44.
7. Chen J, Florian J, Carter W, et al. Earlier sustained virologic response endpoints for regulatory approval and dose selection of hepatitis C therapies. Gastroenterology 2013 March 4 (Epub ahead of print).