Anticancer mechanisms of temporin-1CEa, an amphipathic α-helical antimicrobial peptide, in Bcap-37 human breast cancer cells

Life Sciences

Volumn 92, Issue 20-21, 2013, Pages 1004-1014

  Wang, Che ^a   Zhou, Yang ^a   Li, Song ^b   Li, Huibing ^a   Tian, Lili ^a   Wang, He ^a   Shang, Dejing ^a  

^a LIAONING NORMAL UNIVERSITY   (China)

^b DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Antimicrobial peptide; Bcap 37; Cytotoxicity; Membrane disruption; Mitochondria; Temporin 1CEa

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; POLYPEPTIDE ANTIBIOTIC AGENT; REACTIVE OXYGEN METABOLITE; TEMPORIN 1CEA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CALCIUM CELL LEVEL; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL SURFACE; CONTROLLED STUDY; ELECTRON MICROSCOPE; FLOW CYTOMETRY; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL;

ANTIMICROBIAL CATIONIC PEPTIDES; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CALCIUM; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; FEMALE; FLOW CYTOMETRY; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON; PEPTIDES; REACTIVE OXYGEN SPECIES;

MAMMALIA;

EID: 84877730352     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2013.03.016     Document Type: Article

References (38)

1. D. Ausbacher, G. Svineng, T. Hansen, and M.B. Strøm Anticancer mechanisms of action of two small amphipathic β(2,2)-amino acid derivatives derived from antimicrobial peptides Biochim Biophys Acta 1818 2012 2917 2925
2. B. Bechinger Structure and functions of channel-forming peptides: magainins, cecropins, melittin and alamethicin J Membr Biol 156 1997 197 211
3. H.G. Boman Antibacterial peptides: basic facts and emerging concepts J Intern Med 254 2003 197 215
4. J.M. Conlon, R. Al-Kharrge, E. Ahmed, H. Raza, S. Galadari, and E. Condamine Effect of aminoisobutyric acid (Aib) substitutions on the antimicrobial and cytolytic activities of the frog skin peptide, temporin-1DRa Peptides 28 2007 2075 2080
5. L.T. Eliassen, B.E. Haug, G. Berge, and O. Rekdal Enhanced antitumor activity of 15-residue bovine Lactoferricin derivatives containing bulky aromatic amino acids and lipophilic N-terminal modifications J Pept Sci 9 2003 510 517
6. L.T. Eliassen, G. Berge, A. Leknessund, M. Wikman, I. Lindin, and C. Løkke The antimicrobial peptide, Lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo Int J Cancer 119 2006 493 500
7. R. Franco, C.D. Bortner, and J.A. Cidlowski Potential roles of electrogenic ion transport and plasma membrane depolarization in apoptosis J Membr Biol 209 2006 43 58
8. S.J. Furlong, J.S. Mader, and D.W. Hoskin Lactoferricin-induced apoptosis in estrogen-nonresponsive MDA-MB-435 breast cancer cells is enhanced by C6 ceramide or tamoxifen Oncol Rep 15 2006 1385 1390
9. L. Gatti, and F. Zunino Overview of tumor cell chemoresistance mechanisms Methods Mol Med 111 2005 127 148
10. E.J. Helmerhorst, P. Breeuwer, W. van't Hof, E. Walgreen-Weterings, L.C. Oomen, and E.C. Veerman The cellular target of histatin 5 on Candida albicans is the energized mitochondrion J Biol Chem 274 1999 7286 7291
11. D.W. Hoskin, and A. Ramamoorthy Studies on anticancer activities of antimicrobial peptides Biochim Biophys Acta 1778 2008 357 375
12. G. Kroemer, B. Dallaporta, and M. Resche-Rigon The mitochondrial death/life regulator in apoptosis and necrosis Annu Rev Physiol 60 1998 619 642
13. M.M. Kulkarni, W.R. McMaster, W. Kamysz, and B.S. McGwire Antimicrobial peptide-induced apoptotic death of leishmania results from calcium-dependent, caspase-independent mitochondrial toxicity J Biol Chem 284 2009 15496 15504
14. C. Leuschner, and W. Hansel Membrane disrupting lytic peptides for cancer treatments Curr Pharm Des 10 2004 2299 2310
15. Y. Lu, J. Li, H. Yu, X. Xu, J. Liang, and Y. Tian Two families of antimicrobial peptides with multiple functions from skin of rufous-spotted torrent frog, Amolops loloensis Peptides 27 2006 3085 3091
16. J.D. Ly, D.R. Grubb, and A. Lawen The mitochondrial membrane potential (Δφ(m)) in apoptosis; an update Apoptosis 8 2003 115 128
17. J.S. Mader, and D.W. Hoskin Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment Expert Opin Investig Drugs 15 2006 933 946
18. J.S. Mader, J. Salman, D.M. Conrad, and D.W. Hoskin Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines Mol Cancer Ther 4 2005 612 624
19. J.S. Mader, A. Richardson, J. Salsman, D. Top, R. de Antueno, and R. Duncan Bovine lactoferricin causes apoptosis in Jurkat T-leukemia cells by sequential permeabilization of the cell membrane and targeting of mitochondria Exp Cell Res 313 2007 2634 2650
20. M.L. Mangoni Temporins, anti-infective peptides with expanding properties Cell Mol Life Sci 63 2006 1060 1069
21. M.L. Mangoni, and Y. Shai Temporins and their synergism against gram-negative bacteria and in lipopolysaccharide detoxification Biochim Biophys Acta 1788 2009 1610 1619
22. J.B. McPhee, and R.E. Hancock Function and therapeutic potential of host defense peptides J Pept Sci 11 2005 677 687
23. K. Ono, S.O. Kim, and J. Han Susceptibility of lysosomes to rupture is a determinant for plasma membrane disruption in tumor necrosis factor alpha-induced cell death Mol Cell Biol 23 2003 665 676
24. S. Orrenius, B. Zhivotovsky, and P. Nicotera Regulation of cell death: the calcium-apoptosis link Nat Rev Mol Cell Biol 4 2003 552 565
25. N. Papo, and Y. Shai Host defense peptides as new weapons in cancer treatment Cell Mol Life Sci 62 2005 784 790
26. E.J. Paredes-Gamero, M.N. Martins, F.A. Cappabianco, J.S. Ide, and A. Miranda Characterization of dual effects induced by antimicrobial peptides: regulated cell death or membrane disruption Biochim Biophys Acta 1820 2012 1062 1072
27. A. Risso, M. Zanetti, and R. Gennaro Cytotoxicity and apoptosis mediated by two peptides of innate immunity Cell Immunol 189 1998 107 115
28. L.C. Salay, J. Procopio, E. Oliveira, C.R. Nakaie, and S. Schreier Ion channel-like activity of the antimicrobial peptide tritrpticin in planar lipid bilayers FEBS Lett 565 2004 171 175
29. C. Segura, F. Guzman, L.M. Salazar, M.E. Patarroyo, S. Orduz, and V. Lemeshko BTM-P1 polycationic peptide biological activity and 3D-dimensional structure Biochem Biophys Res Commun 353 2007 908 914
30. D.J. Shang, F.H. Yu, J.F. Li, J.J. Zheng, L.F. Zhang, and Y. Li Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis Zool Sci 26 2009 220 226
31. M. Simmaco, D. De Biase, C. Severini, M. Aita, G.F. Erspamer, and D. Barra Purification and characterization of bioactive peptides from skin extracts of Rana esculenta Biochim Biophys Acta 1033 1990 318 323
32. M. Simmaco, G. Mignogna, S. Canofeni, R. Miele, M.L. Mangoni, and D. Barra Temporins, antimicrobial peptides from the European red frog Rana temporaria Eur J Biochem 242 1996 788 792
33. C. Vande Velde, J. Cizeau, D. Dubik, J. Alimonti, T. Brown, and S. Israels BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore Mol Cell Biol 20 2000 5454 5468
34. R. Wang, X. Wang, B. Li, F. Lin, K. Dong, and P. Gao Tumor-specific adenovirus-mediated PUMA gene transfer using the survivin promoter enhances radiosensitivity of breast cancer cells in vitro and in vivo Breast Cancer Res Treat 117 2009 45 54
35. C. Wang, H.B. Li, S. Li, L.L. Tian, and D.J. Shang Antitumor effects and cell selectivity of temporin-1CEa, an antimicrobial peptide from the skin secretions of the Chinese brown frog (Rana chensinensis) Biochimie 94 2012 434 441
36. C. Wang, L.L. Tian, S. Li, H.B. Li, Y. Zhou, and H. Wang Rapid cytotoxicity of antimicrobial peptide tempoprin-1CEa in breast cancer cells through membrane destruction and intracellular calcium mechanism PLoS One 8 2013 e60462
37. Y.C. Yoo, S. Watanabe, R. Watanabe, K. Hata, K. Shimazaki, and I. Azuma Bovine lactoferrin and lactoferricin, a peptide derived from bovine lactoferrin, inhibit tumor metastasis in mice Jpn J Cancer Res 88 1997 184 190
38. M. Zasloff Antimicrobial peptides of multicellular organisms Nature 415 2002 389 395