The link between enthesitis and arthritis in psoriatic arthritis: A switch to a vascular phenotype at insertions may play a role in arthritis development

Annals of the Rheumatic Diseases

Volumn 72, Issue 6, 2013, Pages 992-995

  Aydin, Sibel Z ^a   Ash, Zoe R ^b   Tinazzi, Ilaria ^c   Castillo Gallego, Concepción ^d   Kwok, Chung ^e   Wilson, Caroline ^e   Goodfield, Mark ^e   Gisondi, Paolo ^f   Tan, Ai Lyn ^b   Marzo Ortega, Helena ^b   Emery, Paul ^b   Wakefield, Richard J ^b   McGonagle, Dennis G ^b  

^a GOZTEPE TRAINING AND RESEARCH HOSPITAL   (Turkey)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c UNIVERSITY OF VERONA   (Italy)

^d HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^e LEEDS TEACHING HOSPITALS NHS TRUST   (United Kingdom)

^f UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ASYMPTOMATIC DISEASE; CLINICAL ASSESSMENT; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DOPPLER ECHOGRAPHY; ENTHESITIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PSORIASIS; PSORIATIC ARTHRITIS; VASCULARIZATION;

INFLAMMATION; PSORIATIC ARTHRITIS; ULTRASONOGRAPHY;

ADULT; ARTHRITIS, PSORIATIC; CASE-CONTROL STUDIES; FEMALE; HUMANS; LOWER EXTREMITY; MALE; MIDDLE AGED; PHENOTYPE; PSORIASIS; RHEUMATIC DISEASES; ULTRASONOGRAPHY, DOPPLER;

EID: 84877621704     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2012-201617     Document Type: Article

References (24)

1. McGonagle D, Conaghan PG, Emery P. Psoriatic arthritis: a unified concept twenty years on. Arthritis Rheum 1999;42:1080-6. (Pubitemid 29268943)
2. Balint PV, Kane D, Wilson H, et al. Ultrasonography of entheseal insertions in the lower limb in spondyloarthropathy. Ann Rheum Dis 2002;61:905-10.
3. Wakefield RJ, Green MJ, Marzo-Ortega H, et al. Should oligoarthritis be reclassified? Ultrasound reveals a high prevalence of subclinical disease. Ann Rheum Dis 2004;63:382-5. (Pubitemid 38453303)
4. McGonagle D, Ash Z, Dickie L, et al. The early phase of psoriatic arthritis. Ann Rheum Dis 2011;70(Suppl. 1):i71-6.
5. Wakefield RJ, Balint PV, Szkudlarek M, et al. Musculoskeletal ultrasound including definitions for ultrasonographic pathology. J Rheumatol 2005;32:2485-7. (Pubitemid 41780675)
6. Kurosaka D, Hirai K, Nishioka M, et al. Clinical significance of serum levels of vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in patients with rheumatoid arthritis. J Rheumatol 2010;37:1121-8.
7. Naredo E, Moller I, Cruz A, et al. Power Doppler ultrasonographic monitoring of response to anti-tumor necrosis factor therapy in patients with rheumatoid arthritis. Arthritis Rheum 2008;58:2248-56.
8. Aydin SZ, Karadag O, Filippucci E, et al. Monitoring Achilles enthesitis in ankylosing spondylitis during TNF-alpha antagonist therapy: an ultrasound study. Rheumatology (Oxford) 2010;49:578-82.
9. Hammer H, Kvien T. Ultrasonography shows significant improvement in wrist and ankle tenosynovitis in rheumatoid arthritis patients treated with adalimumab. Scand J Rheumatol 2011;40:178-82.
10. Fournie B, Margarit-Coll N, Champetier de Ribes TL, et al. Extrasynovial ultrasound abnormalities in the psoriatic finger. Prospective comparative power-doppler study versus rheumatoid arthritis. Joint Bone Spine 2006;73:527-31. (Pubitemid 44848044)
11. Gutierrez M, Filippucci E, De Angelis R, et al. Subclinical entheseal involvement in patients with psoriasis: an ultrasound study. Semin Arthritis Rheum 2011;40:407-12.
12. Gutierrez M, Filippucci E, Salaffi F, et al. Differential diagnosis between rheumatoid arthritis and psoriatic arthritis: the value of ultrasound findings at metacarpophalangeal joints level. Ann Rheum Dis 2011;70:1111-14.
13. Ash ZR, Tinazzi I, Gallego CC, et al. Psoriasis patients with nail disease have a greater magnitude of underlying systemic subclinical enthesopathy than those with normal nails. Ann Rheum Dis 2012;71:553-6.
14. Taylor W, Gladman D, Helliwell P, et al. Classification criteria for psoriatic arthritis: development of new criteria from a large international study. Arthritis Rheum 2006;54:2665-73. (Pubitemid 44205029)
15. Benjamin M, McGonagle D. The enthesis organ concept and its relevance to the spondyloarthropathies. Adv Exp Med Biol 2009;649:57-70.
16. Reece RJ, Canete JD, Parsons WJ, et al. Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis. Arthritis Rheum 1999;42:1481-4. (Pubitemid 30265607)
17. Fearon U, Griosios K, Fraser A, et al. Angiopoietins, growth factors, and vascular morphology in early arthritis. J Rheumatol 2003;30:260-8. (Pubitemid 36152587)
18. Zaric D, Clemmensen OJ, Worm AM, et al. Capillary microscopy of the nail fold in patients with psoriasis and psoriatic arthritis. Dermatologica 1982;164:10-14. (Pubitemid 12165726)
19. Creamer D, Allen MH, Sousa A, et al. Localization of endothelial proliferation and microvascular expansion in active plaque psoriasis. Br J Dermatol 1997;136:859-65. (Pubitemid 27283516)
20. Benjamin M, Toumi H, Suzuki D, et al. Microdamage and altered vascularity at the enthesis-bone interface provides an anatomic explanation for bone involvement in the HLA-B27-associated spondylarthritides and allied disorders. Arthritis Rheum 2007;56:224-33. (Pubitemid 46106196)
21. Naredo E, Moller I, de Miguel E, et al. High prevalence of ultrasonographic synovitis and enthesopathy in patients with psoriasis without psoriatic arthritis: a prospective case-control study. Rheumatology (Oxford) 2011;50:1838-48.
22. de Miguel E, Munoz-Fernandez S, Castillo C, et al. Diagnostic accuracy of enthesis ultrasound in the diagnosis of early spondyloarthritis. Ann Rheum Dis 2011;70:434-9.
23. Gisondi P, Tinazzi I, El-Dalati G, et al. Lower limb enthesopathy in patients with psoriasis without clinical signs of arthropathy: a hospital-based case-control study. Ann Rheum Dis 2008;67:26-30.
24. Tinazzi I, McGonagle D, Biasi D, et al. Preliminary evidence that subclinical enthesopathy may predict psoriatic arthritis in patients with psoriasis. J Rheumatol 2011;38:2691-2.