Improved neural differentiation of human mesenchymal stem cells interfaced with carbon nanotube scaffolds

Nanomedicine

Volumn 8, Issue 5, 2013, Pages 715-723

  Park, Sung Young ^a,b   Kang, Byung Soo ^a   Hong, Seunghun ^a  

^a Seoul National University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

carbon nanotube; mesenchymal stem cell; neural differentiation; neural gene expression; voltage dependent ion channel

Indexed keywords

ION CHANNEL; SINGLE WALLED NANOTUBE; SODIUM CHANNEL NAV1.1; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; ARTIFICIAL NEURAL NETWORK; CELL CULTURE; CELL ELONGATION; CELL GROWTH; CELL STRUCTURE; CONTROLLED STUDY; FILM; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MESENCHYMAL STEM CELL; NERVE CELL DIFFERENTIATION; NUCLEAR SHAPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

CALCIUM CHANNELS; CELL LINE; CELL PROLIFERATION; CELL SHAPE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MESENCHYMAL STROMAL CELLS; NANOTUBES, CARBON; NEUROGENESIS; POTASSIUM CHANNELS, VOLTAGE-GATED; TISSUE SCAFFOLDS; VOLTAGE-GATED SODIUM CHANNELS;

EID: 84877647395     PISSN: 17435889     EISSN: 17486963     Source Type: Journal    
DOI: 10.2217/nnm.12.143     Document Type: Article

References (28)

1. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143-147 (1999).
2. Hofstetter CP, Schwarz EJ, Hess D et al. Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery. Proc. Natl Acad. Sci. USA 99, 2199-2204 (2002).
3. Cho KJ, Trzaska KA, Greco SJ et al. Neurons derived from human mesenchymal stem cells show synaptic transmission and can be induced to produce the neurotransmitter substance P by interleukin-1 alpha. Stem Cells 23, 383-391 (2005).
4. Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J. Neurosci. Res. 61, 364-370 (2000).
5. Tondreau T, Dejeneffe M, Meuleman N et al. Gene expression pattern of functional neuronal cells derived from human bone marrow mesenchymal stromal cells. BMC Genomics 9, 166 (2008).
6. Qian L, Saltzman WM. Improving the expansion and neuronal differentiation of mesenchymal stem cells through culture surface modification. Biomaterials 25, 1331-1337 (2004).
7. Yim EK, Pang SW, Leong KW. Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage. Exp. Cell. Res. 313, 1820-1829 (2007).
8. Tay CY, Yu H, Pal M et al. Micropatterned matrix directs differentiation of human mesenchymal stem cells towards myocardial lineage. Exp. Cell. Res. 316, 1159-1168 (2010).
9. Lee YS, Collins G, Arinzeh TL. Neurite extension of primary neurons on electrospun piezoelectric scaffolds. Acta Biomaterial. 7, 3877-3886 (2011).
10. Lee YS, Arinzeh TL. Electrospun nanofibrous materials for neural tissue engineering. Polymers 3, 413-426 (2011).
11. Yokoi H, Kinoshita T, Zhang S. Dynamic reassembly of peptide RADA16 nanofiber scaffold. Proc. Natl Acad. Sci. USA 102, 8414-8419 (2005).
12. Chao TI, Xiang S, Lipstate JF, Wang C, Lu J. Poly(methacrylic acid)-grafted carbon nanotube scaffolds enhance differentiation of hESCs into neuronal cells. Adv. Mater. 22, 3542-3547 (2010).
13. Tay CY, Gu H, Leong WS et al. Cellular behavior of human mesenchymal stem cells cultured on single-walled carbon nanotube film. Carbon 48, 1095-1104 (2010).
14. Park SY, Choi DS, Jin HJ et al. Polarization-controlled differentiation of human neural stem cells using synergistic cues from the patterns of carbon nanotube monolayer coating. ACS Nano 5, 4704-4711 (2011).
15. Rao SG, Huang L, Setyawan W, Hong S. Nanotube electronics: large-scale assembly of carbon nanotubes. Nature 425, 36-37 (2003).
16. Baik KY, Park SY, Heo K, Lee KB, Hong S. Carbon nanotube monolayer cues for osteogenesis of mesenchymal stem cells. Small 7, 741-745 (2011).
17. Park SY, Park SY, Namgung S et al. Carbon nanotube monolayer patterns for directed growth of mesenchymal stem cells. Adv. Mater. 19, 2530-2534 (2007).
18. Heubach JF, Graf EM, Leutheuser J et al. Electrophysiological properties of human mesenchymal stem cells. J. Physiol. 554, 659-672 (2004).
19. Jelitai M, Anderova M, Chvatal A, Madarasz E. Electrophysiological characterization of neural stem/progenitor cells during in vitro differentiation: study with an immortalized neuroectodermal cell line. J. Neurosci. Res. 85, 1606-1617 (2007).
20. Yasuda T, Adams DJ. Physiological roles of ion channels in adult neural stem cells and their progeny. J. Neurochem. 114, 946-959 (2010).
21. Schaarschmidt G, Wegner F, Schwarz SC, Schmidt H, Schwarz J. Characterization of voltage-gated potassium channels in human neural progenitor cells. PLoS ONE 4, e6168 (2009).
22. Shibata R, Nakahira K, Shibasaki K, Wakazono Y, Imoto K, Ikenaka K. A-type K+ current mediated by the Kv4 channel regulates the generation of action potential in developing cerebellar granule cells. J. Neurosci. 20, 4145-4155 (2000).
23. Mareschi K, Novara M, Rustichelli D et al. Neural differentiation of human mesenchymal stem cells: evidence for expression of neural markers and eag K+ channel types. Exp. Hematol. 34, 1563-1572 (2006).
24. Armstrong CM, Hille B. Voltage gated ion channels and electrical excitability. Neuron 20, 371-380 (1998).
25. Holmes TC, de Lacalle S, Su X, Liu G, Rich A, Zhang S. Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds. Proc. Natl Acad. Sci. USA 97, 6728-6733 (2000).
26. Ellis-Behnke RG, Liang YX, You SW et al. Nano neuro knitting: peptide nanofiber scaffold for brain repair and axon regeneration with functional return of vision. Proc. Natl Acad. Sci. USA 103, 5054-5059 (2006).
27. Cellot G, Cilia E, Cipollone S et al. Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts. Nat. Nanotechnol. 4, 126-133 (2009).
28. ImageJ: Image processing and analysis in Java. http://rsbweb.nih.gov/ij/