Effect of aliskiren on proteinuria in non-diabetic chronic kidney disease: A double-blind, crossover, randomised, controlled trial

International Urology and Nephrology

Volumn 44, Issue 6, 2012, Pages 1763-1770

  Lizakowski, Sławomir ^a   Tylicki, Leszek ^a   Renke, Marcin ^a   Rutkowski, Przemysław ^a   Heleniak, Zbigniew ^a   Sławińska Morawska, Maja ^a   Aleksandrowicz, Ewa ^a   Łysiak Szydłowska, Wieslawa ^a   Rutkowski, Bolesław ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

ACE inhibitor; Aliskiren; Chronic kidney diseases; Proteinuria; Renin inhibitor

Indexed keywords

ALISKIREN; PERINDOPRIL; PLACEBO; AMIDE; FUMARIC ACID DERIVATIVE; RENIN;

ARTICLE; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CREATININE CLEARANCE; CROSSOVER PROCEDURE; DISEASE ASSOCIATION; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; KIDNEY FUNCTION; MALE; POTASSIUM BLOOD LEVEL; PROTEIN INTAKE; PROTEINURIA; SIDE EFFECT; SODIUM INTAKE; ADULT; BLOOD PRESSURE; CHRONIC KIDNEY FAILURE; CONTROLLED CLINICAL TRIAL; DRUG ANTAGONISM; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL;

ADULT; AMIDES; BLOOD PRESSURE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; FUMARATES; HUMANS; MALE; PROTEINURIA; RENAL INSUFFICIENCY, CHRONIC; RENIN;

MLCS; MLOWN;

EID: 84877616196     PISSN: 03011623     EISSN: 15732584     Source Type: Journal    
DOI: 10.1007/s11255-011-0110-z     Document Type: Article

References (24)

1. Remuzzi G, Bertani T (1990) Is glomerulosclerosis a consequence of altered glomerular permeability to macromolecules? Kidney Int 38:384-394
2. Nakamura T, Fujiwara N, Sato E, Ueda Y, Sugaya T, Koide H (2010) Renoprotective effects of various angiotensin II receptor blockers in patients with early-stage diabetic nephropathy. Kidney Blood Press Res 33:213-220
3. Tylicki L, Larczynski W, Rutkowski B (2005) Renal protective effects of the renin-angiotensin-aldosterone system blockade: from evidence-based approach to perspectives. Kidney Blood Press Res 28:230-242
4. Siamopoulos KC, Kalaitzidis RG (2008) Inhibition of the renin-angiotensin system and chronic kidney disease. Int Urol Nephrol 40:1015-1025
5. The GISEN group (Gruppo Italiano di Studi Epidemiologici in Nefrologia) (1997) Randomised placebo-controlled trial of effects of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. Lancet 349:1857-1863
6. Maschio G, Alberti D, Janin G, et al. (1996) Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. The angiotensin-converting-enzyme inhibition in progressive renal insufficiency study group. N Engl J Med 334:939-945
7. Tylicki L, Rutkowski P, Renke M, Rutkowski B (2002) Renoprotective effect of small doses of losartan and enalapril in patients with primary glomerulonephritis. Am J Nephrol 22:356-362
8. Nussberger J, Wuerzner G, Jensen C, Brunner HR (2002) Angiotensin II suppression in humans by the orally active renin inhibitor Aliskiren (SPP100): comparison with enalapril. Hypertension 39:E1-E8
9. Gradman AH, Schmieder RE, Lins RL, Nussberger J, Chiang Y, Bedigian MP (2005) Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and placebo-like tolerability in hypertensive patients. Circulation 111:1012-1018
10. Stanton A, Jensen C, Nussberger J, O'Brien E (2003) Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. Hypertension 42:1137-1143
11. Parving HH, Persson F, Lewis JB, Lewis EJ, Hollenberg NK (2008) Aliskiren combined with losartan in type 2 diabetes and nephropathy. N Engl J Med 358:2433-2446
12. Persson F, Rossing P, Schjoedt KJ, et al. (2008) Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes. Kidney Int 73:1419-1425
13. Tang SC, Lin M, Tam S, et al. (2011) Aliskiren combined with losartan in immunoglobulin a nephropathy: an open-labeled pilot study. Nephrol Dial Transplant. doi:10.1093/ndt/gfr349
14. Moriyama T, Tsuruta Y, Kojima C, et al. (2011) Beneficial effect of aliskiren combined with olmesartan in reducing urinary protein excretion in patients with chronic kidney disease. Int Urol Nephrol. doi:10.1007/s11255-011- 9991-0
15. Chrysant SG, McDonald RH, Wright JT, Barden PL, Weiss RJ (1993) Perindopril as monotherapy in hypertension: a multicenter comparison of two dosing regimens. The perindopril study group. Clin Pharmacol Ther 53:479-484
16. Bianchi S, Bigazzi R, Campese VM (2005) Antagonists of aldosterone and proteinuria in patients with CKD: an uncontrolled pilot study. Am J Kidney Dis 36:45-51
17. Grubbs FE (1969) Procedures for detecting outlying observations. Technometrics 11:1-21
18. Feldman DL, Jin L, Xuan H, et al. (2008) Effects of aliskiren on blood pressure, albuminuria, and (pro)renin receptor expression in diabetic TG(mRen-2)27 rats. Hypertension 52:130-136
19. Pilz B, Shagdarsuren E, Wellner M, et al. (2005) Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension 46:569-576
20. Kelly DJ, Zhang Y, Moe G, Naik G, Gilbert RE (2007) Aliskiren, a novel renin inhibitor, is renoprotective in a model of advanced diabetic nephropathy in rats. Diabetologia 50:2398-2404
21. Persson F, Rossing P, Reinhard H, et al. (2009) Renal effects of aliskiren compared with and in combination with irbesartan in patients with type 2 diabetes, hypertension, and albuminuria. Diabetes Care 32:1873-1879
22. Uresin Y, Taylor AA, Kilo C, et al. (2007) Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J Renin Angiotensin Aldosterone Syst 8:190-198
23. Andersen K, Weinberger MH, Egan B, et al. (2008) Comparative efficacy and safety of aliskiren, an oral direct renin inhibitor, and ramipril in hypertension: a 6-month, randomized, double-blind trial. J Hypertens 26:589-599
24. Fisher ND, Jan Danser AH, Nussberger J, Dole WP, Hollenberg NK (2008) Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans. Circulation 117:3199-3205