16 and 24 Gy low-voltage X-ray irradiation with ranibizumab therapy for neovascular age-related macular degeneration: 12-month outcomes

American Journal of Ophthalmology

Volumn 155, Issue 6, 2013, Pages

  Morales Canton, Virgilio ^a   Quiroz Mercado, Hugo ^a,b   Velez Montoya, Raul ^a,b   Zavala Ayala, Alicia ^a   Moshfeghi, Andrew A ^c   Shusterman, E Mark ^d   Kaiser, Peter K ^e   Sanislo, Steven R ^f   Gertner, Michael ^d   Moshfeghi, Darius M ^f  

^a IAP ^*  (Mexico)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d Oraya Therapeutics Inc   (United States)

^e LERNER RESEARCH INSTITUTE   (United States)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RANIBIZUMAB;

ALLERGIC CONJUNCTIVITIS; ARTICLE; ASTHENOPIA; BLEPHARITIS; BLURRED VISION; CATARACT; CILIARY DISK; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONJUNCTIVAL HEMORRHAGE; CONJUNCTIVITIS; CONTROLLED STUDY; CORNEA INFILTRATE; EYE IRRITATION; EYE PAIN; FOLLOW UP; HERPES ZOSTER; HORDEOLUM; HUMAN; INTRAOCULAR PRESSURE; KERATITIS; KERATOPATHY; LACRIMATION; LEUKOMALACIA; LOADING DRUG DOSE; OCULAR HYPEREMIA; OCULAR PRURITUS; OPTIC NERVE DISEASE; OPTICAL COHERENCE TOMOGRAPHY; PHASE 1 CLINICAL TRIAL; PHOTOPSIA; PRIORITY JOURNAL; RADIATION DOSE; RETINA MACULA AGE RELATED DEGENERATION; RETINA VEIN OCCLUSION; RETINAL THICKNESS; RETINOPATHY; RISK ASSESSMENT; SIDE EFFECT; TREATMENT OUTCOME; TRICHIASIS; VIRAL CONJUNCTIVITIS; VISION; VISUAL ACUITY; VITREOUS FLOATERS; X IRRADIATION;

EID: 84877727185     PISSN: 00029394     EISSN: 18791891     Source Type: Journal    
DOI: 10.1016/j.ajo.2013.01.015     Document Type: Article

References (29)

1. D.M. Moshfeghi, P.K. Kaiser, and M. Gertner Stereotactic low-voltage x-ray irradiation for age-related macular degeneration Br J Ophthalmol 95 2 2011 185 188
2. J. Hanlon, M. Firpo, E. Chell, D.M. Moshfeghi, and W.E. Bolch Stereotactic radiosurgery for AMD: a Monte Carlo-based assessment of patient-specific tissue doses Invest Ophthalmol Vis Sci 52 5 2011 2334 2342
3. P.J. Taddei, E. Chell, S. Hansen, M. Gertner, and W.D. Newhauser Assessment of targeting accuracy of a low-energy stereotactic radiosurgery treatment for age-related macular degeneration Phys Med Biol 55 23 2010 7037 7054
4. C. Lee, E. Chell, and M. Gertner Dosimetry characterization of a multibeam radiotherapy treatment for age-related macular degeneration Med Phys 35 11 2008 5151 5160
5. J. Hanlon, C. Lee, and E. Chell Kilovoltage stereotactic radiosurgery for age-related macular degeneration: assessment of optic nerve dose and patient effective dose Med Phys 36 8 2009 3671 3681
6. M. Gertner, E. Chell, K.H. Pan, S. Hansen, P.K. Kaiser, and D.M. Moshfeghi Stereotactic targeting and dose verification for age-related macular degeneration Med Phys 37 2 2010 600 606
7. M.R. Barakat, M. Shusterman, D. Moshfeghi, R. Danis, M. Gertner, and R.P. Singh Pilot study of the delivery of microcollimated pars plana external beam radiation in porcine eyes Arch Ophthalmol 129 5 2011 628 632
8. R.P. Singh, E.M. Shusterman, D. Moshfeghi, R. Danis, and M. Gertner Pilot study of the delivery of microcollimated pars plana external beam radiation in porcine eyes: 270-day analysis J Ophthalmol 2012 2012 615214
9. A.A. Moshfeghi, V.M. Canton, and H. Quiroz-Mercado 16-Gy low-voltage x-ray irradiation followed by as-needed ranibizumab therapy for AMD: 6-month outcomes of a "radiation-first" strategy Ophthalmic Surg Lasers Imaging 42 6 2011 460 467
10. V.M. Canton, H. Quiroz-Mercado, and R. Velez-Montoya 16-Gy low-voltage x-ray irradiation with ranibizumab therapy for AMD: 6-month safety and functional outcomes Ophthalmic Surg Lasers Imaging 42 6 2011 468 473
11. A.A. Moshfeghi, V. Morales-Canton, and H. Quiroz-Mercado 16 Gy low-voltage x-ray irradiation followed by as needed ranibizumab therapy for age-related macular degeneration: 12 month outcomes of a 'radiation-first' strategy Br J Ophthalmol 96 10 2012 1320 1324
12. D.M. Brown, and C.D. Regillo Anti-VEGF agents in the treatment of neovascular age-related macular degeneration: applying clinical trial results to the treatment of everyday patients Am J Ophthalmol 144 4 2007 627 637
13. C.D. Regillo, D.M. Brown, and P. Abraham Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1 Am J Ophthalmol 145 2 2008 239 248.e235
14. P.J. Rosenfeld, D.M. Brown, and J.S. Heier Ranibizumab for neovascular age-related macular degeneration N Engl J Med 355 14 2006 1419 1431
15. U. Chakravarthy, R.F. Houston, and D.B. Archer Treatment of age-related subfoveal neovascular membranes by teletherapy: a pilot study Br J Ophthalmol 77 5 1993 265 273
16. U. Chakravarthy, and G. MacKenzie External beam radiotherapy in exudative age-related macular degeneration: a pooled analysis of phase I data Br J Radiol 73 867 2000 305 313
17. J.R. Evans, V. Sivagnanavel, and V. Chong Radiotherapy for neovascular age-related macular degeneration Cochrane Database Syst Rev 5 2010 CD004004
18. P.T. Finger, A. Berson, T. Ng, and A. Szechter Ophthalmic plaque radiotherapy for age-related macular degeneration associated with subretinal neovascularization Am J Ophthalmol 127 2 1999 170 177
19. P.T. Finger, A. Berson, D. Sherr, R. Riley, R.A. Balkin, and J.L. Bosworth Radiation therapy for subretinal neovascularization Ophthalmology 103 6 1996 878 889
20. P.T. Finger, Y.P. Gelman, A.M. Berson, and A. Szechter Palladium-103 plaque radiation therapy for macular degeneration: results of a 7 year study Br J Ophthalmol 87 12 2003 1497 1503
21. C.J. Flaxel, E.J. Friedrichsen, and J.O. Smith Proton beam irradiation of subfoveal choroidal neovascularisation in age-related macular degeneration Eye 14 Pt 2 2000 155 164
22. A. Jaakkola, J. Heikkonen, A. Tarkkanen, and I. Immonen Visual function after strontium-90 plaque irradiation in patients with age-related subfoveal choroidal neovascularization Acta Ophthalmol Scand 77 1 1999 57 61
23. A. Jaakkola, J. Heikkonen, P. Tommila, L. Laatikainen, and I. Immonen Strontium plaque irradiation of subfoveal neovascular membranes in age-related macular degeneration Graefes Arch Clin Exp Ophthalmol 236 1 1998 24 30
24. A. Jaakkola, J. Heikkonen, P. Tommila, L. Laatikainen, and I. Immonen Strontium plaque brachytherapy for exudative age-related macular degeneration: three-year results of a randomized study Ophthalmology 112 4 2005 567 573
25. A. Jaakkola, P. Tommila, L. Laatikainen, and I. Immonen Grading choroidal neovascular membrane regression after strontium plaque radiotherapy; masked subjective evaluation vs planimetry Eur J Ophthalmol 11 3 2001 269 276
26. V. Sivagnanavel, J.R. Evans, Z. Ockrim, and V. Chong Radiotherapy for neovascular age-related macular degeneration Cochrane Database Syst Rev 4 2004 CD004004
27. H.J. Zambarakji, A.M. Lane, and E. Ezra Proton beam irradiation for neovascular age-related macular degeneration Ophthalmology 113 11 2006 2012 2019
28. M.P. Avila, M.E. Farah, and A. Santos Twelve-month safety and visual acuity results from a feasibility study of intraocular, epiretinal radiation therapy for the treatment of subfoveal CNV secondary to AMD Retina 29 2 2009 157 169
29. M.P. Avila, M.E. Farah, A. Santos, J.P. Duprat, B.W. Woodward, and J. Nau Twelve-month short-term safety and visual-acuity results from a multicentre prospective study of epiretinal strontium-90 brachytherapy with bevacizumab for the treatment of subfoveal choroidal neovascularisation secondary to age-related macular degeneration Br J Ophthalmol 93 3 2009 305 309