Atorvastatin protects against deleterious cardiovascular consequences induced by chronic intermittent hypoxia

Experimental Biology and Medicine

Volumn 238, Issue 2, 2013, Pages 223-232

  Totoson, Perle ^a   Fhayli, Wassim ^a   Faury, Gilles ^a   Korichneva, Irina ^a   Cachot, Sandrine ^a   Baldazza, Marie ^a   Ribuot, Christophe ^a   Pépin, Jean Louis ^a,b   Lévy, Patrick ^a,b   Joyeux Faure, Marie ^a,b  

^a Domaine de la Merci   (France)

^b GRENOBLE UNIVERSITY HOSPITAL   (France)

Author keywords

Atorvastatine; Cardiovascular injuries; Intermittent hypoxia; OAS syndrome; Rat

Indexed keywords

ATORVASTATIN; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTERIAL WALL THICKNESS; ARTERY COMPLIANCE; ARTICLE; BLOOD VESSEL REACTIVITY; BODY WEIGHT; CARDIOVASCULAR DISEASE; CAROTID ARTERY; CHRONIC INTERMITTENT HYPOXIA; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; HEART INFARCTION; HEMATOCRIT; HYPERSENSITIVITY; MALE; NONHUMAN; OXIDATIVE STRESS; PLETHYSMOGRAPHY; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SYSTOLIC BLOOD PRESSURE; WESTERN BLOTTING;

ANIMALS; ANOXIA; ANTICHOLESTEREMIC AGENTS; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; DISEASE MODELS, ANIMAL; HEPTANOIC ACIDS; OXIDATIVE STRESS; PYRROLES; RATS; TREATMENT OUTCOME;

EID: 84877668684     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370212473696     Document Type: Article

References (34)

1. Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002;165:1217-39.
2. Baguet JP, Pepin JL, Hammer L, Levy P, Mallion JM. Cardiovascular consequences of obstructive sleep apnea syndrome. Rev Med Internet 2003;24:530-7.
3. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 2005;353:2034-41.
4. Chung S, Yoon IY, Shin YK, Lee CH, Kim JW, Lee T, Choi DJ, Ahn HJ. Endothelial dysfunction and C-reactive protein in relation with the severity of obstructive sleep apnea syndrome. Sleep 2007;30:997-1001.
5. Jelic S, Le Jemtel TH. Inflammation, oxidative stress, and the vascular endothelium in obstructive sleep apnea. Trends Cardiovasc Med 2008;18:253-60.
6. Gay P, Weaver T, Loube D, Iber C. Evaluation of positive airway pressure treatment for sleep related breathing disorders in adults. Sleep 2006;29:381-401.
7. Joyeux-Faure M, Stanke-Labesque F, Lefebvre B, Beguin P, Godin-Ribuot D, Ribuot C, Launois SH, Bessard G, Levy P. Chronic intermittent hypoxia increases infarction in the isolated rat heart. J Appl Physiol 2005;98:1691-6.
8. Dematteis M, Godin-Ribuot D, Arnaud C, Ribuot C, Stanke-Labesque F, Pepin JL, Levy P. Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding the human disease. Ilar J 2009;50:262-81.
9. Arnaud C, Beguin PC, Lantuejoul S, Pepin JL, Guillermet C, Pelli G, Burger F, Buatois V, Ribuot C, Baguet JP, Mach F, Levy P, Dematteis M. The inflammatory preatherosclerotic remodeling induced by intermittent hypoxia is attenuated by RANTES/CCL5 inhibition. Am J Respir Crit Care Med 2011;184:724-31.
10. Park AM, Suzuki YJ. Effects of intermittent hypoxia on oxidative stress-induced myocardial damage in mice. J Appl Physiol 2007;102:1806-14.
11. Ramond A, Godin-Ribuot D, Ribuot C, Totoson P, Cachot S, Levy P, Joyeux-Faure M. Oxidative stress mediates cardiac infarction aggravation induced by ittermittent hypoxia. Fund Clin Pharmacol 2012 (in press)
12. Maron DJ, Fazio S, Linton MF. Current perspectives on statins. Circulation 2000;101:207-13.
13. Wagner AH, Kohler T, Ruckschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol 2000;20:61-9.
14. Wassmann S, Laufs U, Muller K, Konkol C, Ahlbory K, Baumer AT, Linz W, Bohm M, Nickenig G. Cellular antioxidant effects of atorvastatin in vitro and in vivo. Arterioscler Thromb Vasc Biol 2002;22:300-5.
15. Umeji K, Umemoto S, Itoh S, Tanaka M, Kawahara S, Fukai T, Matsuzaki M. Comparative effects of pitavastatin and probucol on oxidative stress, Cu/Zn superoxide dismutase, PPAR-gamma, and aortic stiffness in hypercholesterolemia. Am J Physiol Heart Circ Physiol 2006;291:H2522-32.
16. Totoson P, Faury G, Cachot S, Baldazza M, Koritchneva I, Ribuot C, Levy P, Joyeux-Faure M. Atorvastatin protective effects against deleterious cardiovascular consequences induced by chronic intermittent hypoxia. Fund Clin Pharmacol 2012;6:90.
17. Totoson P, Faury G, Cachot S, Baldazza S, Koritchneva I, Ribuot C, Levy P, Joyeux-Faure M. Deleterious cardiovascular consequences induced by chronic intermittent hypoxia: role of oxidative stress and protector effect of statin. Arch Cardiovac Dis 2012;3:30.
18. Dery MA, Rousseau G, Benderdour M, Beaumont E. Atorvastatin prevents early apoptosis after thoracic spinal cord contusion injury and promotes locomotion recovery. Neurosci Lett 2009;453:73-6.
19. Stumpf C, Petzi S, Seybold K, Wasmeier G, Arnold M, Raaz D, Yilmaz A, Daniel WG, Garlichs CD. Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction. Clin Sci (Lond) 2009;116:45-52.
20. Mondo CK, Yang WS, Su JZ, Huang TG. Atorvastatin prevented and reversed dexamethasone-induced hypertension in the rat. Clin Exp Hypertens 2006;28:499-509.
21. Imai A, Steffey EP, Farver TB, Ilkiw JE. Assessment of isoflurane-induced anesthesia in ferrets and rats. Am J Vet Res 1999;60:1577-83.
22. Belaidi E, Joyeux-Faure M, Ribuot C, Launois SH, Levy P, Godin-Ribuot D. Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea. J Am Coll Cardiol 2009;53:1309-17.
23. Lochner A, Genade S, Moolman JA. Ischemic preconditioning: infarct size is a more reliable endpoint than functional recovery. Basic Res Cardiol 2003;98:337-46.
24. Philippi NR, Bird CE, Marcus NJ, Olson EB, Chesler NC, Morgan BJ. Time course of intermittent hypoxia-induced impairments in resistance artery structure and function. Respir Physiol Neurobiol 2009;170:157-63.
25. Belaidi E, Ramond A, Joyeux-Faure M, Levy P, Ribuot C, Godin-Ribuot D. Contrasting effects of intermittent hypoxia on myocardial ischemic tolerance. New York: Nova Science Publishers, Inc., 2009:2-18.
26. Zong P, Setty S, Sun W, Martinez R, Tune JD, Ehrenburg IV, Tkatchouk EN, Mallet RT, Downey HF. Intermittent hypoxic training protects canine myocardium from infarction. Exp Biol Med (Maywood) 2004;229:806-12.
27. Jun J, Savransky V, Nanayakkara A, Bevans S, Li J, Smith PL, Polotsky VY. Intermittent hypoxia has organ-specific effects on oxidative stress. Am J Physiol Regul Integr Comp Physiol 2008;295:R1274-1281.
28. Semenza GL. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda) 2009;24:97-106.
29. Semenza GL. Oxygen sensing, homeostasis, and disease. N Engl J Med 2011;365:537-47.
30. Briones AM, Rodriguez-Criado N, Hernanz R, Garcia-Redondo AB, Rodrigues-Diez RR, Alonso MJ, Egido J, Ruiz-Ortega M, Salaices M. Atorvastatin prevents angiotensin II-induced vascular remodeling and oxidative stress. Hypertension 2009;54:142-9.
31. Torrens C, Kelsall CJ, Hopkins LA, Anthony FW, Curzen NP, Hanson MA. Atorvastatin restores endothelial function in offspring of protein-restricted rats in a cholesterol-independent manner. Hypertension 2009;53:661-7.
32. Lavie L, Vishnevsky A, Lavie P. Evidence for lipid peroxidation in obstructive sleep apnea. Sleep 2004;27:123-8.
33. Monneret D, Pepin JL, Godin-Ribuot D, Ducros V, Baguet JP, Levy P, Faure P. Association of urinary 15-F2t-isoprostane level with oxygen desaturation and carotid intima-media thickness in nonobese sleep apnea patients. Free Radic Biol Med 2010;48:619-25.
34. Jurado-Gamez B, Fernandez-Marin MC, Gomez-Chaparro JL, Munoz-Cabrera L, Lopez-Barea J, Perez-Jimenez F, Lopez-Miranda J. Relationship of oxidative stress and endothelial dysfunction in sleep apnoea. Eur Respir J 2011;37:873-9