Preparation of S14161 and its analogues and the discovery of 6-bromo-8-ethoxy-3-nitro-2H-chromene as a more potent antitumor agent in vitro

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 11, 2013, Pages 3314-3319

  Yin, Shu Qiang ^a   Shi, Min ^b   Kong, Ting Ting ^a   Zhang, Cheng Mei ^a   Han, Kunkun ^b   Cao, Biyin ^b   Zhang, Zubin ^b   Du, Xiaolin ^b   Tang, Long Qian ^a   Mao, Xinliang ^b   Liu, Zhao Peng ^a  

^a SHANDONG UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

Author keywords

3 kinase pathway (PI3K); 3 Nitro 2H chromene; Akt phosphorylation; Antiproliferative; Antitumor; Apoptosis; inhibitors; Oxa Michael Henry reaction; Phosphoinositide

Indexed keywords

6 BROMO 8 ETHOXY 3 NITRO 2H CHROMENE; ANTINEOPLASTIC AGENT; CASPASE 3; CHROMENE DERIVATIVE; PROTEIN KINASE B; S 14161; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; DNA REPAIR; DRUG DESIGN; DRUG STRUCTURE; HELA CELL; HIGH THROUGHPUT SCREENING; HINGE REGION; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; LUNG CANCER; OVARY CANCER; PROSTATE CANCER; PROTEIN PHOSPHORYLATION; UTERINE CERVIX CANCER;

ANTINEOPLASTIC AGENTS; BENZOPYRANS; BINDING SITES; CATALYSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MOLECULAR DOCKING SIMULATION; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PIPERAZINES; PROLINE; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84877582940     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.03.097     Document Type: Article

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