Interaction between Obesity and the NFKB1 - 94ins/delATTG Promoter Polymorphism in Relation to Incident Acute Coronary Syndrome: A Follow Up Study in Three Independent Cohorts

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Stegger, Jakob Gerhard ^a   Schmidt, Erik Berg ^a   Berentzen, Tina Landsvig ^b   Tjønneland, Anne ^c   Vogel, Ulla ^d   Rimm, Eric ^e,f   Sørensen, Thorkild I A ^b,g   Overvad, Kim ^a,h   Jensen, Majken K ^a,e  

^a AALBORG UNIVERSITY HOSPITAL   (Denmark)

^b Centre for Health and Society   (Denmark)

^c INSTITUTE OF CANCER EPIDEMIOLOGY   (Denmark)

^d NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

^g University of Copenhagen   (Denmark)

^h AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ABDOMINAL OBESITY; ACUTE CORONARY SYNDROME; ADULT; ALLELE; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENETIC POLYMORPHISM; GENOTYPE; GLUTEOFEMORAL OBESITY; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PROMOTER REGION; RISK ASSESSMENT;

ACUTE CORONARY SYNDROME; ADULT; AGED; BASE SEQUENCE; FEMALE; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; MUTAGENESIS, INSERTIONAL; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; OBESITY; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; SEQUENCE DELETION;

EID: 84877334358     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063004     Document Type: Article

References (31)

1. Bogers RP, Bemelmans WJ, Hoogenveen RT, Boshuizen HC, Woodward M, et al. (2007) Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels: A meta-analysis of 21 cohort studies including more than 300 000 persons. Arch Intern Med 167: 1720-1728.
2. Canoy D, (2008) Distribution of body fat and risk of coronary heart disease in men and women. Curr Opin Cardiol 23: 591-598.
3. Stegger JG, Schmidt EB, Obel T, Berentzen TL, Tjonneland A, et al. (2011) Body composition and body fat distribution in relation to later risk of acute myocardial infarction: A danish follow-up study. Int J Obes (Lond) 35: 1433-1441.
4. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, et al. (2004) Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study. Lancet 364: 937-952.
5. Kershaw EE, Flier JS, (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89: 2548-2556.
6. Hajer GR, van Haeften TW, Visseren FL, (2008) Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29: 2959-2971.
7. Ridker PM, Morrow DA, (2003) C-reactive protein, inflammation, and coronary risk. Cardiol Clin 21: 315-325.
8. Ross R, (1999) Atherosclerosis-an inflammatory disease. N Engl J Med 340: 115-126.
9. de Winther MP, Kanters E, Kraal G, Hofker MH, (2005) Nuclear factor kappaB signaling in atherogenesis. Arterioscler Thromb Vasc Biol 25: 904-914.
10. Pereira SG, Oakley F, (2008) Nuclear factor-kappaB1: Regulation and function. Int J Biochem Cell Biol 40: 1425-1430.
11. Cao S, Zhang X, Edwards JP, Mosser DM, (2006) NF-kappaB1 (p50) homodimers differentially regulate pro- and anti-inflammatory cytokines in macrophages. J Biol Chem 281: 26041-26050.
12. Karban AS, Okazaki T, Panhuysen CI, Gallegos T, Potter JJ, et al. (2004) Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet 13: 35-45.
13. Van der Heiden K, Cuhlmann S, Luong le A, Zakkar M, Evans PC, (2010) Role of nuclear factor kappaB in cardiovascular health and disease. Clin Sci (Lond) 118: 593-605.
14. Vogel U, Jensen MK, Due KM, Rimm EB, Wallin H, et al. (2011) The NFKB1 ATTG ins/del polymorphism and risk of coronary heart disease in three independent populations. Atherosclerosis 219: 200-204.
15. Liou YJ, Wang HH, Lee MT, Wang SC, Chiang HL, et al. (2012) Genome-wide association study of treatment refractory schizophrenia in han chinese. PLoS One 7: e33598.
16. Rimm EB, Stampfer MJ, Colditz GA, Chute CG, Litin LB, et al. (1990) Validity of self-reported waist and hip circumferences in men and women. Epidemiology 1: 466-473.
17. Tjonneland A, Olsen A, Boll K, Stripp C, Christensen J, et al. (2007) Study design, exposure variables, and socioeconomic determinants of participation in diet, cancer and health: A population-based prospective cohort study of 57,053 men and women in denmark. Scand J Public Health 35: 432-441.
18. Rimm EB, Giovannucci EL, Stampfer MJ, Colditz GA, Litin LB, et al. (1992) Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol 135: 1114-26; discussion 1127-36.
19. Colditz GA, Manson JE, Hankinson SE, (1997) The nurses' health study: 20-year contribution to the understanding of health among women. J Womens Health 6: 49-62.
20. Vogel U, Segel S, Dethlefsen C, Tjonneland A, Saber AT, et al. (2010) Associations between COX-2 polymorphisms, blood cholesterol and risk of acute coronary syndrome. Atherosclerosis 209: 155-162.
21. Vogel U, Segel S, Dethlefsen C, Tjonneland A, Saber AT, et al. (2009) PPARgamma Pro12Ala polymorphism and risk of acute coronary syndrome in a prospective study of danes. BMC Med Genet 10: 52.
22. Miller SA, Dykes DD, Polesky HF, (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16: 1215.
23. Andersen TF, Madsen M, Jorgensen J, Mellemkjoer L, Olsen JH, (1999) The danish national hospital register. A valuable source of data for modern health sciences. Dan Med Bull 46: 263-268.
24. Joensen AM, Jensen MK, Overvad K, Dethlefsen C, Schmidt E, et al. (2009) Predictive values of acute coronary syndrome discharge diagnoses differed in the danish national patient registry. J Clin Epidemiol 62: 188-194.
25. Jensen MK, Rimm EB, Mukamal KJ, Edmondson AC, Rader DJ, et al. (2009) The T111I variant in the endothelial lipase gene and risk of coronary heart disease in three independent populations. Eur Heart J 30: 1584-1589.
26. Rimm EB, Giovannucci EL, Willett WC, Colditz GA, Ascherio A, et al. (1991) Prospective study of alcohol consumption and risk of coronary disease in men. Lancet 338: 464-468.
27. Jensen MK, Mukamal KJ, Overvad K, Rimm EB, (2008) Alcohol consumption, TaqIB polymorphism of cholesteryl ester transfer protein, high-density lipoprotein cholesterol, and risk of coronary heart disease in men and women. Eur Heart J 29: 104-112.
28. Korn EL, Graubard BI, Midthune D, (1997) Time-to-event analysis of longitudinal follow-up of a survey: Choice of the time-scale. Am J Epidemiol 145: 72-80.
29. Kalbfleisch JD, Lawless JF, (1988) Likelihood analysis of multi-state models for disease incidence and mortality. Stat Med 7: 149-160.
30. Rothman KJGS (1998) Modern epidemiology. Philadelphia: Lippincott Williams and Wilkins.
31. Hosmer DW, Lemeshow S, (1992) Confidence interval estimation of interaction. Epidemiology 3: 452-456.