Altered MicroRNA expression in the Ischemic-Reperfusion spinal cord with atorvastatin therapy

Journal of Pharmacological Sciences

Volumn 121, Issue 4, 2013, Pages 343-346

  Hu, Jia Rui ^a   Lv, Guo Hua ^a   Yin, Bang Liang ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Atorvastatin; Ischemia reperfusion injury; MicroRNA

Indexed keywords

ATORVASTATIN; MICRORNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; GENE EXPRESSION; INFLAMMATION; NEUROPROTECTION; NONHUMAN; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; SPINAL CORD INJURY; UPREGULATION;

EID: 84877618350     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.12235SC     Document Type: Article

References (15)

1. Satoh J. MicroRNAs and their therapeutic potential for human diseases: aberrant microRNA expression in Alzheimer's disease brains. J Pharmacol Sci. 2010;114:269-275.
2. Nakanishi K, Nakasa T, Tanaka N, Ishikawa M, Yamada K, Yamasaki K, et al. Responses of microRNAs 124a and 223 following spinal cord injury in mice. Spinal Cord. 2010;48: 192-196.
3. Yunta M, Nieto-Díaz M, Esteban FJ, Caballero-López M, Navarro-Ruíz R, Reigada D, et al. MicroRNA dysregulation in the spinal cord following traumatic injury. PLoS One. 2012;7: e34534.
4. Taira Y, Marsala M. Effect of proximal arterial perfusion pressure on function, spinal cord blood flow, and histopathologic changes after increasing intervals of aortic occlusion in the rat. Stroke. 1996;27:1850-1858.
5. Godwin JG, Ge X, Stephan K, Jurisch A, Tullius SG, Iacomini J. Identification of a microRNA signature of renal ischemia reperfusion injury. Proc Natl Acad Sci U S A. 2010;107:14339- 14344.
6. Shichita T, Sakaguchi R, Suzuki M, Yoshimura A. Post-ischemic inflammation in the brain. Front Immunol. 2012;3:132.
7. Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, et al. Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med. 2012;18: 911-917.
8. Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004;4:499-511.
9. Li X, Gibson G, Kim JS, Kroin J, Xu S, van Wijnen AJ, et al. MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene. 2011;480:34-41.
10. Chen R, Alvero AB, Silasi DA, Kelly MG, Fest S, Visintin I, et al. Regulation of IKKbeta by miR-199a affects NF-kappaB activity in ovarian cancer cells. Oncogene. 2008;27:4712-4723.
11. Kim S, Lee UJ, Kim MN, Lee EJ, Kim JY, Lee MY, et al. MicroRNA miR-199a regulates the MET proto-oncogene and the downstream extracellular signal-regulated kinase 2 (ERK2). J Biol Chem. 2008;283:18158-18166.
12. Rane S, He M, Sayed D, Vashistha H, Malhotra A, Sadoshima J, et al. Downregulation of miR-199a derepresses hypoxiainducible factor-1alpha and Sirtuin 1 and recapitulates hypoxia preconditioning in cardiac myocytes. Circ Res. 2009;104:879- 886.
13. Die J, Wang K, Fan L, Jiang Y, Shi Z. Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions. Brain Res. 2010;1346:251-261.
14. Ucak A, Onan B, Guler A, Sahin MA, Kiliçkaya O, Oztaş E, et al. Rosuvastatin, a new generation 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, reduces ischemia/reperfusioninduced spinal cord tissue injury in rats. Ann Vasc Surg. 2011; 25:686-695.
15. Saito T, Tsuchida M, Umehara S, Kohno T, Yamamoto H, Hayashi J. Reduction of spinal cord ischemia/reperfusion injury with simvastatin in rats. Anesth Analg. 2011;113:565-571.