A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: Multimers of phospholemman in ventricular muscle

Journal of Biological Chemistry

Volumn 288, Issue 19, 2013, Pages 13808-13820

  Wypijewski, Krzysztof J ^a   Howie, Jacqueline ^a   Reilly, Louise ^a   Tulloch, Lindsay B ^a   Aughton, Karen L ^b   McLatchie, Linda M ^b   Shattock, Michael J ^b   Calaghan, Sarah C ^c   Fuller, William ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGOMERS; PUMPS; SODIUM;

CARDIAC MUSCLES; MULTIMERS; PHOSPHOLAMBAN;

MUSCLE;

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CAVEOLIN; MEMBRANE PROTEIN; PHOSPHOLEMMAN; POLYMER; PROTEIN KINASE C; SERINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVATION; HEART MUSCLE CELL; HEART VENTRICLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; WILD TYPE;

EID: 84877700714     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.460956     Document Type: Article

References (52)

1. Sweadner, K. J., and Rael, E. (2000) The FXYD gene family of small ion transport regulators or channels. cDNA sequence, protein signature sequence, and expression. Genomics 68, 41-56
2. Geering, K. (2006) FXYD proteins. New regulators of Na-K-ATPase. Am. J. Physiol. Renal Physiol. 290, F241-F250
3. Crambert, G., Fuzesi, M., Garty, H., Karlish, S., and Geering, K. (2002) Phospholemman (FXYD1) associates with Na, K-ATPase and regulates its transport properties. Proc. Natl. Acad. Sci. U.S.A. 99, 11476-11481
4. Fuller, W., Eaton, P., Bell, J. R., and Shattock, M. J. (2004) Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. FASEB J. 18, 197-199
5. Fuller, W., Howie, J., McLatchie, L. M., Weber, R. J., Hastie, C. J., Burness, K., Pavlovic, D., and Shattock, M. J. (2009) FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes. Threonine 69 is a novel substrate for protein kinase C. Am. J. Physiol. Cell Physiol. 296, C1346-C1355
6. Silverman, B., Fuller, W., Eaton, P., Deng, J., Moorman, J. R., Cheung, J. Y., James, A. F., and Shattock, M. J. (2005) Serine 68 phosphorylation of phospholemman. Acute isoform-specific activation of cardiac Na/K ATPase. Cardiovasc. Res. 65, 93-103
7. Bossuyt, J., Despa, S., Han, F., Hou, Z., Robia, S. L., Lingrel, J. B., and Bers, D. M. (2009) Isoform specificity of the Na/K-ATPase association and regulation by phospholemman. J. Biol. Chem. 284, 26749-26757
8. Despa, S., Bossuyt, J., Han, F., Ginsburg, K. S., Jia, L. G., Kutchai, H., Tucker, A. L., and Bers, D. M. (2005) Phospholemman-phosphorylation mediates the β-adrenergic effects on Na/K pump function in cardiac myocytes. Circ. Res. 97, 252-259
9. + pump function in cardiac myocytes. Circ. Res. 99, 1376-1383
10. Fuller, W., Tulloch, L. B., Shattock, M. J., Calaghan, S. C., Howie, J., and Wypijewski, K. J. (2013) Regulation of the cardiac sodium pump. Cell Mol. Life Sci. 70, 1357-1380
11. Walaas, S. I., Czernik, A. J., Olstad, O. K., Sletten, K., and Walaas, O. (1994) Protein kinase Cand cyclic AMP-dependent protein kinase phosphorylate phospholemman, an insulin and adrenaline-regulated membrane phosphoprotein, at specific sites in the carboxy terminal domain. Biochem. J. 304, 635-640
12. Pavlović, D., Fuller, W., and Shattock, M. J. (2007) The intracellular region of FXYD1 is sufficient to regulate cardiac Na/K ATPase. FASEB J. 21, 1539-1546
13. Despa, S., Tucker, A. L., and Bers, D. M. (2008) Phospholemman-mediated activation of Na/K-ATPase limits [Na]i and inotropic state during β-adrenergic stimulation in mouse ventricular myocytes. Circulation 117, 1849-1855
14. Simmerman, H. K., and Jones, L. R. (1998) Phospholamban. Protein structure, mechanism of action, and role in cardiac function. Physiol. Rev. 78, 921-947
15. Simmerman, H. K., Kobayashi, Y. M., Autry, J. M., and Jones, L. R. (1996) Aleucine zipper stabilizes the pentameric membrane domain of phospholamban and forms a coiled-coil pore structure. J. Biol. Chem. 271, 5941-5946
16. 2+ pump and phospholamban in Spodoptera frugiperda (Sf21) cells reveals new insights on ATPase regulation. J. Biol. Chem. 272, 15872-15880
17. Hou, Z., Kelly, E. M., and Robia, S. L. (2008) Phosphomimetic mutations increase phospholamban oligomerization and alter the structure of its regulatory complex. J. Biol. Chem. 283, 28996-29003
18. 2+ pump is sufficient to dissociate phospholamban. J. Biol. Chem. 285, 3253-3260
19. 2+ pump of cardiac sarcoplasmic reticulum to probe spatial and functional interactions within the transmembrane domain. J. Biol. Chem. 281, 14163-14172
20. Bidwell, P., Blackwell, D. J., Hou, Z., Zima, A. V., and Robia, S. L. (2011) Phospholamban binds with differential affinity to calcium pump conformers. J. Biol. Chem. 286, 35044-35050
21. Mueller, B., Karim, C. B., Negrashov, I. V., Kutchai, H., and Thomas, D. D. (2004) Direct detection of phospholamban and sarcoplasmic reticulum Ca-ATPase interaction in membranes using fluorescence resonance energy transfer. Biochemistry 43, 8754-8765
22. Moorman, J. R., Ackerman, S. J., Kowdley, G. C., Griffin, M. P., Mounsey, J. P., Chen, Z., Cala, S. E., O'Brian, J. J., Szabo, G., and Jones, L. R. (1995) Unitary anion currents through phospholemman channel molecules. Nature 377, 737-740
23. Bell, J. R., Lloyd, D., Curl, C. L., Delbridge, L. M., and Shattock, M. J. (2009) Cell volume control in phospholemman (PLM) knockout mice. Do cardiac myocytes demonstrate a regulatory volume decrease and is this influenced by deletion of PLM? Exp. Physiol. 94, 330-343
24. Beevers, A. J., and Kukol, A. (2006) Secondary structure, orientation, and oligomerization of phospholemman, a cardiac transmembrane protein. Protein Sci. 15, 1127-1132
25. Bossuyt, J., Despa, S., Martin, J. L., and Bers, D. M. (2006) Phospholemman phosphorylation alters its fluorescence resonance energy transfer with the Na/K-ATPase pump. J. Biol. Chem. 281, 32765-32773
26. Song, Q., Pallikkuth, S., Bossuyt, J., Bers, D. M., and Robia, S. L. (2011) Phosphomimetic mutations enhance oligomerization of phospholemman and modulate its interaction with the Na/K-ATPase. J. Biol. Chem. 286, 9120-9126
27. Tulloch, L. B., Howie, J., Wypijewski, K. J., Wilson, C. R., Bernard, W. G., Shattock, M. J., and Fuller, W. (2011) The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. J. Biol. Chem. 286, 36020-36031
28. Forrester, M. T., Hess, D. T., Thompson, J. W., Hultman, R., Moseley, M. A., Stamler, J. S., and Casey, P. J. (2011) Site-specific analysis of protein S-acylation by resin-assisted capture. J. Lipid Res. 52, 393-398
29. Oliveros, J. C. (2007) VENNY. An interactive tool for comparing lists with Venn Diagrams. http://bioinfogp.cnb.csic.es/tools/venny/index.html
30. Kinoshita, E., Kinoshita-Kikuta, E., Takiyama, K., and Koike, T. (2006) Phosphate-binding tag, a new tool to visualize phosphorylated proteins. Mol. Cell Proteomics 5, 749-757
31. Howie, J., Tulloch, L. B., Shattock, M. J., and Fuller, W. (2013) Regulation of the cardiac Na(+) pump by palmitoylation of its catalytic and regulatory subunits. Biochem. Soc. Trans. 41, 95-100
32. +-ATPase isoform distribution in rat ventricular myocytes. Am. J. Physiol. Cell Physiol. 293, C321-C327
33. +-ATPase α2-isoform regulates cardiac contractility in rat cardiomyocytes. Cardiovasc. Res. 75, 109-117
34. 2+ release in cardiac myocytes. Cardiovasc. Res. 95, 480-486
35. +-ATPase dictates the concentration of the functional enzyme in caveolae. Am. J. Physiol. Cell Physiol. 291, C569-C578
36. Couet, J., Li, S., Okamoto, T., Ikezu, T., and Lisanti, M. P. (1997) Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J. Biol. Chem. 272, 6525-6533
37. Byrne, D. P., Dart, C., and Rigden, D. J. (2012) Evaluating caveolin interactions. Do proteins interact with the caveolin scaffolding domain through a widespread aromatic residue-rich motif? PLoS One 7, e44879
38. +-ATPase. J. Biol. Chem. 279, 17250-17259
39. Yang, W., Di Vizio, D., Kirchner, M., Steen, H., and Freeman, M. R. (2010) Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes. Mol. Cell Proteomics 9, 54-70
40. Kimura, T., Han, W., Pagel, P., Nairn, A. C., and Caplan, M. J. (2011) Protein phosphatase 2A interacts with the Na, K-ATPase and modulates its trafficking by inhibition of its association with arrestin. PLoS One 6, e29269
41. Lecuona, E., Dada, L. A., Sun, H., Butti, M. L., Zhou, G., Chew, T. L., and Sznajder, J. I. (2006) Na, K-ATPase α1-subunit dephosphorylation by protein phosphatase 2A is necessary for its recruitment to the plasma membrane. FASEB J. 20, 2618-2620
42. El-Armouche, A., Wittköpper, K., Fuller, W., Howie, J., Shattock, M. J., and Pavlovic, D. (2011) Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase. FASEB J. 25, 4467-4475
43. Sutherland, B. W., Toews, J., and Kast, J. (2008) Utility of formaldehyde cross-linking and mass spectrometry in the study of protein-protein interactions. J. Mass Spectrom. 43, 699-715
44. Sargiacomo, M., Scherer, P. E., Tang, Z., Kübler, E., Song, K. S., Sanders, M. C., and Lisanti, M. P. (1995) Oligomeric structure of caveolin. Implications for caveolae membrane organization. Proc. Natl. Acad. Sci. U.S.A. 92, 9407-9411
45. Moshitzky, S., Asher, C., and Garty, H. (2012) Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells. J. Biol. Chem. 287, 21130-21141
46. Bossuyt, J., Ai, X., Moorman, J. R., Pogwizd, S. M., and Bers, D. M. (2005) Expression and phosphorylation of the Na-pump regulatory subunit phospholemman in heart failure. Circ. Res. 97, 558-565
47. +-ATPase E960 and phospholemman F28 are critical for their functional interaction. Proc. Natl. Acad. Sci. U.S.A. 109, 20756-20761
48. + pump mediated by glutathionylation of its α1 subunit. J. Biol. Chem. 286, 18562-18572
49. + pump regulation. Circ. Res. 105, 185-193
50. + channel associates with the glycolytic enzyme complex. FASEB J. 25, 2456-2467
51. Dhar-Chowdhury, P., Malester, B., Rajacic, P., and Coetzee, W. A. (2007) The regulation of ion channels and transporters by glycolytically derived ATP. Cell Mol. Life Sci. 64, 3069-3083
52. +-ATPase. J. Biol. Chem. 286, 32289-32299