Downregulation of β1-adrenergic receptors in rat C6 glioblastoma cells by hyperforin and hyperoside from St John's wort

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 6, 2013, Pages 907-915

  Jakobs, Daniel ^a   Hage Hülsmann, Anne ^a   Prenner, Lars ^a   Kolb, Christiane ^b   Weiser, Dieter ^b   Häberlein, Hanns ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Steigerwald Arzneimittelwerk GmbH   (Germany)

Author keywords

1 adrenergic receptor; downregulation; hyperforin; hyperoside; St John's wort

Indexed keywords

AMENTOFLAVONE; BETA 1 ADRENERGIC RECEPTOR; BIAPIGENIN; CYCLIC AMP; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; HYPERFORIN; HYPERICUM PERFORATUM EXTRACT; HYPERIN; QUERCETIN; RUTOSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; FLUORESCENCE CORRELATION SPECTROSCOPY; GLIOBLASTOMA; HYPERICUM PERFORATUM; NONHUMAN; PROTEIN LOCALIZATION; RAT; SECOND MESSENGER;

ANIMALS; CELL LINE, TUMOR; CELL MEMBRANE; CYCLIC AMP; DOWN-REGULATION; GLIOBLASTOMA; HYPERICUM; PHLOROGLUCINOL; PLANT EXTRACTS; QUERCETIN; RATS; RECEPTORS, ADRENERGIC, BETA-1; TERPENES;

EID: 84877581284     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12050     Document Type: Article

References (38)

1. Taylor C, et al. Mechanisms of action of antidepressants: from neurotransmitter systems to signaling pathways. Cell Signal 2005; 17: 549-557.
2. Krishnan V, Nestler EJ,. The molecular neurobiology of depression. Nature 2008; 455: 894-902.
3. Richelson E,. Pharmacology of antidepressants. Mayo Clin Proc 2001; 76: 511-527.
4. Briley M,. Specific serotonin and noradrenaline reuptake inhibitors (SNRIs). A review of their pharmacology, clinical efficacy and tolerability. Human Psychopharmacol 1998; 13: 99-111.
5. Ackenheil M,. The mechanism of action of antidepressants revised. J Neural Transm 1990; 32 (Suppl.): 29-37.
6. Vetulani J, Sulser F,. Action of various antidepressant treatments reduces reactivity of noradrenergic cyclic AMP-generating system in limbic forebrain. Nature 1975; 257: 495-496.
7. Racagni G, Brunello N,. Transynaptic mechanisms in the action of antidepressant drugs. Trends Pharmacol Sci 1984; 5: 527-531.
8. Müller WE, et al. Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract. Pharmacopsychiatry 1998; 31 (Suppl. 1): 16-21.
9. Singer A, et al. Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1. J Pharmacol Exp Ther 1999; 290: 1363-1368.
10. Butterweck V, et al. Flavonoids from Hypericum perforatum show antidepressant activity in the forced swimming test. Planta Med 2000; 66: 3-6.
11. Butterweck V, et al. Flavonoids of St. John's Wort reduce HPA axis function in the rat. Planta Med 2004; 70: 1008-1011.
12. 2- adrenergic receptor binding by hyperforin and hyperoside on rat C6 gliobastoma cells measured by fluorescence correlation spectroscopy. Biochemistry 2007; 46: 5106-5113.
13. Karioti A, Bilia AR,. Hypericins as potential leads for new therapeutics. Int J Mol Sci 2010; 11: 562-594.
14. 2-adrenergic receptors in rat cerebral cortex are independently regulated. Science 1979; 204: 866-868.
15. Matrisciano F, et al. Metabolic glutamate receptors and neuroadaptation to antidepressants: imipramine-induced down-regulation of β-adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands. J Neurochem 2005; 93: 1345-1352.
16. Bürgi S, et al. Antidepressant-induced switch of beta 1-adrenoceptor trafficking as a mechanism for drug action. J Biol Chem 2003; 278: 1044-1052.
17. Chen J, Rasenick MM,. Chronic treatment of C6 glioma cells with antidepressant drugs increases functional coupling between a G protein (Gs) and adenylyl cyclase. J Neurochem 1995; 64: 724-732.
18. Manji HK, et al. Down-regulation of beta receptors by desipramine in vitro involves PKC/phospholipase A2. Psychopharmacol Bull 1991; 27: 247-253.
19. Marquardt DW,. An algorithm for least-squares estimation of nonlinear parameters. J Soc Ind Appl Math 1963; 11: 431-441.
20. Gillman PK,. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol 2007; 151: 737-748.
21. Nair NPV, et al. Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: focus on Moclobemide. J Psychiatr Neurosci 1993; 18: 214-225.
22. Blier P,. Crosstalk between the norepinephrine and serotonin systems and its role in the antidepressant response. J Psychiatry Neurosci 2001; 26 (Suppl.): S3-10.
23. Dremencov E, et al. Brain norepinephrine system as a target for antidepressant and mood stabilizing medications. Curr Drug Targets 2009; 10: 1061-1068.
24. Millan MJ,. Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 2006; 110: 135-370.
25. Schreiber G, Avissar S,. Regulators of G-protein-coupled receptor-G-protein coupling: antidepressants mechanism of action. Expert Rev Neurother 2007; 7: 75-84.
26. Frazer A, Benmansour S,. Delayed pharmacological effects of antidepressants. Mol Psychiatry 2002; 7 (Suppl. 1): S23-S28.
27. Gastpar M, et al. Comparative efficacy and safety of a once-daily dosage of hypericum extract STW3-VI and citalopram in patients with moderate depression: a double-blind, randomised, multicentre, placebo-controlled study. Pharmacopsychiatry 2006; 39: 66-75.
28. Linde K, et al. St John's wort for major depression. Cochrane Database Syst Rev 2008; (4): CD000448.
29. DGPPN, BÄK, KBV, AWMF, AkdÄ, BPtK, BApK, DAGSHG, DEGAM, DGPM, DGPs, DGRW eds. für die Leitliniengruppe Unipolare Depression: S3-Leitlinie/Nationale VersorgungsLeitlinie Unipolare Depression. 1. Auflage 2009. Berlin, Düsseldorf: DGPPN, ÄZQ, AWMF, 2009. Internet: http://www.versorgungsleitlinien.de/themen/depression
30. Fishman PH, et al. Independent and coordinate regulation of beta 1- and beta 2-adrenergic receptors in rat C6 glioma cells. J Recept Res 1994; 14: 281-296.
31. Kientsch U, et al. St. John's wort extract Ze 117 (Hypericum perforatum) inhibits norepinephrine and serotonin uptake into rat brain slices and reduces 3-adrenoceptor numbers on cultured rat brain cells. Pharmacopsychiatry 2001; 34 (Suppl. 1): 56-60.
32. Golan M, et al. Antidepressants increase β-arrestin2 ubiquitinylation and degradation by the proteasomal pathway in C6 rat glioma cells. J Pharmacol Exp Ther 2010; 332: 970-976.
33. Briddon SJ, Hill SJ,. Pharmacology under the microscope: the use of fluorescence correlation spectroscopy to determine the properties of ligand-receptor complexes. Trends Pharmacol Sci 2007; 28: 637-645.
34. Chini B, Parenti M,. G-protein coupled receptors in lipid rafts and caveolae: how, when and why do they go there? J Mol Endocrinol 2004; 32: 325-338.
35. Ostrom RS, Insel PA,. The evolving role of lipid rafts and caveolae in G-protein-coupled receptor signaling: implications for molecular pharmacology. Br J Pharmacol 2004; 143: 235-245.
36. Rapacciuolo A, et al. Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates β-1 adrenergic receptor endocytosis through different pathways. J Biol Chem 2003; 278: 35403-35411.
37. Meissner O, Häberlein H,. Lateral mobility and specific binding to GABA(A) receptors on hippocampal neurons monitored by fluorescence correlation spectroscopy. Biochemistry 2003; 42: 1667-1672.
38. Hegener O, et al. Benzodiazepine binding studies on living cells: application of small ligands for fluorescence correlation spectroscopy. Biol Chem 2002; 383: 1801-1807.