Retinal Pigmented Epithelial Cells Cytotoxicity and Apoptosis through Activation of the Mitochondrial Intrinsic Pathway: Role Of Indocyanine Green, Brilliant Blue and Implications for Chromovitrectomy

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Penha, Fernando M ^a   Pons, Marianne ^b   Costa, Elaine Fiod ^a   Barros, Nilana Meza Tenório ^a   Rodrigues, Eduardo B ^a   Cardoso, Emmerson Badaró ^a   Dib, Eduardo ^a   Maia, Mauricio ^a   Marin Castaño, Maria E ^b   Farah, Michel Eid ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID VIOLET; BRILLIANT BLUE; CASPASE 9; CYTOCHROME C; DYE; INDOCYANINE GREEN; MESSENGER RNA; METHYLENE BLUE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BAX GENE; CASPASE 9 GENE; CELL COUNT; CELL VIABILITY; CHROMOVITRECTOMY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOCHROME C GENE; CYTOTOXICITY; ENZYME ACTIVATION; EYE TOXICITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; VITRECTOMY; WESTERN BLOTTING;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZENESULFONATES; CASPASE 9; CELL LINE; CELL SURVIVAL; COLORING AGENTS; CYTOCHROMES C; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; INDOCYANINE GREEN; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION;

EID: 84877615069     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064094     Document Type: Article

References (46)

1. Yooh HS, Brooks HL Jr, Capone A Jr, L'Hernault NL, Grossniklaus HE, (1996) Ultrastructural features of tissue removed during idiopathic macular hole surgery. Am J Ophthalmol 122: 67-75.
2. Maia M, Haller JA, Pieramici DJ, Margalit E, de Juan E Jr, et al. (2004) Retinal pigment epithelial abnormalities after internal limiting membrane peeling guided by indocyanine green staining. Retina 24: 157-160.
3. Smiddy WE, (1996) The current status of macular hole surgery. Bull Soc Belge Ophtalmol 262: 31-42.
4. Rodrigues EB, Costa EF, Penha FM, Melo GB, Bottos J, et al. (2009) The use of vital dyes in ocular surgery. Surv Ophthalmol 54: 576-617.
5. Burk SE, Da Mata AP, Snyder ME, Rosa RH Jr, Foster RE, (2000) Indocyanine green-assisted peeling of the retinal internal limiting membrane. Ophthalmology 107: 2010-2014.
6. Penha FM, Maia M, Farah ME, Dib E, Principe AH, et al. (2008) Morphologic and clinical effects of subretinal injection of indocyanine green and infracyanine green in rabbits. J Ocul Pharmacol Ther 24: 52-61.
7. Penha FM, Maia M, Eid Farah M, Principe AH, Freymuller EH, et al. (2007) Effects of subretinal injections of indocyanine green, trypan blue, and glucose in rabbit eyes. Ophthalmology 114: 899-908.
8. Maia M, Margalit E, Lakhanpal R, Tso MO, Grebe R, et al. (2004) Effects of intravitreal indocyanine green injection in rabbits. Retina 24: 69-79.
9. Maia M, Kellner L, de Juan E Jr, Smith R, Farah ME, et al. (2004) Effects of indocyanine green injection on the retinal surface and into the subretinal space in rabbits. Retina 24: 80-91.
10. Li K, Wong D, Hiscott P, Stanga P, Groenewald C, et al. (2003) Trypan blue staining of internal limiting membrane and epiretinal membrane during vitrectomy: visual results and histopathological findings. Br J Ophthalmol 87: 216-219.
11. Haritoglou C, Gandorfer A, Schaumberger M, Priglinger SG, Mueller AJ, et al. (2004) Trypan blue in macular pucker surgery: an evaluation of histology and functional outcome. Retina 24: 582-590.
12. Feron EJ, Veckeneer M, Parys-Van Ginderdeuren R, Van Lommel A, Melles GR, et al. (2002) Trypan blue staining of epiretinal membranes in proliferative vitreoretinopathy. Arch Ophthalmol 120: 141-144.
13. Meyer CH, Rodrigues EB, Kroll P (2004) Trypan blue has a high affinity to cellular structures such as epiretinal membrane. Am J Ophthalmol 137: 207-208; author reply 208.
14. Vote BJ, Russell MK, Joondeph BC, (2004) Trypan blue-assisted vitrectomy. Retina 24: 736-738.
15. Narayanan R, Kenney MC, Kamjoo S, Trinh TH, Seigel GM, et al. (2005) Trypan blue: effect on retinal pigment epithelial and neurosensory retinal cells. Invest Ophthalmol Vis Sci 46: 304-309.
16. Maia M, Penha F, Rodrigues EB, Principe A, Dib E, et al. (2007) Effects of subretinal injection of patent blue and trypan blue in rabbits. Curr Eye Res 32: 309-317.
17. Luke M, Januschowski K, Beutel J, Luke C, Grisanti S, et al. (2008) Electrophysiological effects of Brilliant Blue G in the model of the isolated perfused vertebrate retina. Graefes Arch Clin Exp Ophthalmol 246: 817-822.
18. Rodrigues EB, Penha FM, Farah ME, de Paula Fiod Costa E, Maia M, et al. (2009) Preclinical investigation of the retinal biocompatibility of six novel vital dyes for chromovitrectomy. Retina 29: 497-510.
19. Rodrigues EB, Penha FM, de Paula Fiod Costa E, Maia M, Dib E, et al. (2010) Ability of new vital dyes to stain intraocular membranes and tissues in ocular surgery. Am J Ophthalmol 149: 265-277.
20. Malerbi FK, Maia M, Farah ME, Rodrigues EB, (2009) Subretinal brilliant blue G migration during internal limiting membrane peeling. Br J Ophthalmol 93: 1687.
21. Sayanagi K, Ikuno Y, Soga K, Sawa M, Oshima Y, et al. (2007) Residual indocyanine green fluorescence pattern after vitrectomy for idiopathic macular hole with internal limiting membrane peeling. Br J Ophthalmol 91: 939-944.
22. Nachlas MM, Margulies SI, Goldberg JD, Seligman AM, (1960) The determination of lactic dehydrogenase with a tetrazolium salt. Anal Biochem 1: 317-326.
23. Liu X, Kim CN, Yang J, Jemmerson R, Wang X, (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86: 147-157.
24. Vaux DL, (1997) CED-4 - the third horseman of apoptosis. Cell 90: 389-390.
25. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X, (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90: 405-413.
26. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, et al. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489.
27. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, et al. (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730.
28. Hsu YT, Wolter KG, Youle RJ, (1997) Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proc Natl Acad Sci U S A 94: 3668-3672.
29. Rosse T, Olivier R, Monney L, Rager M, Conus S, et al. (1998) Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c. Nature 391: 496-499.
30. Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, et al. (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 95: 4997-5002.
31. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, et al. (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275: 1129-1132.
32. Oltvai ZN, Milliman CL, Korsmeyer SJ, (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619.
33. Parone PA, James D, Martinou JC, (2002) Mitochondria: regulating the inevitable. Biochimie 84: 105-111.
34. Stanescu-Segall D, Jackson TL, (2009) Vital staining with indocyanine green: a review of the clinical and experimental studies relating to safety. Eye (Lond) 23: 504-518.
35. Jackson TL, Hillenkamp J, Knight BC, Zhang JJ, Thomas D, et al. (2004) Safety testing of indocyanine green and trypan blue using retinal pigment epithelium and glial cell cultures. Invest Ophthalmol Vis Sci 45: 2778-2785.
36. Beutel J, Dahmen G, Ziegler A, Hoerauf H, (2007) Internal limiting membrane peeling with indocyanine green or trypan blue in macular hole surgery: a randomized trial. Arch Ophthalmol 125: 326-332.
37. Christensen UC, Kroyer K, Sander B, Larsen M, Henning V, et al. (2009) Value of internal limiting membrane peeling in surgery for idiopathic macular hole stage 2 and 3: a randomised clinical trial. Br J Ophthalmol 93: 1005-1015.
38. Hillenkamp J, Saikia P, Herrmann WA, Framme C, Gabel VP, et al. (2007) Surgical removal of idiopathic epiretinal membrane with or without the assistance of indocyanine green: a randomised controlled clinical trial. Graefes Arch Clin Exp Ophthalmol 245: 973-979.
39. Haritoglou C, Priglinger S, Liegl R, May CA, Eibl K, et al. (2009) Experimental evaluation of aniline and methyl blue for intraocular surgery. Retina 29: 1266-1273.
40. Thaler S, Schuettauf F, Fiedorowicz M, Messias A, Schatz A, et al. (2009) In vivo toxicity testing of methyl blue and aniline blue as vital dyes for intraocular surgery. Retina 29: 1257-1265.
41. Enaida H, Ishibashi T, (2008) Brilliant blue in vitreoretinal surgery. Dev Ophthalmol 42: 115-125.
42. Sayanagi K, Ikuno Y, Soga K, Sawa M, Tano Y (2007) Residual Indocyanine Green Fluorescence Pattern after Vitrectomy with Internal Limiting Membrane Peeling in High Myopia. Am J Ophthalmol.
43. Kimbler DE, Shields J, Yanasak N, Vender JR, Dhandapani KM, (2012) Activation of P2X7 promotes cerebral edema and neurological injury after traumatic brain injury in mice. PLoS One 7: e41229.
44. Balaiya S, Brar VS, Murthy RK, Chalam KV, (2011) Comparative in vitro safety analysis of dyes for chromovitrectomy: indocyanine green, brilliant blue green, bromophenol blue, and infracyanine green. Retina 31: 1128-1136.
45. Riedl SJ, Salvesen GS, (2007) The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol 8: 405-413.
46. Costa EF, Barros NM, Coppini LP, Neves RL, Carmona AK, et al. (2013) Effects of Light Exposure, pH, Osmolarity, and Solvent on the Retinal Pigment Epithelial Toxicity of Vital Dyes. Am J Ophthalmol 155: 705-712 e701.