A role for 16S rRNA dimethyltransferase (ksgA) in intrinsic clarithromycin resistance in Mycobacterium tuberculosis

International Journal of Antimicrobial Agents

Volumn 41, Issue 6, 2013, Pages 548-551

  Phunpruch, Saranya ^a   Warit, Saradee ^b   Suksamran, Rungaroon ^a   Billamas, Pamaree ^b   Jaitrong, Sarinya ^b   Palittapongarnpim, Prasit ^b,c   Prammananan, Therdsak ^b  

^a KING MONGKUT'S INSTITUTE OF TECHNOLOGY LADKRABANG   (Thailand)

^b NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY   (Thailand)

^c Mahidol University ^*  (Thailand)

Author keywords

Macrolide; Methyltransferase; Resistance

Indexed keywords

CLARITHROMYCIN; RNA 16S;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATION; BIOGENESIS; CONTROLLED STUDY; DENATURATION; DISK DIFFUSION; DRUG SENSITIVITY; GEL ELECTROPHORESIS; GENE AMPLIFICATION; GENE INACTIVATION; KSGA GENE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DYNAMICS; MUTAGENESIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; RIBOSOME; TRANSPOSON;

ANTITUBERCULAR AGENTS; CLARITHROMYCIN; DNA TRANSPOSABLE ELEMENTS; DRUG RESISTANCE, BACTERIAL; GENE KNOCKOUT TECHNIQUES; GENETIC COMPLEMENTATION TEST; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS, INSERTIONAL; MYCOBACTERIUM TUBERCULOSIS;

EID: 84877712222     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2013.02.011     Document Type: Article

References (28)

1. World Health Organization Global tuberculosis control: report 2011 2011 WHO Geneva, Switzerland WHO/HTM/TB/2011.16
2. World Health Organization Treatment of tuberculosis: guidelines 4th ed. 2010 WHO Geneva, Switzerland WHO/HTM/TB/2009.420
3. F. Doucet-Populaire, K. Buriánková, J. Weiser, and J.L. Pernodet Natural and acquired macrolide resistance in mycobacteria Curr Drug Targets Infect Disord 2 2002 355 370
4. S. Andersson, and C.G. Kurland Elongating ribosomes in vivo are refractory to erythromycin Biochimie 69 1987 901 904
5. N. Andini, and K.A. Nash Intrinsic macrolide resistance of the Mycobacterium tuberculosis complex is inducible Antimicrob Agents Chemother 50 2006 2560 2562
6. C.T. Madsen, L. Jakobsen, K. Buriánková, F. Doucet-Populaire, J.L. Pernodet, and S. Douthwaite Methyltransferase Erm(37) slips on rRNA to confer atypical resistance in Mycobacterium tuberculosis J Biol Chem 280 2005 38942 38947
7. K. Buriánková, F. Doucet-Populaire, O. Dorson, A. Gondran, J.C. Ghnassia, and J. Weiser Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex Antimicrob Agents Chemother 48 2004 143 150
8. R.P. Morris, L. Nguyen, J. Gatfield, K. Visconti, K. Nguyen, and D. Schnappinger Ancestral antibiotic resistance in Mycobacterium tuberculosis Proc Natl Acad Sci U S A 102 2005 12200 12205
9. C.K. Stover, V.F. de la Cruz, T.R. Fuerst, J.E. Burlein, L.A. Benson, and L.T. Bennett New use of BCG for recombinant vaccines Nature 351 1991 456 460
10. P. O'Gaora, S. Barnini, C. Hayward, E. Filley, G. Rook, and D. Young Mycobacteria as immunogens: development of expression vectors for use in multiple mycobacterial species Med Prin Pract 6 1997 91 96
11. National Committee for Clinical Laboratory Standards Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes: approved standard. Document M24-A 2003 NCCLS Wayne, PA
12. L. Collins, and S.G. Franzblau Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium Antimicrob Agents Chemother 41 1997 1004 1009
13. P. Sander, T. Prammananan, A. Meier, K. Frischkorn, and E.C. Böttger The role of ribosomal RNAs in macrolide resistance Mol Microbiol 26 1997 469 480
14. B. Weisblum Erythromycin resistance by ribosome modification Antimicrob Agents Chemother 39 1995 577 585
15. A. Meier, P. Kirschner, B. Springer, V.A. Steingrube, B.A. Brown, and R.J. Wallace Jr. Identification of mutations in 23S rRNA gene of clarithromycin-resistant Mycobacterium intracellulare Antimicrob Agents Chemother 38 1994 381 384
16. S. Douthwaite Functional interactions within 23S rRNA involving the peptidyltransferase center J Bacteriol 174 1992 1333 1338
17. B.D. Kana, V. Mizrahi, and B.G. Gordhan Depletion of resuscitation- promoting factors has limited impact on the drug susceptibility of Mycobacterium tuberculosis J Antimicrob Chemother 65 2010 1583 1585
18. K. Ochi, J.Y. Kim, Y. Tanaka, G. Wang, K. Masuda, and H. Nanamiya Inactivation of KsgA, a 16S rRNA methyltransferase, causes vigorous emergence of mutants with high-level kasugamycin resistance Antimicrob Agents Chemother 53 2009 193 201
19. M.C. Roberts, J. Sutcliffe, P. Courvalin, L.B. Jensen, J. Rood, and H. Seppala Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants Antimicrob Agents Chemother 43 1999 2823 2830
20. H.C. O'Farrell, J.N. Scarsdale, and J.P. Rife Crystal structure of KsgA, a universally conserved rRNA adenine dimethyltransferase in Escherichia coli J Mol Biol 339 2004 337 353
21. K. Connolly, J.P. Rife, and G. Culver Mechanistic insight into the ribosome biogenesis functions of the ancient protein KsgA Mol Microbiol 70 2008 1062 1075
22. P.M. Desai, G.M. Culver, and J.P. Rife Site-directed mutants of 16S rRNA reveal important RNA domains for KsgA function and 30S subunit assembly Biochemistry 50 2011 854 863
23. H. Demirci, F. Murphy 4th, R. Belardinelli, A.C. Kelley, V. Ramakrishnan, and S.T. Gregory Modification of 16S ribosomal RNA by the KsgA methyltransferase restructures the 30S subunit to optimize ribosome function RNA 16 2010 2319 2324
24. D.L. Lafontaine, T. Preiss, and D. Tollervey Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis? Mol Cell Biol 18 1998 2360 2370
25. B.L. Seidel-Rogol, V. McCulloch, and G.S. Shadel Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop Nat Genet 33 2003 23 24
26. V. McCulloch, B.L. Seidel-Rogol, and G.S. Shadel A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine Mol Cell Biol 22 2002 1116 1125
27. M. Gaynor, and A.S. Mankin Macrolide antibiotics: binding site, mechanism of action, resistance Curr Top Med Chem 3 2003 949 961
28. R. Skinner, E. Cundliffe, and F.J. Schmidt Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics J Biol Chem 258 1983 12702 12706