Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα

Journal of Biological Chemistry

Volumn 288, Issue 19, 2013, Pages 13695-13703

  Seol, Yeonee ^a   Gentry, Amanda C ^b   Osheroff, Neil ^b   Neuman, Keir C ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL DOMAINS; CHIRAL DISCRIMINATION; HUMAN TOPOISOMERASE; RELAXATION MECHANISM; RELAXATION RATES; SINGLE MOLECULE MEASUREMENTS; TOPOISOMERASE II; TOPOISOMERASES;

BIOCHEMISTRY; BIOLOGY;

STEREOCHEMISTRY;

DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IIALPHA; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHIRALITY; CONTROLLED STUDY; DNA SUPERCOILING; ENZYME ACTIVITY; EUKARYOTE; MEASUREMENT; MOLECULAR BIOLOGY; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; PROTEIN PROCESSING; TENSION;

BIOPHYSICS; CHIRAL DISCRIMINATION; DNA REPLICATION; DNA TOPOISOMERASE; DNA TOPOLOGY; MAGNETIC TWEEZERS; SINGLE MOLECULE BIOPHYSICS;

ANTIGENS, NEOPLASM; DNA REPLICATION; DNA TOPOISOMERASES, TYPE II; DNA, SUPERHELICAL; DNA-BINDING PROTEINS; HUMANS; ISOMERISM; KINETICS; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION; SUBSTRATE SPECIFICITY;

EID: 84877702868     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.444745     Document Type: Article

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