16-Gy low-voltage x-ray irradiation followed by as-needed ranibizumab therapy for AMD: 6-month outcomes of a "radiation-first" strategy

Ophthalmic Surgery Lasers and Imaging

Volumn 42, Issue 6, 2011, Pages 460-467

  Moshfeghi, Andrew A ^a   Canton, Virgilio Morales ^b   Quiroz Mercado, Hugo ^b,c   Velez Montoya, Raul ^b,c   Lopez Miranda, Miriam J ^b   Shusterman, Eugene M ^d   Kaiser, Peter K ^e   Sanislo, Steven R ^f   Gertner, Michael ^d   Moshfeghi, Darius M ^f  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b IAP ^*  (Mexico)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d Oraya Therapeutics Inc   (United States)

^e LERNER RESEARCH INSTITUTE   (United States)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RANIBIZUMAB;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DRUG SAFETY; FEMALE; FOLLOW UP; HUMAN; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RADIATION DOSE; RETINA MACULA AGE RELATED DEGENERATION; TREATMENT OUTCOME; VISUAL ACUITY; X IRRADIATION;

AGED; AGED, 80 AND OVER; ANGIOGENESIS INHIBITORS; ANTIBODIES, MONOCLONAL; ANTIBODIES, MONOCLONAL, HUMANIZED; COMBINED MODALITY THERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MACULAR DEGENERATION; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SALVAGE THERAPY; VISUAL ACUITY; X-RAY THERAPY;

EID: 83055174622     PISSN: 15428877     EISSN: None     Source Type: Journal    
DOI: 10.3928/15428877-20110804-03     Document Type: Article

References (38)

1. Stevenson MR, Hart PM, Chakravarthy U, et al. Visual functioning and quality of life in the SubFoveal Radiotherapy Study (SFRADS): SFRADS report 2. Br J Ophthalmol. 2005;89:1045-1051. (Pubitemid 41081422)
2. Barak A, Hauser D, Yipp P, et al. A phase I trial of stereotactic external beam radiation for subfoveal choroidal neovascular membranes in age-related macular degeneration. Br J Radiol. 2005;78:827-831. (Pubitemid 41246152)
3. Sivagnanavel V, Evans JR, Ockrim Z, Chong V. Radiotherapy for neovascular age-related macular degeneration. Cochrane Database Syst Rev. 2004;(4):CD004004.
4. Prettenhofer U, Haas A, Mayer R, Stranzl H, Oechs A, Hackl A. Long-term results after external radiotherapy in age-related macular degeneration: a prospective study. Strahlenther Onkol. 2004;180:91-95. (Pubitemid 38165880)
5. Marcus DM, Sheils WC, Young JO, et al. Radiotherapy for recurrent choroidal neovascularisation complicating age related macular degeneration. Br J Ophthalmol. 2004;88:114-119. (Pubitemid 38091376)
6. Marcus DM, Peskin E, Maguire M, et al. The Age-Related Macular Degeneration Radiotherapy Trial (AMDRT): one year results from a pilot study. Am J Ophthalmol. 2004;138:818-828. (Pubitemid 39452930)
7. Churei H, Ohkubo K, Nakajo M, et al. External-beam radiation therapy for age-related macular degeneration: two years' follow-up results at a total dose of 20 Gy in 10 fractions. Radiat Med. 2004;22:398-404. (Pubitemid 40144017)
8. Aisenbrey S, Lafaut BA, Reynders S, et al. Clinicopathological correlation of choroidal neovascularization after external beam radiotherapy in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 2003;241:269-276. (Pubitemid 36748556)
9. The results of randomized controlled trial of low-dose radiation for wet-type age-related macular degeneration on a 1 year term basis [article in Japanese]. Nippon Ganka Gakkai Zasshi. 2003;107:326-330.
10. Valmaggia C, Ries G, Ballinari P. Radiotherapy for subfoveal choroidal neovascularization in age-related macular degeneration: a randomized clinical trial. Am J Ophthalmol. 2002;133:521-529. (Pubitemid 34258061)
11. Hart PM, Chakravarthy U, Mackenzie G, et al. Visual outcomes in the subfoveal radiotherapy study: a randomized controlled trial of teletherapy for age-related macular degeneration. Arch Ophthalmol. 2002;120:1029-1038. (Pubitemid 34856070)
12. Marcus DM, Sheils W, Johnson MH, et al. External beam irradiation of subfoveal choroidal neovascularization complicating age-related macular degeneration: one-year results of a prospective, double-masked, randomized clinical trial. Arch Ophthalmol. 2001;119:171-180. (Pubitemid 32147923)
13. Chakravarthy U, MacKenzie G. External beam radiotherapy in exudative age-related macular degeneration: a pooled analysis of phase I data. Br J Radiol. 2000;73:305-313. (Pubitemid 30192804)
14. Staar S, Krott R, Mueller RP, Bartz-Schmidt KU, Heimann K. External beam radiotherapy for subretinal neovascularization in age-related macular degeneration: is this treatment efficient? Int J Radiat Oncol Biol Phys. 1999;45:467-473. (Pubitemid 29408566)
15. Roos DE, Francis JW, Newnham WJ. A simple technique for treating age-related macular degeneration with external beam radiotherapy. Int J Radiat Oncol Biol Phys. 1999;43:1071-1074. (Pubitemid 29144797)
16. Donati G, Soubrane D, Quaranta M, Coscas G, Soubrane G. Radiotherapy for isolated occult subfoveal neovascularisation in age related macular degeneration: a pilot study. Br J Ophthalmol. 1999;83:646-651. (Pubitemid 29261650)
17. Char DH, Irvine AI, Posner MD, Quivey J, Phillips TL, Kroll S. Randomized trial of radiation for age-related macular degeneration. Am J Ophthalmol. 1999;127:574-578. (Pubitemid 29215769)
18. Berson AM, Finger PT, Chakravarthy U. Radiation therapy for age-related macular degeneration. Semin Radiat Oncol. 1999;9:155-162. (Pubitemid 29187968)
19. A prospective, randomized, double-masked trial on radiation therapy for neovascular age-related macular degeneration (RAD study): radiation therapy for age-related macular degeneration. Ophthalmology. 1999;106:2239-2247.
20. Krott R, Staar S, Müller RP, Bartz-Schmidt KU, Esser P, Heimann K. External beam radiation in patients suffering from exudative age-related macular degeneration: a matched-pairs study and 1-year clinical follow-up. Graefes Arch Clin Exp Ophthalmol. 1998;236:916-921. (Pubitemid 28546506)
21. Finger PT, Chakravarthy U, Augsburger JJ. Radiotherapy and the treatment of age-related macular degeneration: external beam radiation therapy is effective in the treatment of age-related macular degeneration. Arch Ophthalmol. 1998;116:1507-1511.
22. Akmansu M, Dîrîcan B, Oztürk B, Egehan I, Subasi M, Or M. External radiotherapy in macular degeneration: our technique, dosimetric calculation, and preliminary results. Int J Radiat Oncol Biol Phys. 1998;40:923-927. (Pubitemid 28150811)
23. Sasai K, Murata R, Mandai M, et al. Radiation therapy for ocular choroidal neovascularization (phase I/II study): preliminary report. Int J Radiat Oncol Biol Phys. 1997;39:173-178. (Pubitemid 27396294)
24. Finger PT, Berson A, Sherr D, Riley R, Balkin RA, Bosworth JL. Radiation therapy for subretinal neovascularization. Ophthalmology. 1996;103:878-889. (Pubitemid 26190720)
25. Berson AM, Finger PT, Sherr DL, Emery R, Alfieri AA, Bosworth JL. Radiotherapy for age-related macular degeneration: preliminary results of a potentially new treatment. Int J Radiat Oncol Biol Phys. 1996;36:861-865. (Pubitemid 27008601)
26. Bergink Bergink GJ, Deutman AF, van den Broek JE, van Daal WA, van der Maazen RM. Radiation therapy for age-related subfoveal choroidal neovascular membranes: a pilot study. Doc Ophthalmol. 1995;1:67-74.
27. Bergink GJ, Deutman AF, van den Broek JF, van Daal WA, van der Maazen RW. Radiation therapy for subfoveal choroidal neovascular membranes in age-related macular degeneration: a pilot study. Graefes Arch Clin Exp Ophthalmol. 1994;232:591-598. (Pubitemid 24280286)
28. Finger PT, Gelman YP, Berson AM, Szechter A. Palladium-103 plaque radiation therapy for macular degeneration: results of a 7 year study. Br J Ophthalmol. 2003;87:1497-1503. (Pubitemid 38010556)
29. Saric B, Sikic J, Katusic D, Vukojevic N. Brachytherapy: optional treatment for choroidal neovascularization secondary to age-related macular degeneration. Coll Antropol. 2001;25(suppl):89-96. (Pubitemid 33743275)
30. Jaakkola A, Tommila P, Laatikainen L, Immonen I. Grading choroidal neovascular membrane regression after strontium plaque radiotherapy: masked subjective evaluation vs planimetry. Eur J Ophthalmol. 2001;11:269-276. (Pubitemid 33042279)
31. Furdová A, Strmen P. Brachytherapy in the treatment of age-related macular degeneration [article in Slovak]. Bratisl Lek Listy. 2000;101:234-236.
32. Jaakkola A, Heikkonen J, Tarkkanen A, Immonen I. Visual function after strontium-90 plaque irradiation in patients with age-related subfoveal choroidal neovascularization. Acta Ophthalmol Scand. 1999;77:57-61. (Pubitemid 29057489)
33. Finger PT, Berson A, Ng T, Szechter A. Ophthalmic plaque radiotherapy for age-related macular degeneration associated with subretinal neovascularization. Am J Ophthalmol. 1999;127:170-177. (Pubitemid 29072557)
34. Jaakkola A, Heikkonen J, Tommila P, Laatikainen L, Immonen I. Strontium plaque irradiation of subfoveal neovascular membranes in age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 1998;236:24-30. (Pubitemid 28080567)
35. Emery RS, Szechter A. Seed localization in eye plaque brachytherapy. Med Phys. 1998;25:1491-1492. (Pubitemid 28376363)
36. Avila MP, Farah ME, Santos A, et al. Twelve-month safety and visual acuity results from a feasibility study of intraocular, epimacular radiation therapy for the treatment of subfoveal CNV secondary to AMD. Retina. 2009;29:157-169.
37. Avila MP, Farah ME, Santos A, Duprat JP, Woodward BW, Nau J. Twelve-month short-term safety and visual-acuity results from a multicentre prospective study of epimacular strontium-90 brachytherapy with bevacizumab for the treatment of subfoveal choroidal neovascularisation secondary to age-related macular degeneration. Br J Ophthalmol. 2009;93:305-309.
38. Brenner DJ, Leu CS, Beatty JF, Shefer RE. Clinical relative biological effectiveness of low-energy x-rays emitted by miniature x-ray devices. Phys Med Biol. 1999;44:323-333.