The effect of intravertebral heterogeneity in microstructure on vertebral strength and failure patterns

Osteoporosis International

Volumn 24, Issue 3, 2013, Pages 979-989

  Hussein, A I ^a   Morgan, E F ^a  

^a Boston University   (United States)

Author keywords

Bone strength; Computed tomography; Failure patterns; Residual strain; Trabecular structure; Vertebra

Indexed keywords

AGED; ANATOMICAL VARIATION; ANATOMY; ANISOTROPY; ARTICLE; BONE DENSITY; BONE STRENGTH; BONE TISSUE; FEMALE; GENETIC HETEROGENEITY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; INTRAVERTEBRAL HETEROGENEITY; MALE; MECHANICAL TORSION; MUSCULOSKELETAL STIFFNESS; PRIORITY JOURNAL; SPINE FRACTURE; TISSUE DISTRIBUTION; TRABECULAR BONE; VERTEBRA; VERTEBRA BODY; VERTEBRA COMPRESSION; VERTEBRA MALFORMATION;

AGED; AGED, 80 AND OVER; BONE DENSITY; COMPRESSIVE STRENGTH; ELASTICITY; FEMALE; HUMANS; MALE; SHEAR STRENGTH; STRESS, MECHANICAL; THORACIC VERTEBRAE; X-RAY MICROTOMOGRAPHY;

EID: 84877611765     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-012-2039-1     Document Type: Article

References (41)

1. O'Neill TW, Felsenberg D, Varlow J, Cooper C, Kanis JA, Silman AJ (1996) The prevalence of vertebral deformity in european men and women: the European Vertebral Osteoporosis Study. J Bone Miner Res 11(7):1010-1018
2. Roux C, Fechtenbaum J, Kolta S, Briot K, Girard M (2007) Mild prevalent and incident vertebral fractures are risk factors for new fractures. Osteoporos Int 18(12):1617-1624. doi: 10.1007/s00198-007-0413-1
3. Melton LJ III, Atkinson EJ, Cooper C, O'Fallon WM, Riggs BL (1999) Vertebral fractures predict subsequent fractures. Osteoporos Int 10(3):214-221. doi: 10.1007/s001980050218
4. Cheng XG, Nicholson PH, Boonen S, Lowet G, Brys P, Aerssens J, Van der Perre G, Dequeker J (1997) Prediction of vertebral strength in vitro by spinal bone densitometry and calcaneal ultrasound. J Bone Miner Res 12(10):1721-1728
5. Cann C (1988) Quantitative CT for determination of bone mineral density: a review. Radiology 166:509-522
6. Kanis JA, Johnell O, Oden A, De Laet C, Jonsson B, Dawson A (2002) Ten-year risk of osteoporotic fracture and the effect of risk factors on screening strategies. Bone 30(1):251-258
7. Eswaran SK, Gupta A, Adams MF, Keaveny TM (2006) Cortical and trabecular load sharing in the human vertebral body. J Bone Miner Res 21(2):307-314. doi: 10.1359/jbmr.2006.21.2.307
8. Cody DD, Goldstein SA, Flynn MJ, Brown EB (1991) Correlations between vertebral regional bone mineral density (rBMD) and whole bone fracture load. Spine 16(2):146-154
9. McCubbrey DA, Cody DD, Peterson EL, Kuhn JL, Flynn MJ, Goldstein SA (1995) Static and fatigue failure properties of thoracic and lumbar vertebral bodies and their relation to regional density. J Biomech 28(8):891-899
10. Yerramshetty J, Kim DG, Yeni YN (2009) Increased microstructural variability is associated with decreased structural strength but with increased measures of structural ductility in human vertebrae. J Biomech Eng 131:094501
11. Wegrzyn J, Roux JP, Arlot ME, Boutroy S, Vilayphiou N, Guyen O, Delmas PD, Chapurlat R, Bouxsein ML (2010) Role of trabecular microarchitecture and its heterogeneity parameters in the mechanical behavior of ex vivo human L3 vertebrae. J Bone Miner Res 25(11):2324-2331
12. Banse X, Devogelaer JP, Munting E, Delloye C, Cornu O, Grynpas M (2001) Inhomogeneity of human vertebral cancellous bone: systematic density and structure patterns inside the vertebral body. Bone 28(5):563-571
13. Nepper-Rasmussen J, Mosekilde L (1989) Local differences in mineral content in vertebral trabecular bone measured by dual-energy computed tomography. Acta Radiol 30(4):369-371
14. Hulme PA, Boyd SK, Ferguson SJ (2007) Regional variation in vertebral bone morphology and its contribution to vertebral fracture strength. Bone 41(6):946-957. doi: 10.1016/j.bone.2007.08.019
15. Mosekilde L (1998) The effect of modelling and remodelling on human vertebral body architecture. Technol Health Care 6(5-6):287-297
16. Simpson EK, Parkinson IH, Manthey B, Fazzalari NL (2001) Intervertebral disc disorganization is related to trabecular bone architecture in the lumbar spine. J Bone Miner Res 16(4):681-687
17. Oda K, Shibayama Y, Abe M, Onomura T (1998) Morphogenesis of vertebral deformities in involutional osteoporosis. Age-related, three-dimensional trabecular structure. Spine 23(9):1050-1055, discussion 1056
18. Nazarian A, Stauber M, Zurakowski D, Snyder BD, Muller R (2006) The interaction of microstructure and volume fraction in predicting failure in cancellous bone. Bone 39(6):1196-1202
19. Nazarian A, Meier D, Müller R, Snyder BD (2009) Functional dependence of cancellous bone shear properties on trabecular microstructure evaluated using time-lapsed micro-computed tomographic imaging and torsion testing. J Orthop Res 27(12):1667-1674
20. Yeh OC, Keaveny TM (1999) Biomechanical effects of intra-specimen variations in trabecular architecture: a three-dimensional finite element study. Bone 25:223-228
21. Jaasma MJ, Bayraktar HH, Niebur GL, Keaveny TM (2002) Biomechanical effects of intraspecimen variations in tissue modulus for trabecular bone. J Biomech 35(2):237-246
22. Kim D-G, Hunt C, Zauel R, Fyhrie D, Yeni Y (2007) The effect of regional variations of the trabecular bone properties on the compressive strength of human vertebral bodies. Ann Biomed Eng 35(11):1907-1913. doi: 10.1007/s10439-007-9363-1
23. Ridler T, Calvard S (1978) Picture thresholding using an iterative selection method. IEEE Trans Syst Man Cybern 8(8):630-632
24. Kopperdahl DL, Pearlman JL, Keaveny TM (2000) Biomechanical consequences of an isolated overload on the human vertebral body. J Orthop Res 18:685-690
25. Buckley JM, Parmeshwar R, Deviren V, Ames CP (2009) An improved metric for quantifying the stiffnesses of intact human vertebrae. Proc Inst Mech Eng H 223(5):537-543
26. Hildebrand T, Ruegsegger P (1997) Quantification of bone microarchitecture with the structure model index. Comput Methods Biomech Biomed Engin 1(1):15-23
27. Harrigan TP, Jasty M, Mann RW, Harris WH (1988) Limitations of the continuum assumption in cancellous bone. J Biomech 21(4):269-275
28. Hussein AI, Barbone PE, Morgan EF (2012) Digital volume correlation for study of the mechanics of whole bones. Procedia IUTAM: full field measurements and identication in solid mechanics (in press)
29. Sutton MA, Wolters WJ, Peters WH, Ranson WF, McNeill SR (1983) Determination of displacements using an improved digital correlation method. Image Vis Comput 1(3):133-139
30. Liu L, Morgan EF (2007) Accuracy and precision of digital volume correlation in quantifying displacements and strains in trabecular bone. J Biomech 40(15):3516-3520. doi: 10.1016/j.jbiomech.2007.04.019
31. Hong J, Cabe GD, Tedrow JR, Hipp JA, Snyder BD (2004) Failure of trabecular bone with simulated lytic defects can be predicted non-invasively by structural analysis. J Orthop Res 22(3):479-486. doi: 10.1016/j.orthres.2003.09. 006
32. Whealan KM, Kwak SD, Tedrow JR, Inoue K, Snyder BD (2000) Noninvasive imaging predicts failure load of the spine with simulated osteolytic defects. J Bone Joint Surg Am 82(9):1240-1251
33. Schaffler MB, Burr DB (1988) Stiffness of compact bone: effects of porosity and density. J Biomech 21(1):13-16
34. Carter DR, Spengler DM (1978) Mechanical properties and composition of cortical bone. Clin Orthop 135(135):192-217
35. Morgan EF, Keaveny TM (2001) Dependence of yield strain of human trabecular bone on anatomic site. J Biomech 34(5):569-577
36. Godfrey LG (1998) Tests of non-nested regression models some results on small sample behaviour and the bootstrap. J Econ 84(1):59-74
37. Kinney JH, Ladd AJ (1998) The relationship between three-dimensional connectivity and the elastic properties of trabecular bone. J Bone Miner Res 13(5):839-845
38. Ito M, Ikeda K, Nishiguchi M, Shindo H, Uetani M, Hosoi T, Orimo H (2005) Multi-detector row CT imaging of vertebral microstructure for evaluation of fracture risk. J Bone Miner Res 20(10):1828-1836
39. Buckley JM, Cheng L, Loo K, Slyfield C, Xu Z (2007) Quantitative computed tomography-based predictions of vertebral strength in anterior bending. Spine (Phila Pa 1976) 32(9):1019-1027. doi: 10.1097/01.brs.0000260979.98101.9c
40. Snyder BD, Cordio MA, Nazarian A, Kwak SD, Chang DJ, Entezari V, Zurakowski D, Parker LM (2009) Noninvasive prediction of fracture risk in patients with metastatic cancer to the spine. Clin Cancer Res 15(24):7676
41. Adams MA, McNally DS, Dolan P (1996) 'Stress' distributions inside intervertebral discs. The effects of age and degeneration. J Bone Joint Surg Br 78(6):965-972